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ACOT8 Antibody

  • 货号：
    CSB-PA000805
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using ACOT8 Polyclonal Antibody
    • Western Blot analysis of MCF7 PC-12 cells using ACOT8 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O14734
  • 基因名：
    ACOT8
  • 别名：
    ACOT8 antibody; ACTEIII antibody; PTE1 antibody; Acyl-coenzyme A thioesterase 8 antibody; Acyl-CoA thioesterase 8 antibody; EC 3.1.2.1 antibody; EC 3.1.2.11 antibody; EC 3.1.2.2 antibody; EC 3.1.2.3 antibody; EC 3.1.2.5 antibody; Choloyl-coenzyme A thioesterase antibody; EC 3.1.2.27 antibody; HIV-Nef-associated acyl-CoA thioesterase antibody; Peroxisomal acyl-CoA thioesterase 2 antibody; PTE-2 antibody; Peroxisomal acyl-coenzyme A thioester hydrolase 1 antibody; PTE-1 antibody; Peroxisomal long-chain acyl-CoA thioesterase 1 antibody; Thioesterase II antibody; hACTE-III antibody; hACTEIII antibody; hTE antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ACOT8.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT). Is also able to hydrolyze CoA esters of dicarboxylic acids. It is involved in the metabolic regulation of peroxisome proliferation.; (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression.
  • 基因功能参考文献：
    1. In summary, lipolytic enzyme ACOT8 is frequently upregulated in HCC clinical specimens. More importantly, ACOT8 silencing leads to inhibition of cell growth in HCC in vitro. PMID: 24788990
    2. Acyl-CoA thioesterase 8 is a specific protein related to nodal metastasis and prognosis of lung adenocarcinoma. PMID: 23540296
    3. ACOT4 and ACOT8 are responsible for the termination of beta-oxidation of dicarboxylic acids of medium-chain length with the concomitant release of the corresponding free acids PMID: 16141203
    4. SREBP2 modulates brain palmitoyl-coa hydrolase gene transcription. PMID: 16335799
    5. An isoform of long-chain acyl-CoA hydrolase may be responsible for the nafamostat hydrolysis in human liver cytosol. PMID: 17624024

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  • 亚细胞定位：
    Peroxisome matrix.
  • 蛋白家族：
    C/M/P thioester hydrolase family
  • 组织特异性：
    Detected in a T-cell line (at protein level). Ubiquitous.
  • 数据库链接：

    HGNC: 15919

    OMIM: 608123

    KEGG: hsa:10005

    STRING: 9606.ENSP00000217455

    UniGene: Hs.444776