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PPP2R3B Antibody

  • 货号：
    CSB-PA896533ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PPP2R3B antibody at 2.1µg/ml + HL60 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 66, 21 kDa
      Observed band size: 66 kDa
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA896533ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA896533ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    The PPP2R3B polyclonal antibody (CSB-PA896533ESR2HU) is produced in rabbits immunized with the recombinant human PPP2R3B protein (356-575AA). It occurs as an unconjugated IgG. It underwent antigen affinity purification and reached a relatively high purity. And it only reacts with human PPP2R3B protein, a protein phosphatase 2A regulatory subunit that interacts with the origin of replication component, CDC6, and has been linked to regulation of autophagy. This PPP2R3B antibody has been quality tested in ELISA, WB, and IHC applications.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PPP2R3B Polyclonal antibody
  • Uniprot No.：
    Q9Y5P8
  • 基因名：
  • 别名：
    NY REN 8 antibody; NY REN 8 antigen antibody; P2R3B_HUMAN antibody; PP2A B'' subunit PR48 antibody; PP2A subunit B isoform PR48 antibody; PP2A subunit B PR48 isoform antibody; PPP2R3B antibody; PPP2R3L antibody; PPP2R3LY antibody; PR 48 antibody; PR48 antibody; Protein phosphatase 2 (formerly 2A) regulatory subunit B'' beta antibody; Protein phosphatase 2 regulatory subunit B'' beta antibody; Protein phosphatase 2A 48 kDa regulatory subunit antibody; Serine/threonine protein phosphatase 2A 48kDa regulatory subunit B antibody; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein phosphatase 2A regulatory subunit B\'\' subunit beta protein (356-575AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
  • 基因功能参考文献：
    1. PPP2R3B codes for the PR70 protein, a regulatory substrate-recognizing subunit of protein phosphatase 2A. PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing CDC6-chromatin licensing and CDT1 interaction PMID: 27974665
    2. Results show the crystal structure of PR48/PR70, at 2.0 A degrees resolution with two domain elongated structure and two Ca2+ binding EF-hands Scattering data. PMID: 25007185
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 13417

    OMIM: 300339

    KEGG: hsa:28227

    STRING: 9606.ENSP00000375080

    UniGene: Hs.124942