DLL3
DLL3（Delta-like protein 3），也被称为Delta样蛋白3，是一种在细胞信号传导中起作用的跨膜蛋白，它是Notch信号通路的成员之一，对于细胞分化和发育至关重要。LL3参与细胞间通讯，是Notch受体的配体之一。它与相邻细胞上的Notch受体相互作用，触发一个信号级联，可以影响细胞命运决策，包括细胞分化和增殖。DLL3在胚胎发育中尤其重要，特别是在神经系统的发育过程中。在小细胞肺癌（SCLC）中，DLL3通常被过度表达，这种过度表达被认为是一个潜在的治疗靶点。已经开发了几种实验性治疗方法，如抗体药物结合物（ADCs），以靶向SCLC细胞中的DLL3。了解DLL3在癌症细胞中的功能，有望推动对某些类型癌症更有针对性和有效的治疗方法的开发，为患者提供改善预后的希望。
● 更多相关阅读：DLL3：肺癌“网红”靶点，或成精准治疗新希望
热销产品
Recombinant Human Delta-like protein 3(DLL3),partial (Active) CSB-MP882142HU
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 at 2 μg/ml can bind Anti-DLL3 Recombinant Antibody（CSB-RA882142A1HU）, the EC50 is 1.102-1.707 ng/mL.
● Recombinant Macaca fascicularis Delta-like protein 3(DLL3),partial (Active) CSB-MP3536MOV
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 at 2 μg/ml can bind Anti-DLL3 Recombinant Antibody（CSB-RA882142A1HU）, the EC50 is 1.625-2.702 ng/mL.
● DLL3 Recombinant Monoclonal Antibody CSB-RA882142A1HU
验证数据
Untransfected HEK293 cells (green line) and transfected Human DLL3 HEK293 stable cells (red line) were stained with anti-DLL3 antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.
The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP3536MOV) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody (CSB-RA882142A1HU), the EC50 is 1.625-2.702 ng/mL.
The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP882142HU) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody (CSB-RA882142A1HU), the EC50 is 1.102-1.707 ng/mL.
DLL3 Antibodies
DLL3 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA882142LA01HU | DLL3 Antibody | Human | ELISA, IHC |
| CSB-PA882142LB01HU | DLL3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA882142LC01HU | DLL3 Antibody, FITC conjugated | Human | |
| CSB-PA882142LD01HU | DLL3 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA882142A1HU | DLL3 Recombinant Monoclonal Antibody | Human | ELISA, FC |
DLL3 Proteins
DLL3 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006948MO1 CSB-EP006948MO1 CSB-BP006948MO1 CSB-MP006948MO1 CSB-EP006948MO1-B |
Recombinant Mouse Delta-like protein 3 (Dll3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006948MO | Recombinant Mouse Delta-like protein 3 (Dll3) | in vitro E.coli expression system |
DLL3 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006948RA1 CSB-EP006948RA1 CSB-BP006948RA1 CSB-MP006948RA1 CSB-EP006948RA1-B |
Recombinant Rat Delta-like protein 3 (Dll3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006948RA | Recombinant Rat Delta-like protein 3 (Dll3) | in vitro E.coli expression system |
DLL3 Proteins for Xenopus laevis (African clawed frog)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP346574XBE CSB-EP346574XBE CSB-BP346574XBE CSB-MP346574XBE CSB-EP346574XBE-B |
Recombinant Xenopus laevis Homeobox protein DLL-3 (dll3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DLL3 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP882142HU | Recombinant Human Delta-like protein 3 (DLL3), partial | Yeast |
| CSB-EP882142HU | Recombinant Human Delta-like protein 3 (DLL3), partial | E.coli |
| CSB-EP882142HU1 | Recombinant Human Delta-like protein 3 (DLL3), partial | E.coli |
| CSB-MP882142HU | Recombinant Human Delta-like protein 3 (DLL3), partial (Active) | Mammalian cell |
| CSB-EP882142HU2-B | Recombinant Human Delta-like protein 3 (DLL3), partial,Biotinylated | E.coli |
| CSB-MP882142HU2 | Recombinant Human Delta-like protein 3 (DLL3), partial | Mammalian cell |
| CSB-MP882142HU2d7 | Recombinant Human Delta-like protein 3 (DLL3), partial | Mammalian cell |
| CSB-MP882142HU3 | Recombinant Human Delta-like protein 3 (DLL3), partial | Mammalian cell |
| CSB-MP882142HU3d7 | Recombinant Human Delta-like protein 3 (DLL3), partial | Mammalian cell |
DLL3 ELISA Kit
DLL3 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL006948HU | Human Delta-like protein 3(DLL3) ELISA kit | serum, plasma, tissue homogenates | 4.68 pg/mL |
