CD3E
CD3E，即T细胞受体复合物的CD3ε亚基，它是一种在T细胞表面表达的糖蛋白，由CD3E基因编码。CD3E是T细胞受体（TCR）信号传导复合物的一部分，与TCRαβ或TCRγδ亚单位非共价结合。其作用机制是在T细胞受体识别并结合到主要组织相容性复合物（MHC）呈递的抗原肽时，CD3E与其他CD3分子协同，传递激活信号，导致T细胞的激活。信号通路涉及酪氨酸激酶的激活，如ζ链相关蛋白激酶76（ZAP-70），进而激活下游的多种信号分子，包括磷脂酰肌醇3激酶（PI3K）、蛋白激酶C（PKC）和丝裂原激活蛋白激酶（MAPK）。这些信号通路最终导致T细胞增殖、分化和效应功能的发展。在生物学意义上，CD3E对T细胞介导的免疫应答至关重要，它参与调节细胞毒性T细胞和辅助T细胞的激活，对清除病原体、抗肿瘤免疫以及自身免疫反应的调控具有重要作用。CD3E的功能异常可能与某些免疫缺陷和自身免疫疾病相关。
热销产品
Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial (CSB-MP004931HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CD3E Recombinant Monoclonal Antibody (CSB-RA004931MA1HU)
验证数据
Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*106cells) used under the same conditions. Acquisition of >10, 006 events was performed.
CD3E Antibodies
CD3E for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA10484A0Rb | CD3E Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA10484C0Rb | CD3E Antibody, FITC conjugated | Human | |
| CSB-PA004931GA01HU | CD3E Antibody | Human | ELISA,WB,IHC |
| CSB-PA949010 | CD3E Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA005833 | CD3E Antibody | Human | WB, ELISA |
| CSB-PA070244 | CD3E Antibody | Human | WB, IHC, ELISA |
| CSB-PA004931HA01HU | CD3E Antibody | Human | ELISA, IHC, IF |
| CSB-PA004931HB01HU | CD3E Antibody, HRP conjugated | Human | ELISA |
| CSB-PA004931HC01HU | CD3E Antibody, FITC conjugated | Human | |
| CSB-PA004931HD01HU | CD3E Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA004931MA1HU | CD3E Recombinant Monoclonal Antibody | Human | ELISA, FC |
CD3E Proteins
CD3E Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004931MO | Recombinant Mouse T-cell surface glycoprotein CD3 epsilon chain (Cd3e), partial | Yeast |
| CSB-BP004931MO CSB-MP004931MO CSB-EP004931MO-B |
Recombinant Mpuse T-cell surface glycoprotein CD3 epsilon chain (Cd3e), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP004931MO | Recombinant Mouse T-cell surface glycoprotein CD3 epsilon chain (Cd3e), partial | E.coli |
CD3E Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004931DO1 CSB-EP004931DO1 CSB-BP004931DO1 CSB-MP004931DO1 CSB-EP004931DO1-B |
Recombinant Dog T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004931DO | Recombinant Dog T-cell surface glycoprotein CD3 epsilon chain (CD3E) | in vitro E.coli expression system |
CD3E Proteins for Ovis aries (Sheep)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004931SH1 CSB-EP004931SH1 CSB-BP004931SH1 CSB-MP004931SH1 CSB-EP004931SH1-B |
Recombinant Sheep T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004931SH | Recombinant Sheep T-cell surface glycoprotein CD3 epsilon chain (CD3E) | in vitro E.coli expression system |
CD3E Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004931HU | Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast |
| CSB-EP004931HU(A4) | Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E) | E.coli |
| CSB-CF004931HU | Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E) | in vitro E.coli expression system |
| CSB-EP004931HU | Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | E.coli |
| CSB-BP004931HU CSB-EP004931HU-B |
Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP004931HU | Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Mammalian cell |
| CSB-MP004931HU | Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Mammalian cell |
CD3E Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP637748BO CSB-EP637748BO CSB-BP637748BO CSB-MP637748BO CSB-EP637748BO-B |
Recombinant Bovine T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3E Proteins for Felis catus (Cat) (Felis silvestris catus)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP725239CA CSB-EP725239CA CSB-BP725239CA CSB-MP725239CA CSB-EP725239CA-B |
Recombinant Cat T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3E Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP801781PI CSB-BP801781PI CSB-MP801781PI CSB-EP801781PI-B |
Recombinant Pig T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3E Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP822100MOV CSB-EP822100MOV CSB-BP822100MOV CSB-MP822100MOV CSB-EP822100MOV-B |
Recombinant Macaca fascicularis T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3E Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP822537CH CSB-EP822537CH CSB-BP822537CH CSB-MP822537CH CSB-EP822537CH-B |
Recombinant Chicken T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3E Proteins for Oryctolagus cuniculus (Rabbit)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP890601RB CSB-EP890601RB CSB-BP890601RB CSB-MP890601RB CSB-EP890601RB-B |
Recombinant Rabbit T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
