CXCR4
CXCR4：G蛋白耦联受体（GPCR）家族，再出肿瘤免疫治疗新药！
趋化因子受体（C X C chemokine receptor 4，CXCR4）是一个具有7次跨膜结构的G蛋白耦联受体。CXCR4作为GPCR家族中的一员，GPCR的超家族群已经被证明是许多药物的药理作用靶点。CXCR4在体内大部分组织和器官上都有表达，包括骨髓、脐血和动员的外周血来源的细胞表面，以及多种非造血干细胞表面表达。近年来研究发现，肿瘤细胞转移到特定器官是不同器官通过趋化作用吸引特定类型肿瘤细胞归巢的结果。在众多的趋化因子受体中，CXCR4在许多肿瘤中都存在表达增强。目前的研究表明，与趋化因子受体CXCR4相关的癌症超过23种，它还能促进血管生成，细胞的转移、生长或生存。此外，还参与HIV病毒感染。这些生物学功能决定了CXCR4靶向药可用于肿瘤、造血干细胞动员、HIV等疾病的治疗。
CUSABIO-哺乳包膜VLPs平台成功开发CXCR4全长膜蛋白（7次跨膜），展示了完整生物活性。
热销产品
Recombinant Human C-X-C chemokine receptor type 4(CXCR4)-VLPs (Active)（CSB-MP006254HU(F1)）
High Specificity Validated by Western Blot (WB)
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CSB-MP006254HU(F1) is detected by Mouse anti-6*His monoclonal antibody.
Excellent Bioactivity Validated by Functional ELISA
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Immobilized Human CXCR4 at 10 μg/ml can bind Anti-CXCR4 recombinant antibody (CSB-RA006254MA01HU), the EC50 is 101.7-253.6 ng/mL.
CXCR4 Antibodies
CXCR4 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA006254GA01HU | CXCR4 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA002588 | CXCR4 Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA060127 | Phospho-CXCR4 (S339) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IF, ELISA |
| CSB-PA006254YA01HU | CXCR4 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA006254YB01HU | CXCR4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA006254YC01HU | CXCR4 Antibody, FITC conjugated | Human | |
| CSB-PA006254YD01HU | CXCR4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA263860 | CXCR4 Antibody | Human | ELISA,IHC |
| CSB-PA996565 | CXCR4 Antibody | Human | ELISA,IHC |
| CSB-PA250029 | CXCR4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA099227 | CXCR4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA569311A0HU | CXCR4 Recombinant Monoclonal Antibody | Human | ELISA, IF |
| CSB-RA006254MA01HU | CXCR4 Recombinant Monoclonal Antibody | Human | ELISA |
CXCR4 Proteins
CXCR4 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006254MO1 CSB-EP006254MO1 CSB-BP006254MO1 CSB-MP006254MO1 CSB-EP006254MO1-B |
Recombinant Mouse C-X-C chemokine receptor type 4 (Cxcr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254MO | Recombinant Mouse C-X-C chemokine receptor type 4 (Cxcr4) | in vitro E.coli expression system |
CXCR4 Proteins for Macaca mulatta (Rhesus macaque)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006254MOW1 CSB-EP006254MOW1 CSB-BP006254MOW1 CSB-MP006254MOW1 CSB-EP006254MOW1-B |
Recombinant Macaca mulatta (Rhesus macaque) C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254MOW | Recombinant Macaca mulatta (Rhesus macaque) C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006254BO1 CSB-EP006254BO1 CSB-BP006254BO1 CSB-MP006254BO1 CSB-EP006254BO1-B |
Recombinant Bovine C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254BO | Recombinant Bovine C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006254CA1 CSB-EP006254CA1 CSB-BP006254CA1 CSB-MP006254CA1 CSB-EP006254CA1-B |
Recombinant Cat C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254CA | Recombinant Cat C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006254RA1 CSB-EP006254RA1 CSB-BP006254RA1 CSB-MP006254RA1 CSB-EP006254RA1-B |
Recombinant Rat C-X-C chemokine receptor type 4 (Cxcr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254RA | Recombinant Rat C-X-C chemokine receptor type 4 (Cxcr4) | in vitro E.coli expression system |
CXCR4 Proteins for Papio anubis (Olive baboon)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006254ERI1 CSB-EP006254ERI1 CSB-BP006254ERI1 CSB-MP006254ERI1 CSB-EP006254ERI1-B |
Recombinant Papio anubis C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254ERI | Recombinant Papio anubis C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Pan troglodytes (Chimpanzee)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006254EQV1 CSB-EP006254EQV1 CSB-BP006254EQV1 CSB-MP006254EQV1 CSB-EP006254EQV1-B |
Recombinant Pan troglodytes C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254EQV | Recombinant Pan troglodytes C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006254DRI1 CSB-EP006254DRI1 CSB-BP006254DRI1 CSB-MP006254DRI1 CSB-EP006254DRI1-B |
Recombinant Cercocebus atys C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254DRI | Recombinant Cercocebus atys C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP630683MOV1 CSB-EP630683MOV1 CSB-BP630683MOV1 CSB-MP630683MOV1 CSB-EP630683MOV1-B |
Recombinant Macaca fascicularis C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF630683MOV | Recombinant Macaca fascicularis C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Ovis aries (Sheep)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP638935SH1 CSB-EP638935SH1 CSB-BP638935SH1 CSB-MP638935SH1 CSB-EP638935SH1-B |
Recombinant Sheep C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF638935SH | Recombinant Sheep C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP668610DO1 CSB-EP668610DO1 CSB-BP668610DO1 CSB-MP668610DO1 CSB-EP668610DO1-B |
Recombinant Dog C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF668610DO | Recombinant Dog C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP755226PI1 CSB-EP755226PI1 CSB-BP755226PI1 CSB-MP755226PI1 CSB-EP755226PI1-B |
Recombinant Pig C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF755226PI | Recombinant Pig C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Tupaia chinensis (Chinese tree shrew)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP768744TDAE1 CSB-EP768744TDAE1 CSB-BP768744TDAE1 CSB-MP768744TDAE1 CSB-EP768744TDAE1-B |
Recombinant Tupaia chinensis C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF768744TDAE | Recombinant Tupaia chinensis C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Saimiri sciureus (Common squirrel monkey)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP810237SWD1 CSB-EP810237SWD1 CSB-BP810237SWD1 CSB-MP810237SWD1 CSB-EP810237SWD1-B |
Recombinant Saimiri sciureus C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF810237SWD | Recombinant Saimiri sciureus C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Callithrix jacchus (White-tufted-ear marmoset)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP818191CYL1 CSB-EP818191CYL1 CSB-BP818191CYL1 CSB-MP818191CYL1 CSB-EP818191CYL1-B |
Recombinant Callithrix jacchus C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF818191CYL | Recombinant Callithrix jacchus C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP886927DSU1 CSB-EP886927DSU1 CSB-BP886927DSU1 CSB-MP886927DSU1 CSB-EP886927DSU1-B |
Recombinant Chlorocebus aethiops C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF886927DSU | Recombinant Chlorocebus aethiops C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-CF006254HU | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
| CSB-EP006254HU1 | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4), partial | E.coli |
| CSB-EP006254HU1e0 | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4), partial | E.coli |
| CSB-MP006254HU | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4)-VLPs | Mammalian cell |
| CSB-MP006254HU(F1) | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4)-VLPs (Active) | Mammalian cell |
CXCR4 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-CF006254HUa0 | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 ELISA Kit
CXCR4 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E12825h | Human CXC-chemokine receptor 4(CXCR4)ELISA Kit | serum, plasma, tissue homogenates | 0.39 pg/mL |
CXCR4 ELISA Kit for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E12703r | Rat CXC-chemokine receptor 4(CXCR4)ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.039 ng/mL |
