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  4. Recombinant Rat C-X-C chemokine receptor type 4 (Cxcr4)

Recombinant Rat C-X-C chemokine receptor type 4 (Cxcr4)

  • 货号：
    CSB-CF006254RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Cxcr4; Cmkar4; C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; Fusin; Leukocyte-derived seven transmembrane domain receptor; LESTR; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD antigen CD184
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-349
  • 氨基酸序列
    MEIYTSDNYSEEVGSGDYDSNKEPCFRDENENFNRIFLPTIYFIIFLTGIVGNGLVILVM GYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAMADWYFGKFLCKAVHIIYTVNLYSS VLILAFISLDRYLAIVHATNSQSARKLLAEKAVYVGVWIPALLLTIPDIIFADVSQGDGR YICDRLYPDSLWMVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVI LILAFFACWLPYYVGISIDSFILLEVIKQGCEFESVVHKWISITEALAFFHCCLNPILYA FLGAKFKSSAQHALNSMSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.
  • 基因功能参考文献：
    1. suggest that ubiquitin (UB) interacts with CXCR4, and UB/CXCR4 interaction affects intracellular signaling, and modulates fibroblast phenotype and function PMID: 30195032
    2. Study demonstrated that the elevated expression of CXCR4 and relative serum levels in renal tubular epithelial cells were correlated with the severity of renal ischemia reperfusion injury. PMID: 29073721
    3. These results suggest that modification of Bone marrow-derived mesenchymal stem cells by dual expression of CXCR4 and IL-35 may provide an effective therapeutic strategy for inflammatory bowel disease. PMID: 29524405
    4. Suppression of miR-210 attenuated hypoxia-induced cell injury in H9c2 cells by targeting CXCR4, along with activations of the SMAD and mTOR signaling pathways. PMID: 29710553
    5. The aim of the present study was to assess whether fibrosis markers, estrogen receptor (ER)alpha and the stromal derived factor (SDF)1/CXC chemokine receptor type 4 (CXCR4) axis are abnormally expressed in Intrauterine adhesions endometrium. PMID: 29568895
    6. Both bone marrow-derived endothelial progenitor cells and gastric endothelial cells express SDF-1 and CXCR4, which indicates direct paracrine interactions between these cells during neovascularization. PMID: 29550796
    7. the lower expression levels of CXCR4 and p-AKT may be responsible for the impaired osteogenic ability and lower chemotactic activity towards SDF-1alpha of OVX-bone marrow mesenchymal stem cells . PMID: 29207050
    8. The SDF-1alpha/CXCR4 axis drives proliferation and hypertrophy of and collagen production by CFs, PGVSMCs, and GMCs, particularly in cells from genetically hypertensive animals and when DPP4 is inhibited. PMID: 29114002
    9. CXC chemokine receptor type 4 antagonism alleviated renal interstitial fibrosis in long-term surviving kidney allografts by down-regulating expression of transforming growth factor beta1. PMID: 28585910
    10. Gene expression and localization of SDF-1 and CXCR4 was altered during fracture healing, which may contribute to the impaired fracture healing in DM. PMID: 28412763
    11. Data show that miR-338 exerts significant influence in the inhibition of morphine tolerance by suppressing CXCR4 in bone cancer pain (BCP). PMID: 28108674
    12. Study provided behavioral and morphological evidence that enriched environment (EE) was beneficial for neurological outcomes and that these effects might be mediated through SDF-1/CXCR4 pathway during the chronic stage of lobe epilepsy. These results revealed that although CXCR4 antagonist AMD3100 reversed the proliferation of neurogenesis, it did not abolish the cognitive improvement induced by EE. PMID: 28104461
    13. Our findings suggest that NRF-1 regulates the expression of CXCR4 in normal retinal development and in pathologic processes of retinal hypoxia and neovascularization. PMID: 28903152
    14. simulated microgravity disrupts cytoskeleton organization and increases apoptosis of rat Neural crest stem cells via upregulating CXCR4 expression and the RhoA-ROCK1-p38 MAPK-p53 signaling pathway. PMID: 27269634
    15. SDF1-CXCR4 signaling mediates the transition from acute pain to chronic pain state. PMID: 27011380
    16. CXCR4 overexpression can mobilize mesenchymal stem cells into ischemic area, whereby these cells can promoted angiogenesis and alleviate left ventricular remodeling remodeling via paracrine signaling mechanism. PMID: 28233339
    17. regulatory activity of molecular regulators of SDF-1alpha/CXCR4 on neural stem cell migration PMID: 26886751
    18. Satellite glial cells-neuronal cross-talk in hyperalgesia is mediated by SDF1-CXCR4 coupling. PMID: 26597700
    19. Enhances the anti-apoptotic effects of the BMSCs by upregulating the expression of SDF-1/CXCR4 axis. PMID: 26398409
    20. SDF-1/CXCR4 pathway seems to be involved in the enhancement of neurogenesis and behavioral recovery induced by post-stroke forced limb-use PMID: 26444377
    21. The CXCL12/CXCR4/PI3K/pAkt signalling pathway increased progesterone-induced endothelial progenitor cells viability. PMID: 26818151
    22. The expression of CXCR4 is increased in the cochlea in newborn animals following auditory stimulation. PMID: 26164455
    23. CXCR4 antagonism decreases lung inflammation and improves alveolar and vascular structure in neonatal rats with experimental bronchopulmonary dysplasia (BPD). PMID: 25825119
    24. This study examines the role of CXCR4 in cardiomyocyte response to ischaemia-reperfusion (I/R) injury. PMID: 25824297
    25. This study demonstrated a potentially reno-protective role for CXCR4 in diabetes that is impeded in its actions in the human kidney by the coincident up-regulation of ligand-inactivating endopeptidases. PMID: 25549045
    26. CXCR4 receptor overexpression in mesenchymal stem cells has a role in treatment of acute lung injury in rats PMID: 25492872
    27. Stromal-derived factor -1/CXCR4 can enhance the migration of bone marrow mesenchymal stem cells in vitro in a rat abdominal aortic aneurysm model. PMID: 24751384
    28. Findings indicate that CXCR-4 and -7 receptors were co-expressed in BMSCs and synergistically promoted BMSC migration. PMID: 24924806
    29. CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit cells in rats. PMID: 24587052
    30. Results suggest that endogenous endothelial progenitor cells (EPCs) participated in the neovascularization via CXCR4/SDF-1 axis after permanent middle cerebral artery occlusion and mobilizing endogenous EPCs could be a treatment alternative for stroke PMID: 24581269
    31. Local SDF-1/CXCR4 signaling functions to preserve microvascular integrity and prevent renal fibrosis. PMID: 24637920
    32. The SDF-1/CXCR4 axis regulates migration of transplanted bone marrow mesenchymal stem cells towards the pancreas in rats with acute pancreatitis. PMID: 24626964
    33. Over-expression CXCR4 leads to enhanced in vivo mobilization and engraftment of bone marrow-derived mesenchymal stem cells into inflamed colon. PMID: 24122226
    34. CXCR4 activation with SDF-1alpha and ubiquitin results in partially synergistic effects on cellular signaling. PMID: 24373940
    35. Migration and survival of ASCs could be improved by atorvastatin under ischemia-reperfusion injury, which were ascribed to SDF-1alpha/CXCR-4 axis. PMID: 24312447
    36. Mechanical allodynia is suppressed by inhibition of the CXCR4/SDF1-alpha system. PMID: 24557113
    37. CXCR4 and CXCR7 form a functional receptor unit in microglial cells, which is up-regulated during activation of microglia both in vitro and in vivo. PMID: 23289420
    38. following optic nerve crush, the levels of endogenous SDF-1alpha and CXCR4 increase in the retina and optic nerve, where activated glial cells may act as a source of increased SDF-1alpha protein. PMID: 23832528
    39. A positive correlation between microvessel density and the high expression of SDF1 and CXCR4 following hyperbaric oxygen treatment. PMID: 23969990
    40. Data indicate that Rehmannia glutinosa extract up-regulated the expression of angiogenesis-associated ligand/receptor, including CD133, VEGFR2 and SDF-1alpha/CXCR4. PMID: 23349848
    41. Evidence that the CXCL12/CXCR4 system is involved in modulation of nociceptive signalling. PMID: 22694179
    42. These findings indicate that the activation of CXCR4 may promote tracheal cell proliferation and migration to the sites of airway injury where SDF-1 is regulated. PMID: 23576796
    43. positive impact of Sdf-1 on muscle regeneration is related to the mobilisation of endogenous cells, that is satellite cells and myoblasts, as well as non-muscle stem cells, expressing Cxcr4 and CD34. PMID: 22978573
    44. Heparin oligosaccharides inhibit chemokine (CXC motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and competing with the chemokine (CXC motif) receptor 4 (CXCR4) N terminus PMID: 23148226
    45. Increased expression of CXCR4 in allograft mesenchymal stem cells is critical for myocardial neovascularization in rats with myocardial infarction. PMID: 23029422
    46. CXCR4 played a crucial role in the intimal hyperplasia after carotid artery injury, and restenosis may have be attenuated after inhibition of CD34(+)CXCR4(+) cells in the intima. PMID: 22159319
    47. CXCR4 overexpression in mesenchymal stem cells promotes their mobilization and enhanced neuroprotection in a rat cerebral ischemia model. PMID: 22280945
    48. CXCR4 is upregulated in a model of spatial learning and memory in trained rats indicating a positive correlation between CXCR4 expression and axonal sprouting. PMID: 22140095
    49. Sal B also obviously down-regulated the SDF-1alpha-stimulated up-regulation of CXCR4. PMID: 22166584
    50. Folliculostellate (FS) cells express chemokine CXCL12 and its receptor CXCR4. The CXCL12/CXCR4 axis evokes interconnection of FS cells. PMID: 22355073

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    STRING: 10116.ENSRNOP00000005143

    UniGene: Rn.44431