先天性遗传性新生儿疾病和畸形
先天性遗传性新生儿疾病和畸形是由遗传因素引起的新生儿健康问题,这些疾病可能在出生时或生后的早期就已经存在。包括代谢性疾病、血液疾病、先天性心脏病、神经管缺陷等。
目前,先天性遗传性新生儿疾病和畸形的药物研发正在积极探索当中,主要集中在以下几个方向:
- 基因治疗:基因疗法是针对遗传性疾病的一种治疗方法,通过替换、修复或调控致病基因来治疗疾病。例如,针对先天性黑矇(一种遗传性视网膜疾病)的基因治疗研究正在进行,旨在通过基因疗法恢复受损的视网膜功能。
- 代谢性疾病治疗:对于代谢性疾病,研发的新药可能针对特定的代谢途径,如针对PKU的治疗方法,除了传统的饮食控制外,正在研究能够改善代谢途径的药物。
- 新生儿疾病筛查技术:随着串联质谱技术(MS/MS)和基因检测技术的发展,新生儿疾病筛查变得更加高效和准确,有助于早期诊断和干预。
先天性遗传性新生儿疾病和畸形药物靶点
- ABCA4
- ABCD1
- ALB
- ALPL
- ANGPTL3
- APOA1
- APP
- ARSA
- C1R
- C1S
- C5
- CD14
- CD200R1
- CD247
- CD276
- CD34
- CD40LG
- CFTR
- COL7A1
- CSF2
- CSF2RA
- CSF3R
- CYP4V2
- DAG1
- DMD
- DMPK
- DNA2
- DYSF
- ELANE
- EPOR
- F10
- F11
- F7
- F8
- F9
- FANCA
- FGFR3
- FKRP
- FSHR
- FXN
- GAA
- GALC
- GHR
- GLP1R
- HBB
- HEXA
- HEXB
- IDS
- IDUA
- IFNAR1
- IFNGR1
- IGF1R
- IGF2R
- IL11RA
- IL12A
- IL13
- IL17A
- IL18
- IL1A
- IL1B
- IL1R1
- IL1RL1
- IL2
- IL22
- IL25
- IL2RA
- IL2RG
- IL31
- IL33
- IL4
- IL4R
- IL6
- IL6R
- IL6ST
- INSR
- KIT
- KLK5
- KLK7
- KLKB1
- LEPR
- MECP2
- MT-ND4
- OTC
- PAH
- PCSK9
- PDCD1
- PGF
- PTCRA
- RHD
- RHO
- RPE65
- RPGR
- SELP
- SERPINA1
- SGSH
- SIRT6
- SNAP25
- SOST
- SPINK5
- TFPI
- TFRC
- TGFB1
- TNF
- TNFRSF1A
- TNFRSF4
- TNFSF4
- TSLP
- TTR
- UBE3A
- UGT1A1
- USH2A
- VEGFA
先天性遗传性新生儿疾病和畸形靶点相关产品推荐
● 靶点蛋白
Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.
Measured by its binding ability in a functional ELISA. Immobilized Human IL4 (CSB-MP011659HU) at 2μg/mL can bind biotinylated Human IL4R,the EC50 is 12.68-14.23 ng/mL.
CSB-MP023437HU
Measured by its binding ability in a functional ELISA. Immobilized Human TFPI at 1 μg/ml can bind Anti-TFPI recombinant antibody (CSB-RA023437MA01HU), the EC50 is 1.242-1.788 ng/mL.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP3648HU
Measured by its binding ability in a functional ELISA. Immobilized Human TFRC at 2μg/mL can bind Anti-TFRC recombinant antibody (CSB-RA023441MA1HU), the EC50 is 3.305-8.220 ng/mL.
CSB-MP009514HUb1
Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC50 is 54.54-94.23 ng/mL.
CSB-MP011649HU3
Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU),the EC50 is 2.463-3.353 ng/mL.
CSB-MP733578HU
Measured by its binding ability in a functional ELISA. Immobilized CD276 at 2 μg/ml can bind Anti-CD276 rabbit monoclonal antibody, the EC50 of human CD276 protein is 1.961-2.243 ng/ml.
● 重组抗体
CSB-RA011087MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA011087MA1HU (red line) at 1:50.
CSB-RA019677MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA019677MA1HU (red line) at 1:100.
CSB-RA011621MA1HU
Overlay Peak curve showing NIH/3T3 cells surface stained with CSB-RA011621MA1HU (red line) at 1:50.
CSB-RA003995MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA003995MA1HU (red line) at 1:800.
产品名称 | 货号 | 靶点 | 反应种属 | 应用范围 |
---|---|---|---|---|
ALB Recombinant Monoclonal Antibody | CSB-RA264109A0HU | ALB | Human | ELISA, FC |
APP Recombinant Monoclonal Antibody | CSB-RA994273A0HU | APP | Human, Mouse, Rat | ELISA, WB, IF |
C5 Recombinant Monoclonal Antibody | CSB-RA003995MA1HU | C5 | Human | ELISA, FC |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD34 Recombinant Monoclonal Antibody | CSB-RA004926A0HU | CD34 | Human | ELISA, IHC |
DMD Recombinant Monoclonal Antibody | CSB-RA271553A0HU | DMD | Human | ELISA, IHC |
ELANE Recombinant Monoclonal Antibody | CSB-RA200985A0HU | ELANE | Human | ELISA, IHC, FC |
F10 Recombinant Monoclonal Antibody | CSB-RA599469A0HU | F10 | Human | ELISA, IHC |
F9 Recombinant Monoclonal Antibody | CSB-RA923075A0HU | F9 | Human | ELISA, WB |
FGFR3 Recombinant Monoclonal Antibody | CSB-RA555849A0HU | FGFR3 | Human | ELISA, IF |
FGFR3 Recombinant Monoclonal Antibody | CSB-RA966627A0HU | FGFR3 | Human | ELISA, WB |
GAA Recombinant Monoclonal Antibody | CSB-RA566370A0HU | GAA | Human | ELISA, IHC |
GHR Recombinant Monoclonal Antibody | CSB-RA978909A0HU | GHR | Human | ELISA, IHC, IF |
GLP1R Recombinant Monoclonal Antibody | CSB-RA009514MA1HU | GLP1R | Human | ELISA |
IFNAR1 Recombinant Monoclonal Antibody | CSB-RA011046A0HU | IFNAR1 | Human | ELISA |
IGF1R Recombinant Monoclonal Antibody | CSB-RA011087MA1HU | IGF1R | Human | ELISA, FC |
IL17A Recombinant Monoclonal Antibody | CSB-RA624104MA1HU | IL17A | Human | ELISA |
IL1R1 Recombinant Monoclonal Antibody | CSB-RA011621MA1HU | IL1R1 | Human | ELISA, FC |
IL2RA Recombinant Monoclonal Antibody | CSB-RA011649MA1HU | IL2RA | Human | ELISA, IF |
IL4 Recombinant Monoclonal Antibody | CSB-RA240377A0HU | IL4 | Human | ELISA, IHC |
● ELISA试剂盒
产品名称 | 货号 | 靶点 | 检测范围 | 灵敏度 |
---|---|---|---|---|
Bovine Albumin(Alb) ELISA kit | CSB-E08664b | ALB | 0.313 μg/mL-80 μg/mL | 0.148 μg/mL |
Mouse Albumin (Alb)ELISA Kit | CSB-E13878m | ALB | 0.781 μg/mL-200 μg/mL | 0.110 μg/mL |
Dog Albumin(Alb) ELISA Kit | CSB-E15757c | ALB | 0.273 μg/mL-35 μg/mL | 0.266 μg/mL |
Sheep Albumin (Alb)ELISA Kit | CSB-E15839Sh | ALB | 350 μg/mL-21.88 μg/mL | 5.5 μg/mL |
Horse Albumin(Alb) ELISA Kit | CSB-E16205Hs | ALB | 1.25 μg/mL-80 μg/mL | 1.247 μg/mL |
Pig Albumin (Alb) ELISA Kit | CSB-E16207p | ALB | 0.03 μg/mL-7000 μg/mL | 0.03 μg/mL |
Goat Albumin (Alb)ELISA Kit | CSB-E15758G | ALB | 0.17 μg/mL-350 μg/mL | 0.17 μg/mL |
Guinea Pig Albumin(Alb) ELISA kit | CSB-E15765Gp | ALB | 0.156 μg/mL-10 μg/mL | 0.09 μg/mL |
Rabbit Albumin(Alb) ELISA Kit | CSB-E16204Rb | ALB | 0.273 μg/mL-70 μg/mL | 0.117 μg/mL |
Human angiopoietin-like protein 3,ANGPTL3 ELISA Kit | CSB-E11724h | ANGPTL3 | 78 pg/mL-5000 pg/mL | 19.5 pg/mL |
Mouse Angiopoietin-related protein 3(ANGPTL3) ELISA kit | CSB-EL001711MO | ANGPTL3 | 31.25 pg/mL-2000 pg/mL | 10.24 pg/mL |
Human apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E08103h | APOA1 | 1.4 ng/mL-1000 ng/mL | 0.7 ng/mL |
Rat apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E08105r | APOA1 | 0.14 ng/ml-100 ng/ml. | 0.14 ng/ml. |
Pig apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E06834p | APOA1 | 80 μg/mL-2000 μg/mL | 50 μg/mL |
Mouse apolipoprotein A1(Apo-A1) ELISA Kit | CSB-E08104m | APOA1 | 31.25 ng/mL-2000 ng/mL | 7.81 ng/mL |
Rabbit apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E09804Rb | APOA1 | 6.25 μg/mL-400 μg/mL | 1.56 μg/mL |
Bovine Apolipoprotein A-I(APOA1) ELISA kit | CSB-EL001913BO | APOA1 | 78 ng/mL-5000 ng/mL | 19.5 ng/mL |
Dog Apolipoprotein A-I(APOA1) ELISA kit | CSB-EL001913DO | APOA1 | 28.12 ng/mL-1800 ng/mL | 7 ng/mL |
Rat Amyloid beta A4 protein(APP) ELISA kit | CSB-EL001950RA | APP | 15.6 ng/mL-1000 ng/mL | 3.9 ng/mL |
Human Complement C1s subcomponent(C1S) ELISA kit | CSB-EL003657HU | C1S | 25 ng/mL-1600 ng/mL | 6.25 ng/mL |