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GREM2 Antibody

  • 货号：
    CSB-PA107590
  • 规格：
    ￥880
  • 图片：
    • Western blot analysis of Mouse kidney, 293T, Mouse lung, antibody was diluted at 1000. Secondary antibody was diluted at 1:20000
    • Immunohistochemical analysis of paraffin-embedded human-small-intestine, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-small-intestine, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200
  • 其他：

产品详情

  • Uniprot No.：
    Q9H772
  • 基因名：
    GREM2
  • 别名：
    BMP antagonist 2 antibody; CKTSF1B2 antibody; Cysteine knot superfamily 1 antibody; Cysteine knot superfamily 1 BMP antagonist 2 antibody; DAN domain family member 3 antibody; DAND 3 antibody; DAND3 antibody; GREM 2 antibody; Grem2 antibody; GREM2_HUMAN antibody; Gremlin 2 antibody; Gremlin 2 cysteine knot superfamily homolog antibody; Gremlin-2 antibody; Gremlin2 antibody; PRDC antibody; Protein related to DAN and cerberus antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 71-120
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.
  • 基因功能参考文献：
    1. TT genotype of the rs4454537 polymorphism protective against the development of osteoporosis PMID: 30014930
    2. Our study confirmed that GREM2 is a candidate gene for tooth agenesis, which mutations can explain, however, only a small fraction of the genetic contribution to the pathogenesis of this anomaly. PMID: 28992378
    3. Data show that the GREMLIN 2 (GREM2) expression during Induced Pluripotent Stem Cell (hiPS) cell cardiac differentiation follows the expression pattern of cardiac-specific genes. PMID: 28125926
    4. The structure of Grem2-GDF5 complex has revealed a number of key findings for DAN-family mediated BMP2 inhibition. PMID: 27524626
    5. This study showed that si-Grem2 increased the BMP-2-induced osteogenic differentiation of hBMSCs via the BMP-2/Smad/Runx2 pathway. PMID: 27335248
    6. The present study shows that the Grem2 heparin/HS and BMP2-binding epitopes are unique and independent, where the Grem2-BMP2 complex exhibits a significant increase in binding affinity toward heparin moieties that appear to be partially independent of the Grem2 heparin/HS-binding epitope. PMID: 28104757
    7. Gremlin 2 inhibits adipocyte differentiation through activation of Wnt/beta-catenin signaling PMID: 26239165
    8. mutations associated with tooth malformations PMID: 26416033
    9. GREM2 variants have been identified in atrial fibrillation cohort studies, demonstrating abnormalities in cardiac excitation - supra ventricular tachycardia and atrial fibrillation. PMID: 25443231
    10. The minor allele of rs4454537 is significantly associated with low bone density at the total hip of southern Chinese people. Our study further suggests GREM2 as a novel susceptibility gene for osteoporosis. PMID: 23902946
    11. Through regulation of bone morphogenetic protein signaling, GREM2 is required for cardiac laterality and atrial differentiation during embryonic development. PMID: 23223679
    12. and that a genetic variant in the FMN2/GREM2 locus influences GREM2 expression in osteoblasts and thereby trabecular number and thickness as well as fracture risk. PMID: 23437003

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  • 相关疾病：
    Tooth agenesis, selective, 9 (STHAG9)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    DAN family
  • 数据库链接：

    HGNC: 17655

    OMIM: 608832

    KEGG: hsa:64388

    STRING: 9606.ENSP00000318650

    UniGene: Hs.98206