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CLDN4

CLDN4:作为潜力肿瘤治疗靶标,展示联合用药潜力

Claudin 4( CLDN4 )是一种紧密连接蛋白,是Claudin 家族的一员,Claudin 蛋白均由4个跨膜结构域构成,N端和C端均位于细胞内部,细胞膜外有2个长度不等的环,可以和临近其他同类型的环相接触构成细胞间的紧密连接. 而且CLDN4的结构高度保守,从线虫到人类都十分相似.当Claudin蛋白发生变化时将影响细胞间的通透性进一步引起多种疾病的发生.研究报道CLDN4 在卵巢癌、前列腺癌、乳腺癌、胰腺癌、肠道癌等多种肿瘤中表达上调,并且作为一种癌基因介导癌症的发生。

CUSABIO-哺乳包膜VIPs平台成功开发CLDN4全长跨膜蛋白(4次跨膜),展示了完整生物活性。

热销产品

Recombinant Human Claudin-4(CLDN4)-VLPs (Active) (CSB-MP005506HU)

验证数据

WB验证蛋白特异性

CSB-MP005506HU is detected by Mouse anti-6*His monoclonal antibody.

功能性ELISA验证抗原抗体结合活性

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN4 at 5 μg/ml can bind Anti-CLDN4 recombinant antibody (CSB-RA005506MA1HU), the EC50 is 29.56-50.75 ng/mL

CLDN4 Recombinant Monoclonal Antibody CSB-RA005506MA2HU

验证数据

FC
CSB-RA005506MA2HU FC

Overlay Peak curve showing MCF7 cells stained with CSB-RA005506MA2HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

CLDN4 Antibodies

CLDN4 for Homo sapiens (Human)

CLDN4 Proteins

CLDN4 Proteins for Homo sapiens (Human)

CLDN4 Proteins for Mus musculus (Mouse)

CLDN4 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

CLDN4 Proteins for Bos taurus (Bovine)

CLDN4 ELISA Kit

CLDN4 ELISA Kit for Homo sapiens (Human)