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世界帕金森病日:不再惧“帕”

世界帕金森病日

欧洲帕金森病联盟(EPDA)从1997年开始,将每年的4月11日定为世界帕金森病日(World Parkinson's Disease Day),这一天是帕金森病的发现者--英国外科医生詹姆斯·帕金森博士的诞辰日,设立这一国际日旨在提高全球公众对这种慢性神经退行性疾病的认识,并推动相关研究的深入发展。2024年世界帕金森病日的主题是“和谐共生,美好生活”。

帕金森病(Parkinson's Disease, PD),以其标志性的运动障碍如静止性震颤、肌强直、运动迟缓和姿势不稳而广为人知,是一种中老年人群中常见的神经系统变性疾病。目前全球有超过1000万人患有帕金森病,随着全球老龄化进程的加快,帕金森病的患病率呈现上升趋势,预计到2050年,全球帕金森病患者人数将增加一倍,达到2000万。帕金森病对患者生活质量造成了严重影响,给社会带来了沉重的医疗负担。(想要了解更多关于帕金森病的内容?

发病机制方面,帕金森病的核心病理特征包括黑质区域多巴胺能神经元的丧失以及路易小体(Lewy bodies)的形成,这些异常结构主要由错误折叠的α-突触核蛋白聚集而成。尽管病因尚未完全明确,但遗传因素、环境毒素暴露、氧化应激、线粒体功能障碍和炎症反应等被认为是可能的致病诱因。近年来的研究逐渐揭示了帕金森病复杂而多元的病理生理过程,涉及神经保护、神经再生、免疫调节等诸多领域。

截至目前,尚无药物能够治愈帕金森病,抗帕金森病药物研发方向仍以对症治疗为主。近年来,虽然在帕金森病的基础研究和临床治疗方面取得了不少进展,但仍然需要更多的科学研究来理解该病的根本原因,以便开发出能够阻止或逆转疾病进展的新药。随着基础医学研究的不断进步,针对帕金森病的治疗策略已不再局限于传统的多巴胺替代疗法,而是逐渐向更深层次的病理机制探索和靶向治疗发展。

j9九游会登录入口首页生物长期致力于为科研工作者提供高质量的蛋白、抗体、ELISA试剂盒等工具类科研试剂产品,鉴于帕金森病研究的重要性与迫切性,在此特别整理了一系列与帕金森病研究相关的20余种热门靶点及相关试剂产品列举如下,供您选择:

帕金森病研究相关ELISA试剂盒:

产品名称 货号 靶点 检测范围 灵敏度
人RACα丝氨酸/苏氨酸蛋白激酶(AKT1)酶联免疫试剂盒 CSB-EL001553HU AKT1 0.312 ng/mL-20 ng/mL 0.078 ng/mL
人载脂蛋白E(Apo-E)酶联免疫试剂盒 CSB-E09748h APOE 15.62 ng/mL-1000 ng/mL 3.9 ng/mL
大鼠载脂蛋白E(Apo-E)酶联免疫试剂盒 CSB-E09749r APOE 15.6 ng/mL-1000 ng/mL 15.6 ng/mL
小鼠载脂蛋白E(Apo-E)酶联免疫试剂盒 CSB-E09750m APOE 6.25 ng/mL-400 ng/mL 1.56 ng/mL
猪载脂蛋白E(Apo-E)酶联免疫试剂盒 CSB-E17889p APOE 31.25 ng/mL-2000 ng/mL 7.81 ng/mL
猴载脂蛋白E(APOE)酶联免疫试剂盒 CSB-EL001936RH APOE 6.25 ng/mL-400 ng/mL 1.56 ng/mL
大鼠淀粉样βA4蛋白(APP)酶联免疫试剂盒 CSB-EL001950RA APP 15.6 ng/mL-1000 ng/mL 3.9 ng/mL
人脑源性神经营养因子(BDNF)酶联免疫试剂盒 CSB-E04501h BDNF 0.3125 ng/mL-20 ng/mL 0.063 ng/mL
大鼠脑源性神经营养因子(BDNF)酶联免疫试剂盒 CSB-E04504r BDNF 0.312 ng/mL-20 ng/mL 0.078 ng/mL
小鼠脑源性神经营养因子(BDNF)酶联免疫试剂盒 CSB-E04505m BDNF 15.6 pg/mL-1000 pg/mL 1.95 pg/mL
猪脑源性神经营养因子(BDNF)酶联免疫试剂盒 CSB-EL002655PI BDNF 9.375 ng/mL-600 ng/mL 2.35 ng/mL
猴脑源性神经营养因子(BDNF)酶联免疫试剂盒 CSB-EL002655RH BDNF 0.78 ng/mL-50 ng/mL 0.195 ng/mL
小鼠白介素1α(IL-1α)酶联免疫试剂盒 CSB-E04621m IL1A 2.35 pg/ml - 150 pg/ml 0.58 pg/ml
人白介素1α(IL-1α )酶联免疫试剂盒 CSB-E04620h IL1A 31.25 pg/mL-2000 pg/mL 7.8 pg/mL
大鼠白介素1α(IL-1α)酶联免疫试剂盒 CSB-E04622r IL1A 78 pg/ml-5000 pg/ml. 19.5 pg/ml.
猪白介素1α(IL-1α)酶联免疫试剂盒 CSB-E09725p IL1A 25 pg/mL-1600 pg/mL 6.25 pg/mL
猴白介素1a(IL1A)酶联免疫试剂盒 CSB-E10041Mo IL1A 7.8 pg/mL-500 pg/mL 1.95 pg/mL
人白介素6(IL-6)酶联免疫试剂盒 CSB-E04638h IL6 7.8 pg/mL-500 pg/mL 2.453 pg/mL
小鼠白介素6(IL-6)酶联免疫试剂盒 CSB-E04639m-IS IL6 3.9 pg/ml-250 pg/ml 0.975 pg/ml
小鼠白介素6(IL-6)酶联免疫试剂盒 CSB-E04639m IL6 Request Information Request Information

帕金森病研究相关重组蛋白:

产品名称 货号 靶点 来源 蛋白标签
Recombinant Mouse Apolipoprotein E (Apoe) CSB-BP001936MO Apoe Baculovirus N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human E3 ubiquitin-protein ligase parkin (PRKN) CSB-BP017451HU PRKN Baculovirus N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Marmota monax Tumor necrosis factor (TNF), partial CSB-BP523593MQG TNF Baculovirus N-terminal 10xHis-tagged
Recombinant Human RAC-alpha serine/threonine-protein kinase (AKT1) CSB-EP001553HU AKT1 E.coli N-terminal GST-tagged
Recombinant Mouse Apolipoprotein E (Apoe) CSB-EP001936MO Apoe E.coli N-terminal 6xHis-tagged
Recombinant Rabbit Apolipoprotein E (APOE), partial CSB-EP001936RB APOE E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Rabbit Apolipoprotein E (APOE), partial CSB-EP001936RBb3 APOE E.coli N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
Recombinant Rabbit Apolipoprotein E (APOE), partial CSB-EP001936RBb7 APOE E.coli N-terminal 10xHis-B2M-tagged and C-terminal Myc-tagged
Recombinant Human Brain-derived neurotrophic factor (BDNF) CSB-EP002655HU BDNF E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human Brain-derived neurotrophic factor (BDNF), partial CSB-EP002655HU1 BDNF E.coli N-terminal GST-tagged
Recombinant Human Interleukin-1 alpha (IL1A) CSB-EP011613HU IL1A E.coli N-terminal 6xHis-tagged
Recombinant Human Interleukin-1 alpha (IL1A) CSB-EP011613HUe0 IL1A E.coli N-terminal GST-tagged
Recombinant Macaca mulatta (Rhesus macaque) Interleukin-1 alpha(IL1A) CSB-EP011613MOW IL1A E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human Interleukin-6 (IL6) CSB-EP011664HU IL6 E.coli N-terminal 6xHis-tagged
Recombinant Sheep Interleukin-6 (IL6) CSB-EP011664SH IL6 E.coli N-terminal GST-tagged
Recombinant Human Amine oxidase [flavin-containing] B (MAOB), partial CSB-EP013399HU MAOB E.coli N-terminal 6xHis-tagged
Recombinant Macaca mulatta Microtubule-associated protein tau (MAPT) CSB-EP013481MOW MAPT E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Rat Microtubule-associated protein tau (Mapt) CSB-EP013481RA Mapt E.coli N-terminal 6xHis-tagged
Recombinant Human E3 ubiquitin-protein ligase parkin (PRKN) CSB-EP017451HU PRKN E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human Alpha-synuclein (SNCA), partial CSB-EP021912HU1 SNCA E.coli N-terminal GST-tagged

帕金森病研究相关抗体:

● 重组抗体:

产品名称 货号 靶点 反应种属 应用范围
Phospho-AKT1 (T450) Recombinant Monoclonal Antibody CSB-RA001553A450phHU AKT1 Human ELISA, WB
Phospho-AKT1 (Ser473) Recombinant Monoclonal Antibody CSB-RA001553A473phHU AKT1 Human ELISA, WB, IHC, IF, IP
AKT1 Recombinant Monoclonal Antibody CSB-RA917625A0HU AKT1 Human, Mouse, Rat ELISA, WB, IHC, IF
APP Recombinant Monoclonal Antibody CSB-RA994273A0HU APP Human, Mouse, Rat ELISA, WB, IF
BDNF Recombinant Monoclonal Antibody CSB-RA989910A0HU BDNF Human, Mouse ELISA, WB
IL6 Recombinant Monoclonal Antibody CSB-RA011664MA1HU IL6 Human ELISA
INS Recombinant Monoclonal Antibody CSB-RA584163A0HU INS Human ELISA, IHC
LRRK2 Recombinant Monoclonal Antibody CSB-RA797150A0HU LRRK2 Human ELISA, IHC
MAOB Recombinant Monoclonal Antibody CSB-RA999377A0HU MAOB Human ELISA, WB, IHC
Phospho-MAPT (T231) Recombinant Monoclonal Antibody CSB-RA013481A231phHU MAPT Human ELISA, WB
Phospho-MAPT (S396) Recombinant Monoclonal Antibody CSB-RA013481A396phHU MAPT Human ELISA, WB
Phospho-MAPT (S324) Recombinant Monoclonal Antibody CSB-RA013481A324phHU MAPT Human ELISA, IF
MAPT Recombinant Monoclonal Antibody CSB-RA246354A0HU MAPT Human ELISA, IHC
MAPT Recombinant Monoclonal Antibody CSB-RA013481A1HU MAPT Mouse,  Macaca mulatta ELISA
Phospho-MAPT (S199) Recombinant Monoclonal Antibody CSB-RA051594A0HU MAPT Human ELISA, IHC, FC
Phospho-MAPT (S404) Recombinant Monoclonal Antibody CSB-RA901354A0HU MAPT Human ELISA, IHC
Phospho-MAPT (S214) Recombinant Monoclonal Antibody CSB-RA050476A0HU MAPT Human ELISA, IHC
Phospho-MAPT (S202) Recombinant Monoclonal Antibody CSB-RA082445A0HU MAPT Human ELISA, FC
MAPT Recombinant Monoclonal Antibody CSB-RA013481MA1HU MAPT Human ELISA, FC
Phospho-SNCA (S129) Recombinant Monoclonal Antibody CSB-RA021912A129phHU SNCA Human ELISA, IHC, IF
SNCA Recombinant Monoclonal Antibody CSB-RA585595A0HU SNCA Human ELISA, IHC
SNCA Recombinant Monoclonal Antibody CSB-RA021912MA1HU SNCA Human ELISA, IHC, IF, FC
SOD1 Recombinant Monoclonal Antibody CSB-RA829583A0HU SOD1 Human ELISA, WB, FC
SOD1 Recombinant Monoclonal Antibody CSB-RA022397MA1HU SOD1 Human ELISA, IF, FC

● 单克隆抗体:

产品名称 货号 靶点 反应种属 应用范围
AKT1 Monoclonal Antibody CSB-MA011037 AKT1 Human,Mouse,Pig,Rat ELISA, WB
APP Monoclonal Antibody CSB-MA0019501A0m APP Human, Mouse ELISA, WB, IHC, IF
IL6 Monoclonal Antibody CSB-MA067571A0m IL6 Human ELISA, WB, IHC
TNF Monoclonal Antibody CSB-MA084771A0m TNF Bovine ELISA
TNF Monoclonal Antibody CSB-MA080271 TNF Human,Mouse,Rat ELISA, WB, IHC
TNF Monoclonal Antibody CSB-MA080272 TNF Human,Mouse,Rat ELISA, WB, IHC

● 多克隆抗体:

产品名称 货号 靶点 反应种属 应用范围
AKT1 Antibody CSB-PA15905A0Rb AKT1 Human ELISA, WB, IHC, IF, IP
AKT1 Antibody CSB-PA000852 AKT1 Human, Mouse, Rat ELISA, WB, IHC, IF
Phospho-AKT1 (S124) Antibody CSB-PA008118 AKT1 Human, Mouse, Rat ELISA, WB, IHC
Phospho-AKT1 (T72) Antibody CSB-PA008120 AKT1 Human, Mouse, Rat ELISA, WB, IHC
AKT1 Antibody CSB-PA008122 AKT1 Human, Mouse, Rat ELISA, IHC
AKT1 Antibody CSB-PA080256 AKT1 Human, Mouse, Rat WB
Phospho-AKT1 (S129) Antibody CSB-PA000645 AKT1 Human, Mouse, Rat ELISA, WB
Phospho-AKT1 (T308) Antibody CSB-PA000657 AKT1 Human, Mouse, Rat ELISA, WB
Phospho-AKT1 (S473) Antibody CSB-PA000732 AKT1 Human, Mouse, Rat ELISA, WB, IHC, IF
AKT1 Antibody CSB-PA000851 AKT1 Human, Mouse, Rat, Monkey ELISA, WB, IHC, IF
Phospho-AKT1 (S246) Antibody CSB-PA000465 AKT1 Human, Mouse, Rat ELISA, WB, IHC, IF
Phospho-AKT1 (T450) Antibody CSB-PA000468 AKT1 Human, Mouse, Rat ELISA, WB, IHC
Phospho-AKT1 (Y326) Antibody CSB-PA000649 AKT1 Human, Mouse, Rat ELISA, WB
Phospho-AKT1 (Y474) Antibody CSB-PA000704 AKT1 Human, Mouse, Rat, Monkey ELISA, WB, IHC
AKT1 Antibody CSB-PA000855 AKT1 Human, Mouse, Rat ELISA, WB, IHC
AKT1 Antibody CSB-PA000849 AKT1 Human, Mouse, Rat ELISA, WB, IHC
AKT1 Antibody CSB-PA001553GA01HU AKT1 Human ELISA, WB
AKT1 Antibody CSB-PA098004 AKT1 Human, Mouse, Rat ELISA, IHC
AKT1 Antibody CSB-PA721992 AKT1 Human, Mouse, Rat ELISA, WB
AKT1 Antibody CSB-PA942120 AKT1 Human, Mouse, Rat ELISA, WB