Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. ACOT8 Antibody

ACOT8 Antibody

  • 货号：
    CSB-PA001170LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA001170LA01HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ACOT8 Polyclonal antibody
  • Uniprot No.：
    O14734
  • 基因名：
    ACOT8
  • 别名：
    ACOT8 antibody; ACTEIII antibody; PTE1 antibody; Acyl-coenzyme A thioesterase 8 antibody; Acyl-CoA thioesterase 8 antibody; EC 3.1.2.1 antibody; EC 3.1.2.11 antibody; EC 3.1.2.2 antibody; EC 3.1.2.3 antibody; EC 3.1.2.5 antibody; Choloyl-coenzyme A thioesterase antibody; EC 3.1.2.27 antibody; HIV-Nef-associated acyl-CoA thioesterase antibody; Peroxisomal acyl-CoA thioesterase 2 antibody; PTE-2 antibody; Peroxisomal acyl-coenzyme A thioester hydrolase 1 antibody; PTE-1 antibody; Peroxisomal long-chain acyl-CoA thioesterase 1 antibody; Thioesterase II antibody; hACTE-III antibody; hACTEIII antibody; hTE antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Acyl-coenzyme A thioesterase 8 protein (1-200AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ACOT8 Antibody (CSB-PA001170LA01HU)，的标记方式是Non-conjugated。对于ACOT8 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA001170LB01HU ACOT8 Antibody, HRP conjugated ELISA
    FITC CSB-PA001170LC01HU ACOT8 Antibody, FITC conjugated
    Biotin CSB-PA001170LD01HU ACOT8 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT). Is also able to hydrolyze CoA esters of dicarboxylic acids. It is involved in the metabolic regulation of peroxisome proliferation.; (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression.
  • 基因功能参考文献：
    1. In summary, lipolytic enzyme ACOT8 is frequently upregulated in HCC clinical specimens. More importantly, ACOT8 silencing leads to inhibition of cell growth in HCC in vitro. PMID: 24788990
    2. Acyl-CoA thioesterase 8 is a specific protein related to nodal metastasis and prognosis of lung adenocarcinoma. PMID: 23540296
    3. ACOT4 and ACOT8 are responsible for the termination of beta-oxidation of dicarboxylic acids of medium-chain length with the concomitant release of the corresponding free acids PMID: 16141203
    4. SREBP2 modulates brain palmitoyl-coa hydrolase gene transcription. PMID: 16335799
    5. An isoform of long-chain acyl-CoA hydrolase may be responsible for the nafamostat hydrolysis in human liver cytosol. PMID: 17624024

    显示更多

    收起更多

  • 亚细胞定位：
    Peroxisome matrix.
  • 蛋白家族：
    C/M/P thioester hydrolase family
  • 组织特异性：
    Detected in a T-cell line (at protein level). Ubiquitous.
  • 数据库链接：

    HGNC: 15919

    OMIM: 608123

    KEGG: hsa:10005

    STRING: 9606.ENSP00000217455

    UniGene: Hs.444776