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Idh1 Antibody

  • 货号：
    CSB-PA010989LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA010989LA01MO at dilution of 1:50
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA010989LA01MO at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Idh1 Polyclonal antibody
  • Uniprot No.：
    O88844
  • 基因名：
  • 别名：
    Idh1 antibody; Isocitrate dehydrogenase [NADP] cytoplasmic antibody; IDH antibody; EC 1.1.1.42 antibody; Cytosolic NADP-isocitrate dehydrogenase antibody; IDP antibody; NADP(+)-specific ICDH antibody; Oxalosuccinate decarboxylase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse
  • 免疫原：
    Recombinant Mouse Isocitrate dehydrogenase [NADP] cytoplasmic protein (1-240AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Idh1 Antibody (CSB-PA010989LA01MO)，的标记方式是Non-conjugated。对于Idh1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA010989LB01MO Idh1 Antibody, HRP conjugated ELISA
    FITC CSB-PA010989LC01MO Idh1 Antibody, FITC conjugated
    Biotin CSB-PA010989LD01MO Idh1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Vitamin C treatment induced an IDH1(R132H)-dependent reduction in cell proliferation. PMID: 28663574
    2. IDH1 expression regulates TCA cycle in glioma and affects glioma cell growth.GDH2 promotes growth of IDH1-expressing gliomas. PMID: 29097607
    3. Through the use of a conditional mutant mouse model that confers a less aggressive tumor phenotype, findings provide new insight into the effects of mutant Idh1 on a candidate cell of origin for glioma, mutant Idh1's role in disrupting the microenvironment from which gliomas arise, and mutant Idh1's effect on the course of glioma progression. PMID: 28148827
    4. IDH1 mutations caused down-regulation of leukocyte chemotaxis, resulting in repression of the tumor-associated immune system. PMID: 28465358
    5. Idh1(R132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling gliomagenesis PMID: 27693047
    6. Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1, enzymes involved in the TCA cycle, were elevated. PMID: 27380194
    7. data suggest that mutant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of malignant T cells PMID: 26787889
    8. The results suggest that Idh1 has a physiological function in protecting cells from oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. PMID: 25882048
    9. These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations R132H. PMID: 25849072
    10. MiR-181a regulates lipid metabolism via IDH1 PMID: 25739786
    11. revealed a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity. PMID: 25218477
    12. these data show that mutant IDH or d-2HG causes persistence of chondrocytes, giving rise to rests of growth-plate cells that persist in the bone as enchondromas. PMID: 25730874
    13. WA might exert its chemopreventive activity via inhibiting not only oncogenic activation, but also IDH1 inactivation. PMID: 23107437
    14. Brain-specific Idh1-KI mice show brain hemorrhage accompanied by high D2HG levels but decreased ROS PMID: 22925884
    15. Suggest that decreased IDPc expression renders melanocytes more vulnerable to oxidative stress, and IDPc plays an important antioxidant function in melanocytes. PMID: 22264756
    16. Absence of IDH1 mutations in low-grade gliomas (LGGs) identifies a novel entity of LGGs with distinctive location, infiltrative behavior, specific molecular alterations, and dismal outcome. PMID: 21080178
    17. a possible association between IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia. PMID: 20861910
    18. IDPc would be a major NADPH producer required for fat and cholesterol synthesis. PMID: 15254034
    19. The results suggest that IDPc plays an important protective role in apoptosis of HL-60 cells induced by singlet oxygen. PMID: 17646934
    20. IDPc is expressed differentially along tubules in patterns that may contribute to differences in susceptibility to injury, major enzyme in cytosolic NADPH generation in kidney, downregulated with ischemia-reperfusion PMID: 19106211

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  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Isocitrate and isopropylmalate dehydrogenases family
  • 数据库链接：

    KEGG: mmu:15926

    STRING: 10090.ENSMUSP00000095316

    UniGene: Mm.9925