Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Mouse Interferon alpha-inducible protein 27-like protein 2A (Ifi27l2a)

Recombinant Mouse Interferon alpha-inducible protein 27-like protein 2A (Ifi27l2a)

In Stock
  • 货号：
    CSB-CF840289MO
  • 规格：
    ￥9720
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Ifi27l2a
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    in vitro E.coli expression system
  • 分子量：
    7.3 kDa
  • 表达区域：
    25-90aa
  • 氨基酸序列
    AMGFTGTGIAAASIAAKMMSAAAIANGGGVAAGSLVATLQSAGVLGLSTSTNAILGAAGAAVGALL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors. Through the regulation of NR4A1 transcriptional activity, may play a role in the vascular response to injury.
  • 基因功能参考文献：
    1. Collectively, these findings suggest that Ifi27l2a has an antiviral phenotype in subsets of cells and that at least some interferon-stimulated genes have specific inhibitory functions in restricted tissues in West Nile virus infection. PMID: 26699642
    2. up-regulation of Ifi27l2a in infected lungs is mainly due to the infiltration of macrophages and lymphocytes. Most surprisingly, deletion of Ifi27l2a in mouse knock-out lines did not result in increased susceptibility to infections PMID: 25184786
    3. modulator of innate immune responses in sepsis models PMID: 23747037
    4. Identify a feedback loop activated by interferons via interferon stimulated gene 12 that inhibits the vasculoprotective functions of NR4A1 nuclear receptors. PMID: 22427340
    5. induced by Sindbis virus encephalitis to greater levels in brains of weanling mice than neonatal mice and significantly delayed death in the neonatal mice (interferon- inducible protective protein, ISG12). PMID: 12388728
    6. ISG12b is an additional candidate for a adipocytokine induced to express in adipose tissue by interferon PMID: 17704618
    7. Mitochondrial-localized ISG12b1 protein inhibits adipocyte differentiation and mitochondrial biogenesis and function. PMID: 18948406

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    IFI6/IFI27 family
  • 数据库链接：

    KEGG: mmu:76933

    STRING: 10090.ENSMUSP00000054698

    UniGene: Mm.271275