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生长因子

细胞因子是指在组织培养中,除了氨基酸、维生素、葡萄糖以及无机盐等正常成分之外,可以代替培养基血清高分子物质从而促进细胞生长、分化、存活、炎症反应和组织修复的物质。是具有刺激细胞生长活性的细胞因子,通常是蛋白质或类固醇激素。

生长因子有很多种类,如血小板类生长因子(血小板来源生长因子PDGF、骨肉瘤来源生长因子ODGF)、表皮生长因子类(表皮生长因子EGF、转化生长因子TGFα和TGFβ)、成纤维细胞生长因子(αFGF、βFGF)、类胰岛素生长因子(IGF-Ⅰ、IGF-Ⅱ)、神经生长因子(NGF)、白细胞介素类生长因子(IL-1、IL-1、IL-3等)、红细胞生长素(EPO)、集落刺激因子(CSF)等。

j9九游会登录入口首页生物生长因子蛋白几乎涵盖了所有细胞因子及其受体,这里展示了部分生长因子蛋白产品图:

产品名称 货号 规格
Recombinant Human Bone morphogenetic protein 2 (BMP2) (Active) CSB-AP003991HU 1mg(1mg*1 or 500ug*2)/500μg/50μg/10μg
Recombinant Human Leukemia inhibitory factor (LIF) (Active) CSB-AP004001HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Inhibin beta A chain (INHBA) (Active) CSB-AP004011HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Fibroblast growth factor 12 (FGF12) (Active) CSB-AP004021HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Fibroblast growth factor 8 (FGF8) (Active) CSB-AP004031HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Fibroblast growth factor 8 (FGF8), partial (Active) CSB-AP004041HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Transforming growth factor beta-3 (TGFB3),Partial (Active) CSB-AP004051HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Mouse Fibroblast growth factor 2 (Fgf2) (Active) CSB-AP004061MO 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Mouse Kit ligand (Kitlg), partial (Active) CSB-AP004071MO 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Mouse Beta-nerve growth factor (Ngf), partial (Active) CSB-AP004081MO 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Mouse Pro-epidermal growth factor (Egf), partial (Active) CSB-AP004091MO 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Mouse Beta-nerve growth factor (Ngf) (Active) CSB-AP004101MO 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Mouse Transforming growth factor beta-1 proprotein (Tgfb1), partial (Active) CSB-AP004111MO 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Mouse Fibroblast growth factor 17 (Fgf17) (Active) CSB-AP004121MO 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Mouse Fibroblast growth factor 9 (Fgf9) (Active) CSB-AP004131MO 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Mouse Platelet-derived growth factor subunit B (Pdgfb) (Active) CSB-AP004141MO 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Mouse Fibroblast growth factor 1 (Fgf1) (Active) CSB-AP004151MO 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Rat Fibroblast growth factor 2 (Fgf2), partial (Active) CSB-AP004171RA 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Basic Fibroblast Growth Factor (FGF2), partial (Active) (GMP) CSB-AP005911HU 1mg(1mg*1 or 500ug*2)/100μg/5μg
Recombinant Human Insulin-like growth factor I (IGF1) (Active) (GMP) CSB-AP005921HU 1mg(1mg*1 or 500ug*2)/100μg/5μg

如前所述,生长因子涉及许多家族,包括成纤维细胞生长因子(FGFs),转化生长因子(TGFs),血管内皮生长因子(VEGFs),血小板衍生生长因子(PDGFs)和神经营养因子等。这里简单的介绍了几种生长因子及对应受体。

成纤维细胞生长因子(FGFs),该基因突变与多种疾病相关,例如心血管疾病、骨关节炎、肝细胞癌、椎间盘稳态和低磷血症。FGF家族包括FGF-1至FGF-23的22个成员,FGF-15只存在于小鼠中。除四个成员(FGF11-FGF14)外,其他所有的FGF都能与FGF受体结合。

转化生长因子(也称为肿瘤生长因子或TGF),指两类多肽生长因子,转化生长因子α(TGFα)和转化生长因子β(TGFβ)。 TGFα和TGFβ是自分泌生长因子,在正常组织中,分别是有效的启动子和细胞生长抑制剂。TGFα可参与肝癌发生和发病过程。TGFβ一般是通过与TGFβ受体结合后起作用,有资料表明,在结肠直肠腺瘤中,存在人体中的三种TGFβ受体(TGFβ1、TGFβ2和TGFβ3)的表达均上调,而且与晚期肿瘤特征直接相关。

血管内皮生长因子,也称为血管通透因子VEGF,是由刺激血管形成的细胞和血管内皮细胞的促分裂原产生的生长因子亚家族。血管生长因子家族中有五个成员,包括VEGF-A,VEGF-B,VEGF-C,VEGF-D和胎盘生长因子(PlGF)。