CLDN6
CLDN6位于染色体16p3.3,分子量大约20-40kDa。Claudins成员之间具有相似的结构,每个Claudin分子有4个跨膜结构域,2个细胞外环和2条胞内尾区。CLDN6拥有一个C端的PDZ结合位点,使得紧密连接蛋白能与细胞内某些蛋白发生相互作用关系,在细胞连接及上皮组织通透性等方面均可发挥重要作用
越来越多的研究表明,CLDN6异常表达可参与乳腺癌,卵巢癌,宫颈癌,胃癌,肺癌等多种恶性肿瘤发生及发展过程。CLDN6作为细胞骨架的形成和细胞信号通路调节的重要分子,可影响细胞的生长进程,这为肿瘤的诊断和干预提供了新的方向。目前,多款针对CLDN6的药物已处于临床和临床前阶段,用于多种肿瘤的治疗。
CUSABIO-哺乳包膜VIPs平台成功开发CLDN6全长跨膜蛋白(4次跨膜),展示了完整生物活性。
热销产品
● Recombinant Human Claudin-6(CLDN6)-VLPs (Active) (CSB-MP005508HU(A4))
CSB-MP005508HU(A4) is detected by Mouse anti-6*His monoclonal antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 at 10 μg/ml can bind Anti-CLDN6/9 recombinant antibody (CSB-RA005508MA1HU), the EC50 is 1.501-2.035 ng/mL
The presence of VLP-like structures was confirmed by TEM
● CLDN6/9 Recombinant Monoclonal Antibody CSB-RA005508MA1HU
The Binding Activity of Huamn CLDN6 with Anti-CLDN6/9 recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 (CSB-MP005508HU(A4)) at 10 μg/mL can bind Anti-CLDN6/9 recombinant antibody, the EC50 is 1.501-2.035 ng/mL.
The Binding Activity of Human CLDN9 with Anti-CLDN6/9 Recombinant Antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN9 (CSB-MP005511HU) at 10 μg/mL can bind Anti-CLDN6/9 recombinant antibody, the EC50 is 24.93-35.47 ng/mL.
Untransfected HEK293T cells (green line) and transfected Human CLDN6 HEK293T stable cells (red line) were stained with anti-CLDN6/9 recombinant antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
CLDN6 Antibodies
CLDN6 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA207788 | Phospho-CLDN6 (Tyr219) Antibody | Human,Mouse | ELISA,WB |
CSB-PA263732 | CLDN6 Antibody | Human | ELISA,WB,IHC,IF |
CSB-PA001673 | CLDN6 Antibody | Human | WB, IHC, IF, ELISA |
CSB-PA070220 | Phospho-CLDN6 (Y219) Antibody | Human,Mouse | WB, IHC, ELISA |
CSB-PA070221 | CLDN6 Antibody | Human,Mouse | IHC, ELISA |
CSB-PA005508LA01HU | CLDN6 Antibody | Human | ELISA, IHC, IF |
CSB-PA005508LB01HU | CLDN6 Antibody, HRP conjugated | Human | ELISA |
CSB-RA005508MA1HU | CLDN6/9 Recombinant Monoclonal Antibody | Human | ELISA,FC |
CLDN6 Proteins
CLDN6 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP005508HU1 CSB-EP005508HU1 CSB-BP005508HU1 CSB-MP005508HU1 CSB-EP005508HU1-B |
Recombinant Human Claudin-6 (CLDN6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP005508HU(A4) | Recombinant Human Claudin-6 (CLDN6)-VLPs (Active) | Mammalian cell |
CLDN6 Proteins for Homo sapiens(Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-CF005508HU | Recombinant Human Claudin-6 (CLDN6), partial | in vitro E.coli expression system |