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肺癌

肺癌是最常见的肺原发性恶性肿瘤,目前全世界每年发病人数第二、死亡人数第二。据世界卫生组织国际癌症研究署(IARC)发布的2020年全球癌症负担数据,2020年全世界新增肺癌病例220万(仅次于乳腺癌),新增肺癌死亡病例180万(远超其他癌症)。非小细胞肺癌(NSCLC)约占所有肺癌病例的85%,其5年生存率仅为20%左右。

近年来,肺癌药物研发进展迅猛,目前全球已上市生物药数量达102种,聚焦于EGFR、ALK等靶点的靶向药物和PD-1/PD-L1免疫疗法、抗体偶联药物(ADC)。

  • 在靶向治疗方面,针对EGFR、ALK、ROS1等特定基因突变的药物不断涌现。例如,针对EGFR突变的非小细胞肺癌,已经开发出多种代的TKI(酪氨酸激酶抑制剂),如第一代的吉非替尼、第二代的阿法替尼以及第三代的奥希替尼等。此外,针对EGFR外显子20插入突变的NSCLC患者,amivantamab联合化疗已经显示出显著的疗效。
  • 免疫治疗方面,PD-1/PD-L1抑制剂如帕博利珠单抗(pembrolizumab)、纳武单抗(nivolumab)等已经在肺癌治疗中取得显著进展。例如,PAPILLON研究显示,amivantamab联合化疗可显著延长携带EGFR外显子20插入突变晚期NSCLC的中位PFS6。此外,针对PD-L1表达水平较高的非小细胞肺癌患者,免疫治疗已经成为新的标准治疗选项。
  • 抗体药物偶联物(ADC)是近年来肺癌治疗领域的新兴研究方向。ADC药物通过将抗体与化疗药物或放射性物质结合,提高治疗的靶向性和效果。例如,针对HER2突变的非小细胞肺癌,新型ADC药物如trastuzumab deruxtecan(T-DXd)已经显示出较好的疗效。

肺癌药物靶点相关产品推荐

● 靶点蛋白

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP007479HU Activity Verified

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP006163HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml

CSB-MP007763HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

CSB-MP013714HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized MET at 2 μg/ml can bind Anti-MET recombinant antibody, the EC50 is 2.379-3.094.

CSB-MP675446HU Activity Verified

FACS assay shows that Human TIGIT can bind to 293F cell overexpressing human CD155.

CSB-MP023997HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized TNFSF9 at 2 μg/ml can bind TNFRSF9(CSB-MP023984HU1), the EC50 is 2.671-3.702 ng/mL.

产品名称 货号 靶点 来源 蛋白标签
Recombinant Human Basigin (BSG), partial (Active) CSB-MP002831HU1 BSG Mammalian cell C-terminal hFc-tagged
Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial (Active) CSB-MP773799HU BTLA Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial (Active) CSB-MP773799HU1 BTLA Mammalian cell C-terminal 10xHis-tagged
Recombinant Human C-C chemokine receptor type 8 (CCR8)-VLPs (Active) CSB-MP004847HU CCR8 Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active) CSB-MP733578HU CD276 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD44 antigen (CD44), partial (Active) CSB-MP004938HU(F1) CD44 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD44 antigen (CD44), partial, Biotinylated (Active) CSB-MP004938HU(F1)j1-B CD44 Mammalian cell C-terminal mFc-Avi-tagged
Recombinant Macaca fascicularis CD44 antigen (CD44), partial (Active) CSB-MP4290MOV CD44 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) CSB-MP005165HU CEACAM5 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) (Active) CSB-MP005166HU CEACAM6 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Claudin-6 (CLDN6)-VLPs (Active) CSB-MP005508HU(A4) CLDN6 Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Claudin-6 (CLDN6)-VLPs, Fluorescent (Active) CSB-MP005508HU(A4)f4 CLDN6 Mammalian cell C-terminal GFP-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged
Recombinant Human Delta-like protein 3 (DLL3), partial (Active) CSB-MP882142HU DLL3 Mammalian cell C-terminal 6xHis-tagged
Recombinant Macaca fascicularis Delta-like protein 3 (DLL3), partial (Active) CSB-MP3536MOV DLL3 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) CSB-MP007479HU EGFR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) CSB-MP007763HU ERBB2 Mammalian cell C-terminal 6xHis-tagged

● 细胞株

● 抗体

CD274 Recombinant Monoclonal Antibody
CSB-RA292372A0HU
CSB-RA292372A0HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU
CSB-RA006163MA1HU FC

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU FC

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

MET Recombinant Monoclonal Antibody
CSB-RA983271A0HU
CSB-RA983271A0HU FC

Overlay histogram showing Hela cells stained with CSB-RA983271A0HU (red line) at 1:50.

产品名称 货号 靶点 反应种属 应用范围
ALB Recombinant Monoclonal Antibody CSB-RA264109A0HU ALB Human ELISA, FC
BTLA Recombinant Monoclonal Antibody CSB-RA773799MA1HU BTLA Human ELISA, FC
CA9 Recombinant Monoclonal Antibody CSB-RA614990A0HU CA9 Human ELISA, IHC
CCR8 Recombinant Monoclonal Antibody CSB-RA004847A1HU CCR8 Human FC
CCR8 Recombinant Monoclonal Antibody CSB-RA004847MA3HU CCR8 Human FC
CCR8 Recombinant Monoclonal Antibody CSB-RA004847MA2HU CCR8 Human FC
CCR8 Recombinant Monoclonal Antibody CSB-RA004847MA4HU CCR8 Human FC
CD27 Recombinant Monoclonal Antibody CSB-RA953976A0HU CD27 Human ELISA, WB
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD3E Recombinant Monoclonal Antibody CSB-RA004931MA1HU CD3E Human ELISA, FC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD44 Recombinant Monoclonal Antibody CSB-RA004938A0HU CD44 Human ELISA, WB, IHC
CD44 Recombinant Monoclonal Antibody CSB-RA292372A0HU CD44 Human ELISA, WB, IHC, IF, FC
CD44 Recombinant Monoclonal Antibody CSB-RA004938MA1HU CD44 Human ELISA, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
CD86 Recombinant Monoclonal Antibody CSB-RA004965A0HU CD86 Human ELISA, WB
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA3HU CEACAM5 Human ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA1HU CEACAM5 Human ELISA
CHEK1 Recombinant Monoclonal Antibody CSB-RA176809A0HU CHEK1 Human ELISA, WB, IHC, IF

● ELISA试剂盒

产品名称 货号 靶点 检测范围 灵敏度
牛白蛋白(ALB)酶联免疫试剂盒 CSB-E08664b ALB 0.313 μg/mL-80 μg/mL 0.148 μg/mL
小鼠白蛋白酶联免疫试剂盒 CSB-E13878m ALB 0.781 μg/mL-200 μg/mL 0.110 μg/mL
犬白蛋白(Alb)酶联免疫试剂盒 CSB-E15757c ALB 0.273 μg/mL-35 μg/mL 0.266 μg/mL
绵羊白蛋白酶联免疫试剂盒 CSB-E15839Sh ALB 350 μg/mL-21.88 μg/mL 5.5 μg/mL
马白蛋白酶联免疫试剂盒 CSB-E16205Hs ALB 1.25 μg/mL-80 μg/mL 1.247 μg/mL
猪白蛋白酶联免疫试剂盒 CSB-E16207p ALB 0.03 μg/mL-7000 μg/mL 0.03 μg/mL
山羊白蛋白(Alb)酶联免疫试剂盒 CSB-E15758G ALB 0.17 μg/mL-350 μg/mL 0.17 μg/mL
豚鼠白蛋白(ALB)酶联免疫试剂盒 CSB-E15765Gp ALB 0.156 μg/mL-10 μg/mL 0.09 μg/mL
兔白蛋白酶联免疫试剂盒 CSB-E16204Rb ALB 0.273 μg/mL-70 μg/mL 0.117 μg/mL
人酪氨酸蛋白激酶受体UFO(AXL)酶联免疫试剂盒 CSB-EL002476HU AXL 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
小鼠酪氨酸蛋白激酶受体UFO(AXL)酶联免疫试剂盒 CSB-EL002476MO AXL 31.25 pg/ml-2000 pg/ml 7.81 pg/ml
人CD147分子(CD147)酶联免疫试剂盒 CSB-E12994h BSG 12.5 pg/mL-800 pg/mL 3.12 pg/mL
人B和T淋巴细胞衰减因子(BTLA)酶联免疫试剂盒 CSB-EL002868HU BTLA 0.45 ng/mL-30 ng/mL 0.11 ng/mL
小鼠B和T淋巴细胞衰减因子(BTLA)酶联免疫试剂盒 CSB-EL002868MO BTLA 0.625 ng/mL-40 ng/mL 0.156 ng/mL
人碳酸酐酶9(CA9)酶联免疫试剂盒 CSB-E13266h CA9 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
人程序性死亡因子配体1(PD-L1/CD274)酶联免疫试剂盒 CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
小鼠程序性细胞死亡配体1(CD274) ELISA Kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
人可溶性CD276分子(sCD276/sB7-H3)酶联免疫试剂盒 CSB-E14285h CD276 3.12 ng/mL-200 ng/mL 0.78 ng/mL
人可溶性CD28(sCD28)酶联免疫试剂盒 CSB-E09296h CD28 0.625 ng/mL-40 ng/mL 0.156 ng/mL
小鼠肿瘤坏死因子受体超家族成员5(CD40)酶联免疫试剂盒 CSB-EL004936MO CD40 Request Information Request Information