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  4. Recombinant Mouse Claudin-4 (Cldn4)

Recombinant Mouse Claudin-4 (Cldn4)

  • 货号：
    CSB-CF005506MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Cldn4; Cper; Cpetr1; Claudin-4; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-210
  • 氨基酸序列
    MASMGLQVLGISLAVLGWLGIILSCALPMWRVTAFIGSNIVTAQTSWEGLWMNCVVQSTG QMQCKMYDSMLALPQDLQAARALMVISIIVGALGMLLSVVGGKCTNCMEDETVKAKIMIT AGAVFIVASMLIMVPVSWTAHNVIRDFYNPMVASGQKREMGASLYVGWAASGLLLLGGGL LCCSCPPRSNDKPYSAKYSAARSVPASNYV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • 基因功能参考文献：
    1. a Grhl2/Ovol2 network controls Cldn4 and Rab25 expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia PMID: 25788534
    2. Data show that claudin-4 and claudin-7 were observed in hepatocytes of severely damaged mouse and human livers. PMID: 24737165
    3. The claudin-4-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1). PMID: 25157135
    4. Cld4 is selectively expressed on the surface of enteroendocrine cells in the mouse small intestine. PMID: 24603700
    5. Claudin 4 has little effect on normal lung physiology but may function to protect against acute lung injury in mice. PMID: 25106430
    6. The results suggest that progressive hydronephrosis in Cldn4(-/-) mice arises from urinary tract obstruction due to urothelial hyperplasia, and that Cld4 plays an important role in maintaining the homeostatic integrity of normal urothelium. PMID: 23284964
    7. Claudin-3 in the apical-most regions maintains the impermeable tight junctions during lactation, and claudin-4 contributes PMID: 21912970
    8. Claudin-4 overexpression is associated with epigenetic derepression in gastric carcinoma. PMID: 21844869
    9. results suggest that Cld4 is induced by E-protein activity in the later stages of DP cells to increase the efficiency of positive selection, uncovering a hitherto unrecognized function of a Cld family protein PMID: 21325057
    10. data show that claudin-4 interacts with claudin-8 and that their association is required for the anion-selective paracellular pathway in the collecting duct PMID: 20921420
    11. quaternary structure analysis of recombinant protein PMID: 12538885
    12. Experimental obstructive jaundice increases claudin-4 expression in intestinal epithelium, which may be a key factor contributing to the disruption of the mucosal barrier. PMID: 16733860
    13. In the absence of follicle-stimulating hormone receptor signaling, claudin-4 is selectively upregulated in ovarian surface epithelium and tumors in comparison to wild type. PMID: 17217615
    14. Claudin 4 has been found in mouse taste epithelium, with high abundance around the taste pore. A highly specific permeability pattern for paracellular diffusion is apparent, which indicates a peripheral mechanism for taste coding. PMID: 17447253
    15. mouse trophectoderm expressed claudin 4 essential for blastocyst formation in preimplantation mouse embryos PMID: 17980358
    16. Structural constraints for the binding of short peptides to claudin-4 revealed by surface plasmon resonance. PMID: 18782762
    17. We found that claudin-4 contains a sequence which is phosphorylated by atypical PKC (aPKC). These findings suggest that aPKC regulates tight junction formation through the phosphorylation of claudin-4. PMID: 18786529
    18. MUPP1 contributes to the maintenance of a tight epithelium in the medulla of the kidney under hypertonic stress by correctly localizing Cldn4 to the tight junctions PMID: 18840681
    19. changes in alveolar epithelial claudin expression influence paracellular transport, alveolar fluid clearance rates, and susceptibility to pulmonary edema PMID: 19447895

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  • 亚细胞定位：
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Claudin family
  • 组织特异性：
    Expressed primarily in lung and kidney. Present in both cortical and medullar collecting ducts (at protein level).
  • 数据库链接：

    KEGG: mmu:12740

    STRING: 10090.ENSMUSP00000053420

    UniGene: Mm.7339