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IDH1

Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) and (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO₂. This is a two-step process, which involves oxidation of isocitrate to oxalosuccinate, followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD⁺ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP⁺ as a cofactor instead of NAD⁺. They localize to the cytosol as well as the mitochondrion and peroxisome.

IDH1 Antibodies

IDH1 for Mus musculus (Mouse)

IDH1 for Homo sapiens (Human)

IDH1 Proteins

IDH1 Proteins for Sus scrofa (Pig)

IDH1 Proteins for Rattus norvegicus (Rat)

IDH1 Proteins for Mus musculus (Mouse)

IDH1 Proteins for Homo sapiens (Human)

IDH1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

IDH1 Proteins for Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum)

IDH1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

IDH1 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)

IDH1 Proteins for Pongo abelii (Sumatran orangutan)

IDH1 Proteins for Ovis aries (Sheep)

IDH1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

IDH1 Proteins for Bos taurus (Bovine)