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  4. Recombinant Mouse Cystatin-C (Cst3)

Recombinant Mouse Cystatin-C (Cst3)

In Stock
  • 货号：
    CSB-EP006091MO
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cst3Cystatin-C; Cystatin-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    20.4 kDa
  • 表达区域：
    21-140aa
  • 氨基酸序列
    ATPKQGPRMLGAPEEADANEEGVRRALDFAVSEYNKGSNDAYHSRAIQVVRARKQLVAGVNYFLDVEMGRTTCTKSQTNLTDCPFHDQPHLMRKALCSFQIYSVPWKGTHSLTKFSCKNA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer，50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
  • 基因功能参考文献：
    1. CysC plays an important regulatory role in combating cell death via the autophagic pathway in atherosclerosis. PMID: 27079462
    2. Data (including data from studies in mutant mice) suggest that up-regulation of Cst3, as observed in plasma of mice with type 2 diabetes, down-regulates insulin signaling and promotes endoplasmic reticulum stress in hepatocytes but not in myotubes. PMID: 26592151
    3. Cystatin C is a potential pathogenic signal triggering neurodegeneration in multiple system atrophy. PMID: 24405769
    4. The neuroprotective activity of CysC against Amyotrophic lateral sclerosis-linked mutant Cu/Zn-superoxide dismutase (SOD1)-mediated toxicity. PMID: 25356866
    5. an important role for macrophages, DC, and ROS in diseases associated with the protease inhibitory activity or amyloidogenic properties of cystatin C. PMID: 24570004
    6. APP expression stimulates NSPC proliferation; this effect is mediated via an increase in cystatin C secretion PMID: 23671283
    7. Cystatin C, a protein targeted to the classical secretory pathway by its signal peptide sequence, is secreted by primary neurons in at least 9 different cystatin C glycoforms associated with exosomes. PMID: 19773092
    8. The lack of cystatin C enhances Collagen-induced arthritis and primarily affects in vivo priming of the immune system PMID: 21443774
    9. Inflammation causes downregulation of cystatin C expression in dendritic cells and reduces serum CstC levels. PMID: 21300820
    10. Data show that the absence of cystatin C reduced epithelial cell apoptosis but increased proliferation in skin. PMID: 21085595
    11. Data show that cystatin C effectively rescues cystatin B loss-of-function mutation, facilitating the reversal of pathophysiological changes and suggesting a novel therapeutic intervention for patients with neurodegenerative disorders. PMID: 20889561
    12. CysC plays a protective role under conditions of neuronal challenge by inducing autophagy via mTOR inhibition PMID: 20352108
    13. Oxidants induce elevated cystatin C production from cardiac myocytes. Cystatin C plays a role in cardiac extracellular matrix remodelling. PMID: 20489058
    14. Data show that cystatin c (CystC) contributes to experimental abdominal aortic aneurysms (AAA) pathogenesis and that lack of CystC favors inflammation in AAA lesions induced in atherosclerotic mice. PMID: 20472891
    15. The embryo's cystatin C and F expression functions as a protective mechanism against the maternal proteinase cathepsin S. PMID: 20093401
    16. Cystatin C through this effect can act as an immunomodulatory molecule. PMID: 19446036
    17. expressed in decidual cultures and the expression is controlled in part by TGF-beta(1) and EGF signaling PMID: 11803549
    18. spatiotemporal up-regulation of cystatin C in the hippocampus is induced by entorhinal deafferentation (perforant path transections) PMID: 12044447
    19. Cystatin C is neither necessary nor sufficient to control expression of major histocompatibility type II complexes and antigen presentation in dendritic cells. PMID: 14607896
    20. In vivo overexpression of human cystatin C does not affect amyloid-beta levels in mice that do not deposit amyloid-beta. PMID: 14742906
    21. Data indicate that cystatin C is involved in astrocyte differentiation during mouse brain development. PMID: 15509901
    22. leukocyte-specific expression of cystatin C is actively involved in matrix remodelling associated with atherosclerosis plaque regression. PMID: 15823274
    23. the protective role of cystatin C in atherosclerosis is dependent primarily on its expression in nonhematopoietic cell types PMID: 16051881
    24. PKB activity is a critical downstream component of PDK-1 in mediating translation of cystatin C, RANKL, and Rab11a PMID: 16166629
    25. These data demonstrate that cystatin C has a role in neuronal death and neurogenesis during SE-induced network reorganization. PMID: 16242633
    26. Validity of cystatin C for generating neural stem cells from embryo stem cells in vitro. PMID: 16595632
    27. We propose that in MS, remyelination may be impaired by increasing activity of cathepsins inadequately controlled by cystatin C. PMID: 17086443
    28. Finally, in vivo studies using kidney-specific megalin knockout mice provide evidence that megalin mediates proximal tubular uptake of cystatin C. We conclude that megalin is an endocytic receptor of cystatin C in PTC. PMID: 17462596
    29. These results suggest that CysC affects the BMP signaling cascades in osteoblastic cells and then promotes osteoblast differentiation, mineralization, and bone formation. PMID: 17592728
    30. Plasminogen activator inhibitor-2, but not cystatin C, inhibits the prometastatic activity of tissue inhibitor of metalloproteinases-1 in the liver.( PMID: 18681831
    31. CysC regulates soluble Abeta and Abeta-associated neuronal deficits through inhibiting CatB-induced Abeta degradation. PMID: 18957217

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Cystatin family
  • 数据库链接：

    KEGG: mmu:13010

    STRING: 10090.ENSMUSP00000028938

    UniGene: Mm.4263