KLK5
KLK5是激肽释放酶家族中的一种丝氨酸蛋白酶,在人体中发挥着多重功能。它主要参与皮肤的生理脱屑过程,维持皮肤细胞的正常更新。然而,KLK5活性的上调可能引发连续的皮肤脱屑,激活蛋白酶激活受体-2(PAR2),导致促炎细胞因子的释放,从而破坏表皮屏障功能,与炎症性皮肤病的发展密切相关。此外,KLK5还可能通过剪切Cathelicidin产生活性形式LL-37,参与到玫瑰痤疮等疾病的免疫调节过程中。尽管其具体分子结构和直接参与的信号通路尚需深入研究,但KLK5在皮肤健康、细胞增殖、凋亡及免疫调节中的重要作用已不容忽视。
热销产品
KLK5 Antibody (CSB-PA897100LA01HU)
验证数据
Western blot
All lanes: KLK5 antibody at 2μg/ml + MCF-7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 32 kDa
Observed band size: 32 kDa
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA897100LA01HU at dilution of 1:100
KLK5 Antibodies
KLK5 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA012456GA01HU | KLK5 Antibody | Human | ELISA |
CSB-PA897100LA01HU | KLK5 Antibody | Human | ELISA, WB, IHC |
CSB-PA897100LC01HU | KLK5 Antibody, FITC conjugated | Human | |
CSB-PA175566 | KLK5 Antibody | Human,Mouse | ELISA,WB,IHC |
KLK5 Proteins
KLK5 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP897100HU CSB-EP897100HU CSB-BP897100HU CSB-MP897100HU CSB-EP897100HU-B |
Recombinant Human Kallikrein-5 (KLK5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLK5 ELISA Kit
KLK5 ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-EL012456HU | Human Kallikrein-5(KLK5) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates, saliva | 15.6 pg/mL |