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世界甲状腺日:呵护颈部的“蝴蝶”

世界甲状腺日

自2008年起,国际甲状腺联盟(ITF)将每年的5月25日定为世界甲状腺日(World Thyroid Day),该节日所在的一周为“国际甲状腺知识宣传周”,旨在提升公众对甲状腺健康重要性的认识,并促进全球范围内对甲状腺疾病的研究与防治。2024年的主题为“甲状腺疾病是非传染性疾病”。

甲状腺,这个位于颈部前方的微小蝴蝶状腺体,虽然体积不大,对于调节人体新陈代谢速率、影响生长发育乃至情绪平衡至关重要,其分泌的甲状腺激素(T3与T4)触及全身每个细胞,确保能量的有效利用。

甲状腺疾病是一系列影响甲状腺功能的病症,大致可分为两大类:一类是甲状腺激素产生过多或过少导致的功能性异常,另一类是甲状腺结构本身的改变,如结节或肿瘤。

探究这些疾病的根源,科学家们发现其发病机制错综复杂,涉及遗传因素、环境条件与自身免疫反应的相互作用。例如,Graves病(毒性弥漫性甲状腺肿)中,免疫系统错误攻击甲状腺,引发过度活跃;相反地,桥本甲状腺炎则是甲状腺遭受自身免疫系统破坏,导致激素生产不足。此外,碘摄入不当与特定化学物质暴露亦被视为风险因素之一。

近年来,甲状腺疾病治疗药物的研发聚焦于针对性更强、副作用更小的新型药物开发,特别是针对自身免疫性甲状腺疾病和甲状腺癌的创新疗法。比如,针对Graves病中TSH受体抗体的新型拮抗剂开发,以精准阻断过度活跃的甲状腺刺激;甲状腺眼病领域,Tepezza的成功引入为通过抑制IGF-1R缓解症状树立了新标杆,并激励了对更多创新靶点的探索。此外,研究还着重于探索甲状腺癌的靶向治疗,如针对VEGFR、BRAF突变的酪氨酸激酶抑制剂。

j9九游会登录入口首页生物长期致力于为科研工作者提供高质量的蛋白、抗体、ELISA试剂盒等工具类科研试剂产品,鉴于甲状腺疾病研究的重要性与迫切性,在此特别整理了一系列与甲状腺疾病研究相关的20余种热门靶点及相关试剂产品列举如下,供您选择:

甲状腺研究相关ELISA试剂盒:

产品名称 货号 靶点 检测范围 灵敏度
Human Serine/threonine-protein kinase B-raf(BRAF) ELISA kit CSB-EL002791HU BRAF 31.25 pg/mL-2000 pg/mL 7.8 pg/mL
Mouse C-Reactive Protein,CRP ELISA Kit CSB-E07923m(1) CRP 5 ng/mL-4000 ng/mL 5 ng/mL
Rabbit C-Reactive Protein,CRP ELISA Kit CSB-E06847Rb CRP 7.8 pg/mL-2000 pg/mL 2 pg/mL
Rat C-Reactive Protein,CRP ELISA Kit CSB-E07922r CRP 31.25 ng/mL-2000 ng/mL 7.81 ng/mL
Mouse C-Reactive Protein,CRP ELISA Kit CSB-E07923m CRP 15.6 ng/mL-1000 ng/mL 3.9 ng/mL
Pig C-reactive protein,CRP ELISA Kit CSB-E08163p CRP 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Bovine C-reactive protein,CRP ELISA Kit CSB-E08577b CRP 1.25 ng/mL-80 ng/mL 1.25 ng/mL
Canine C-Reactive Protein,CRP ELISA Kit CSB-E14262c CRP 0.312 μg/mL-20 μg/mL 0.078 μg/mL
Sheep C-reactive protein(CRP) ELISA Kit CSB-E15081Sh CRP 0.625 μg/mL-40 μg/mL 0.156 μg/mL
Hamster C-reactive protein(CRP) ELISA Kit CSB-EL005991HA CRP 12.5 ng/mL-800 ng/mL 3.12 ng/mL
Human Catenin beta-1 (CTNNB1/CTNNB/OK/SW-cl.35/PRO2286) ELISA kit CSB-E08963h CTNNB1 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse β-catenin,β-cat ELISA Kit CSB-E11307m CTNNB1 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human epidermal growth factor receptor,EGFR ELISA Kit CSB-E12124h EGFR 0.312 ng/mL-20 ng/mL 0.019 ng/mL
Mouse Insulin-like growth factor 1,IGF-1 ELISA Kit CSB-E04581m IGF1 0.156 ng/mL-10 ng/mL 0.151 ng/mL
Rat Insulin-like growth factor 1,IGF-1 ELISA Kit CSB-E04582r IGF1 0.156 ng/mL-10 ng/mL 0.151 ng/mL
Pig insulin-like growth factors-1,IGF-1 ELISA Kit CSB-E06829p IGF1 6.25 ng/mL-400 ng/mL 1.56 ng/mL
Rabbit Insulin-like growth factor 1,IGF-1 ELISA Kit CSB-E06994Rb IGF1 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Bovine Insulin-like growth factor 1,IGF-1 ELISA Kit CSB-E08893b IGF1 0.75 ng/mL-60 ng/mL 0.94 ng/mL
Chicken Insulin-like growth factors 1,IGF-1 ELISA Kit CSB-E09867Ch IGF1 125 pg/mL-2000 pg/mL 125 pg/mL
Sheep insulin-like growth factor 1,IGF-1 ELISA Kit CSB-E13753Sh IGF1 15.6 ng/mL-1000 ng/mL 3.9 ng/mL

甲状腺研究相关重组蛋白:

产品名称 货号 靶点 来源 蛋白标签
Recombinant Mouse Thyrotropin receptor (Tshr), partial CSB-BP025131MO Tshr Baculovirus N-terminal 6xHis-tagged
Recombinant Marmota monax Tumor necrosis factor (TNF), partial CSB-BP523593MQG TNF Baculovirus N-terminal 10xHis-tagged
Recombinant Human Catenin beta-1 (CTNNB1) CSB-EP006169HU CTNNB1 E.coli N-terminal GST-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial CSB-EP007479HU3 EGFR E.coli N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
Recombinant Human Interleukin-6 (IL6) CSB-EP011664HU IL6 E.coli N-terminal 6xHis-tagged
Recombinant Sheep Interleukin-6 (IL6) CSB-EP011664SH IL6 E.coli N-terminal GST-tagged
Recombinant Human GTPase KRas (KRAS), partial CSB-EP012493HU1 KRAS E.coli N-terminal 6xHis-tagged
Recombinant Human Homeobox protein Nkx-2.1 (NKX2-1) CSB-EP015841HU NKX2-1 E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Paired box protein Pax-8 (PAX8) CSB-EP017494HU PAX8 E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Telomerase reverse transcriptase (TERT), partial CSB-EP023391HU TERT E.coli N-terminal 6xHis-tagged
Recombinant Mouse Telomerase reverse transcriptase (Tert), partial CSB-EP023391MO Tert E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Rat Thyroglobulin (Tg), partial CSB-EP023442RA Tg E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Bovie Tumor necrosis factor (TNF), partial CSB-EP023955BO TNF E.coli N-terminal 6xHis-tagged
Recombinant Bovie Tumor necrosis factor (TNF), partial CSB-EP023955BOe0 TNF E.coli N-terminal GST-tagged
Recombinant Human Tumor necrosis factor (TNF), partial CSB-EP023955HU TNF E.coli N-terminal 6xHis-tagged
Recombinant Mouse Tumor necrosis factor (Tnf), partial CSB-EP023955MO1 Tnf E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Sheep Tumor necrosis factor (TNF), partial CSB-EP023955SH TNF E.coli N-terminal GST-tagged
Recombinant Human Cellular tumor antigen p53 (TP53) CSB-EP024077HU TP53 E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Mouse Cellular tumor antigen p53 (Tp53) CSB-EP024077MO Tp53 E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Pig Vascular endothelial growth factor A (VEGFA) CSB-EP025833PI VEGFA E.coli N-terminal 6xHis-tagged

甲状腺研究相关抗体:

● 重组抗体:

产品名称 货号 靶点 反应种属 应用范围
Phospho-BRAF (T401) Recombinant Monoclonal Antibody CSB-RA002791A401phHU BRAF Human ELISA, WB, IF
BRAF Recombinant Monoclonal Antibody CSB-RA171021A0HU BRAF Human ELISA, IHC
CRP Recombinant Monoclonal Antibody CSB-RA988767A0HU CRP Human ELISA, IHC
Phospho-CTNNB1 (S33/S37) Recombinant Monoclonal Antibody CSB-RA006169A33phHU CTNNB1 Human ELISA, IF
CTNNB1 Recombinant Monoclonal Antibody CSB-RA155605A0HU CTNNB1 Human ELISA, IHC
CTNNB1 Recombinant Monoclonal Antibody CSB-RA006169MA1HU CTNNB1 Human ELISA, IHC, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC
IL6 Recombinant Monoclonal Antibody CSB-RA011664MA1HU IL6 Human ELISA
INS Recombinant Monoclonal Antibody CSB-RA584163A0HU INS Human ELISA, IHC
Phospho-MTOR (S2481) Recombinant Monoclonal Antibody CSB-RA008968A2481phHU MTOR Human ELISA, WB, IF
Phospho-MTOR (S2448) Recombinant Monoclonal Antibody CSB-RA008968A2448phHU MTOR Human ELISA, WB, IHC, IF
NKX2-1 Recombinant Monoclonal Antibody CSB-RA181189A0HU NKX2-1 Human ELISA, WB, IHC, FC
PAX8 Recombinant Monoclonal Antibody CSB-RA248028A0HU PAX8 Human ELISA, IHC
Phospho-PTEN (S380) Recombinant Monoclonal Antibody CSB-RA018964A380phHU PTEN Human ELISA, WB
RET Recombinant Monoclonal Antibody CSB-RA288083A0HU RET Human ELISA, FC
TERT Recombinant Monoclonal Antibody CSB-RA798840A0HU TERT Human ELISA, IHC

● 单克隆抗体:

产品名称 货号 靶点 反应种属 应用范围
CRP Monoclonal Antibody CSB-MA027411E0m CRP Human ELISA, IHC
CTNNB1 Monoclonal Antibody CSB-MA000223 CTNNB1 Human,Mouse,Rat ELISA, WB, IHC
CTNNB1 Monoclonal Antibody CSB-MA080197 CTNNB1 Human,Mouse,Rat ELISA, WB, IHC
CTNNB1 Monoclonal Antibody CSB-MA922448 CTNNB1 Human,Mouse,Rat ELISA, WB, IHC
CTNNB1 Monoclonal Antibody CSB-MA907551 CTNNB1 Human ELISA, IHC
EGFR Monoclonal Antibody CSB-MA000199 EGFR Human ELISA, WB, IHC, IF
EGFR Monoclonal Antibody CSB-MA000293 EGFR Human ELISA, WB
IL6 Monoclonal Antibody CSB-MA067571A0m IL6 Human ELISA, WB, IHC
PTH Monoclonal Antibody CSB-MA0189871A0m PTH Human ELISA
TNF Monoclonal Antibody CSB-MA084771A0m TNF Bovine ELISA
TNF Monoclonal Antibody CSB-MA080271 TNF Human,Mouse,Rat ELISA, WB, IHC
TNF Monoclonal Antibody CSB-MA080272 TNF Human,Mouse,Rat ELISA, WB, IHC
TP53 Monoclonal Antibody CSB-MA0240771A0m TP53 Human ELISA, WB, IHC
TP53 Monoclonal Antibody CSB-MA000208 TP53 Human ELISA, WB, IHC, IF
TP53 Monoclonal Antibody CSB-MA989534 TP53 Human ELISA, WB
TP53 Monoclonal Antibody CSB-MA189580 TP53 Human,Dog,Mouse,Rat ELISA, WB

● 多克隆抗体:

产品名称 货号 靶点 反应种属 应用范围
BRAF Antibody CSB-PA002791LA01HU BRAF Human ELISA, IHC, IF
BRAF Antibody CSB-PA003928 BRAF Human, Mouse, Rat ELISA, WB, IHC
BRAF Antibody CSB-PA003929 BRAF Human, Mouse ELISA, WB, IHC, IF
Phospho-BRAF (S602) Antibody CSB-PA050147 BRAF Human, Mouse, Rat ELISA, WB, IHC
Phospho-BRAF (T753) Antibody CSB-PA050146 BRAF Human, Mouse, Rat ELISA, WB
Phospho-BRAF (T599) Antibody CSB-PA050149 BRAF Human, Mouse, Rat ELISA, IHC
BRAF Antibody CSB-PA050150 BRAF Human, Mouse, Rat ELISA, WB
BRAF Antibody CSB-PA050151 BRAF Human, Mouse, Rat ELISA, IHC
Phospho-BRAF (S446) Antibody CSB-PA050148 BRAF Human, Mouse ELISA, WB, IHC
BRAF Antibody CSB-PA050152 BRAF Human, Mouse ELISA, WB, IHC
BRAF Antibody CSB-PA587286 BRAF Human, Mouse ELISA, WB, IHC
BRAF Antibody CSB-PA163656 BRAF Human, Mouse ELISA, WB, IHC
BRAF Antibody CSB-PA179620 BRAF Human, Mouse ELISA, WB, IHC
BRAF (Ab-753) Antibody CSB-PA921529 BRAF Human, Mouse ELISA, WB
BRAF (Ab-446) Antibody CSB-PA134950 BRAF Human, Mouse ELISA, WB, IHC
Phospho-BRAF (Ser446) Antibody CSB-PA575128 BRAF Human, Mouse ELISA, WB
Phospho-BRAF (Thr753) Antibody CSB-PA985068 BRAF Human, Mouse, Rat ELISA, WB
Phospho-BRAF (Thr599) Antibody CSB-PA243682 BRAF Human, Mouse, Rat ELISA, IHC
CCDC6 Antibody CSB-PA623068LA01HU CCDC6 Human ELISA, WB, IHC, IF
CRP Antibody CSB-PA06079A0Rb CRP Human ELISA, WB, IHC