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  4. Recombinant Mouse Interferon alpha-inducible protein 27-like protein 2A (Ifi27l2a), partial

Recombinant Mouse Interferon alpha-inducible protein 27-like protein 2A (Ifi27l2a), partial

  • 中文名称：
    小鼠Ifi27l2a重组蛋白
  • 货号：
    CSB-YP840289MO1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ifi27l2a重组蛋白
  • 货号：
    CSB-EP840289MO1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ifi27l2a重组蛋白
  • 货号：
    CSB-EP840289MO1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ifi27l2a重组蛋白
  • 货号：
    CSB-BP840289MO1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ifi27l2a重组蛋白
  • 货号：
    CSB-MP840289MO1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ifi27l2a
  • Uniprot No.：
  • 别名：
    Ifi27l2a; Ifi27; Isg12; Interferon alpha-inducible protein 27-like protein 2A; Interferon-stimulated gene 12 protein; ISG12
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors. Through the regulation of NR4A1 transcriptional activity, may play a role in the vascular response to injury.
  • 基因功能参考文献：
    1. Collectively, these findings suggest that Ifi27l2a has an antiviral phenotype in subsets of cells and that at least some interferon-stimulated genes have specific inhibitory functions in restricted tissues in West Nile virus infection. PMID: 26699642
    2. up-regulation of Ifi27l2a in infected lungs is mainly due to the infiltration of macrophages and lymphocytes. Most surprisingly, deletion of Ifi27l2a in mouse knock-out lines did not result in increased susceptibility to infections PMID: 25184786
    3. modulator of innate immune responses in sepsis models PMID: 23747037
    4. Identify a feedback loop activated by interferons via interferon stimulated gene 12 that inhibits the vasculoprotective functions of NR4A1 nuclear receptors. PMID: 22427340
    5. induced by Sindbis virus encephalitis to greater levels in brains of weanling mice than neonatal mice and significantly delayed death in the neonatal mice (interferon- inducible protective protein, ISG12). PMID: 12388728
    6. ISG12b is an additional candidate for a adipocytokine induced to express in adipose tissue by interferon PMID: 17704618
    7. Mitochondrial-localized ISG12b1 protein inhibits adipocyte differentiation and mitochondrial biogenesis and function. PMID: 18948406

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  • 亚细胞定位：
    Nucleus inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    IFI6/IFI27 family
  • 数据库链接：

    KEGG: mmu:76933

    STRING: 10090.ENSMUSP00000054698

    UniGene: Mm.271275