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卵巢癌

卵巢癌是一种起源于女性卵巢的恶性肿瘤,根据组织来源不同,一般分为上皮性癌、生殖细胞恶性肿瘤、性索间质细胞肿瘤,其中上皮性癌是卵巢恶性肿瘤中最常见的类型,约占90%。由于卵巢位于盆腔深部,肿瘤早期无特异性的症状,患者在就诊时,多已为晚期,预后较差,严重威胁患者生命安全。

卵巢癌的治疗主要包括手术和化疗,手术目的是切除肿瘤、明确诊断、准确分期、判断预后和指导治疗。近年来,随着对卵巢癌基因分子层面认识的加深和靶向药物逐渐应用到临床,卵巢癌的精准治疗手段也越来越丰富。

PARP抑制剂是近年来在卵巢癌治疗中取得显著进展的一类药物,它们通过抑制PARP酶活性,对BRCA突变或同源重组修复缺陷(HRD)的卵巢癌细胞具有杀伤作用。目前,多种PARP抑制剂如奥拉帕利、尼拉帕利、帕米帕利等已获批用于卵巢癌的治疗,尤其在BRCA突变或HRD阳性的患者中显示出较好的疗效。此外,针对FRα的ADC药物索米妥昔单抗(mirvetuximab soravtansine,MIRV)在卵巢癌治疗中显示出一定的效果。

卵巢癌药物靶点相关产品推荐

● 靶点蛋白

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP007763HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP015044HUc9 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized MSLN at 2 μg/ml can bind Anti-MSLN rabbit monoclonal antibody, the EC50 of the MSLN protein is 2.657-3.177 ng/ml.

CSB-MP005508HU(A4) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 at 10 μg/ml can bind Anti-CLDN6/9 recombinant antibody (CSB-RA005508MA1HU), the EC50 is 1.501-2.035 ng/mL

CSB-MP004940HU Activity Verified

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

CSB-MP704410HU3c7 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized MUC16 at 10 μg/ml can bind MSLN (CSB-MP015044HUc9), the EC50 is 460.7-662.2 ng/ml.

CSB-MP006163HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.

产品名称 货号 靶点 来源 蛋白标签
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active) CSB-MP733578HU CD276 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human Claudin-6 (CLDN6)-VLPs (Active) CSB-MP005508HU(A4) CLDN6 Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Claudin-6 (CLDN6)-VLPs, Fluorescent (Active) CSB-MP005508HU(A4)f4 CLDN6 Mammalian cell C-terminal GFP-tagged (This tag can be tested only under denaturing conditions)
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) CSB-AP005301MO Ctla4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) CSB-MP007479HU EGFR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) CSB-MP007763HU ERBB2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial (Active) CSB-AP003871HU FGFR3 Mammalian cell C-terminal Fc-tagged
Recombinant Human Interleukin-15 receptor subunit alpha (IL15RA), partial (Active) CSB-AP004551HU IL15RA Mammalian cell C-terminal Fc-tagged
Recombinant Mouse Interleukin-15 receptor subunit alpha (Il15ra), partial (Active) CSB-AP004801MO Il15ra Mammalian cell C-terminal Fc-tagged
Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA), partial (Active) CSB-MP011649HU3 IL2RA Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Mesothelin (MSLN), partial (Active) CSB-MP015044HUc9 MSLN Mammalian cell N-terminal hFc-tagged

● 稳定细胞株

CSB-SC005508HU FACS

HEK293T/Human CLDN6 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293T cells (green line) and transfected Human CLDN6 HEK293T stable cells (red line) were stained with anti-CLDN6/9 antibody (CSB-RA005508MA1HU) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重组抗体

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU
CSB-RA878942MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU
CSB-RA006163MA1HU FC

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU FC

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

TOP1 Recombinant Monoclonal Antibody
CSB-RA792129A0HU
CSB-RA792129A0HU FC

Overlay histogram showing HepG2 cells stained with CSB-RA792129A0HU (red line) at 1:50.

产品名称 货号 靶点 反应种属 应用范围
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
CDH6 Recombinant Monoclonal Antibody CSB-RA005055MA1HU CDH6 Human ELISA
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody CSB-RA260392A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA1HU ERBB2 Human ELISA
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody CSB-RA588766A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA2HU ERBB2 Human ELISA, IHC
FGFR3 Recombinant Monoclonal Antibody CSB-RA555849A0HU FGFR3 Human ELISA, IF
FGFR3 Recombinant Monoclonal Antibody CSB-RA966627A0HU FGFR3 Human ELISA, WB
IFNAR1 Recombinant Monoclonal Antibody CSB-RA011046A0HU IFNAR1 Human ELISA
IL2RA Recombinant Monoclonal Antibody CSB-RA011649MA1HU IL2RA Human ELISA, IF
MUC16 Recombinant Monoclonal Antibody CSB-RA941216A0HU MUC16 Human ELISA, IHC
MUC16 Recombinant Monoclonal Antibody CSB-RA973154A0HU MUC16 Human ELISA, IHC
NT5E Recombinant Monoclonal Antibody CSB-RA978310A0HU NT5E Human ELISA, IHC
PDCD1 Recombinant Monoclonal Antibody CSB-RA240597A0HU PDCD1 Human ELISA, WB, IHC
TOP1 Recombinant Monoclonal Antibody CSB-RA792129A0HU TOP1 Human ELISA, WB, IHC, FC, IP
ZG16B Recombinant Monoclonal Antibody CSB-RA836195MA1HU ZG16B Human, Macaca fascicularis ELISA

● ELISA试剂盒

产品名称 货号 靶点 检测范围 灵敏度
Human Tyrosine-protein kinase receptor UFO (AXL) ELISA Kit CSB-EL002476HU AXL 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit CSB-EL002476MO AXL 31.25 pg/ml-2000 pg/ml 7.81 pg/ml
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human Soluble CD276,sCD276/sB7-H3 ELISA Kit CSB-E14285h CD276 3.12 ng/mL-200 ng/mL 0.78 ng/mL
Human soluble cluster of differentiation 28,sCD28 ELISA Kit CSB-E09296h CD28 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit CSB-EL004936MO CD40 Request Information Request Information
Human Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940HU CD47 3.12 pg/mL-200 pg/mL 0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940MO CD47 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E09171h CTLA4 125 pg/mL-8000 pg/mL 31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E13637m CTLA4 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Human epidermal growth factor receptor,EGFR ELISA Kit CSB-E12124h EGFR 0.312 ng/mL-20 ng/mL 0.019 ng/mL
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit CSB-E11161h ERBB2 0.156 ng/mL-10 ng/mL 0.04 ng/mL
Human Fibroblast growth factor receptor 3(FGFR3) ELISA kit CSB-EL008646HU FGFR3 62.5 pg/mL-4000 pg/mL 15.6 pg/mL
Human Folate receptor alpha(FOLR1) ELISA kit CSB-EL008784HU FOLR1 0.39 ng/ml - 25 ng/ml 0.09 ng/ml
Bovine Interleukin 12,IL-12 ELISA Kit CSB-E14010B IL12A 6.25 pg/mL-400 pg/mL 1.56 pg/mL
Human Interleukin-15 receptor subunit alpha(IL15RA) ELISA kit CSB-EL011594HU IL15RA 31.25 pg/mL-2000 pg/mL 7.8 pg/mL
Human soluble interleukin-2 receptor,IL-2sRα ELISA kit CSB-E04629h IL2RA 78 pg/mL-5000 pg/mL 19.5 pg/mL
Mouse soluble interleukin-2 receptor,sIL-2Rα ELISA kit CSB-E07440m IL2RA 15.6 pg/ml - 1000 pg/ml 3.9 pg/ml