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IL4

IL4(白细胞介素4)是一种由Th2细胞产生的细胞因子,具有约35 kDa的分子量和由129个氨基酸组成的结构。它包含4个α螺旋,形成典型的细胞因子折叠结构。IL4在免疫调节、B细胞激活、细胞生长以及炎症反应中发挥关键作用。它通过与其受体结合,激活JAK-STAT信号通路,特别是通过JAK1和JAK3的激活,进而磷酸化并激活STAT6,导致其转移到细胞核并调节下游基因的表达。此外,IL4也能激活PI3K-AKT和MAPK信号通路,参与细胞生长和存活的调控。IL4的功能在多种疾病中具有重要作用,包括过敏性疾病、哮喘、慢性寄生虫感染和自身免疫疾病,以及在肿瘤发展中的双重作用。因此,IL4是维持免疫平衡和调节炎症反应中不可或缺的免疫调节因子。

IL4 Antibodies

IL4 for Homo sapiens (Human)

IL4 for Dog

IL4 Proteins

IL4 Proteins for Capra hircus (Goat)

IL4 Proteins for Ovis aries (Sheep)

IL4 Proteins for Equus caballus (Horse)

IL4 Proteins for Bos taurus (Bovine)

IL4 Proteins for Macaca mulatta (Rhesus macaque)

IL4 Proteins for Felis catus (Cat) (Felis silvestris catus)

IL4 Proteins for Mus musculus (Mouse)

IL4 Proteins for Homo sapiens (Human)

IL4 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

IL4 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

IL4 Proteins for Rattus norvegicus (Rat)

IL4 Proteins for Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)

IL4 Proteins for Cervus elaphus (Red deer)

IL4 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)

IL4 Proteins for Bubalus carabanensis (Swamp type water buffalo) (Bubalus bubalis carabanensis)

IL4 Proteins for Ailuropoda melanoleuca (Giant panda)

IL4 Proteins for Boselaphus tragocamelus (Nilgai)

IL4 Proteins for Mesocricetus auratus (Golden hamster)

IL4 Proteins for Papio anubis (Olive baboon)

IL4 Proteins for Bubalus bubalis (Domestic water buffalo)

IL4 Proteins for Lama glama (Llama)

IL4 Proteins for Pan troglodytes (Chimpanzee)

IL4 Proteins for Oryctolagus cuniculus (Rabbit)

IL4 Proteins for Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)

IL4 ELISA Kit

IL4 ELISA Kit for Bos taurus (Bovine)

IL4 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

IL4 ELISA Kit for Capra hircus (Goat)

IL4 ELISA Kit for Homo sapiens (Human)

IL4 ELISA Kit for Mus musculus (Mouse)

IL4 ELISA Kit for Sus scrofa (Pig)

IL4 ELISA Kit for Oryctolagus cuniculus (Rabbit)

IL4 ELISA Kit for Rattus norvegicus (Rat)

IL4 ELISA Kit for Ovis aries (Sheep)

IL4 ELISA Kit for Mesocricetus auratus (Golden hamster)