UGT1A1

UGT1A1（UDP-葡萄糖醛酸转移酶1A1）是一种在人体代谢循环中发挥关键作用的酶，由染色体2q37上的基因编码。它是一种膜结合蛋白，具有跨膜区域和催化结构域，主要定位在内质网和高尔基体。UGT1A1的功能包括胆红素代谢，其中它负责将胆红素转化为水溶性的结合胆红素，以便排泄；药物代谢，特别是对抗癌药物伊立替康的代谢，通过催化其有毒代谢物SN-38的葡萄糖醛酸化，促进排泄，减少毒性；以及激素调节，参与雌激素和其他激素的代谢，影响激素水平的调节。UGT1A1参与的信号通路可能涉及药物代谢、胆红素代谢和激素信号传递等过程。UGT1A1的基因多态性对胆红素代谢、药物反应等有显著影响，不同基因型的个体在UGT1A1酶活性上可能存在显著差异，这对个体化治疗具有重要的临床意义。

热销产品

UGT1A1 Antibody (CSB-PA025570LA01HU)

验证数据

Western Blot
Positive WB detected in: Hela whole cell lysate,SY5Y whole cell lysate,PC-3 whole cell lysate,K562 whole cell lysate,MCF7 whole cell lysate,293 whole cell lysate,A549 whole cell lysate
All lanes: UGT1A1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 60 kDa
Observed band size: 60 kDa

Immunofluorescence staining of NIH/3T3 cell with CSB-PA025570LA01HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

UGT1A1 Antibody

UGT1A1 Protein