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  4. Recombinant Human papillomavirus type 18 Protein E7 (E7)

Recombinant Human papillomavirus type 18 Protein E7 (E7)

In Stock
  • 货号：
    CSB-YP361948HMN
  • 规格：
    ￥1500
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    E7; Protein E7
  • 种属：
    Human papillomavirus type 18
  • 蛋白长度：
    Full Length
  • 来源：
    Yeast
  • 分子量：
    14.0 kDa
  • 表达区域：
    1-105aa
  • 氨基酸序列
    MHGPKATLQDIVLHLEPQNEIPVDLLCHEQLSDSEEENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIKLVVESSADDLRAFQQLFLNTLSFVCPWCASQQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：
        乳头瘤病毒（HPV）是一组常见的病毒，其中HPV-18型是引发宫颈癌等癌症的主要病毒株之一。人乳头瘤病毒18型蛋白E7（E7）是HPV感染中的一个关键蛋白，通过干扰宿主细胞的调控机制，参与细胞转型和癌症的发生。
        j9九游会登录入口首页生物的重组人HPV18型E7蛋白是通过酵母表达系统表达的全长蛋白，包括E7蛋白的完整序列。该产品可用于体外实验、蛋白结合研究和功能性实验。通过研究E7蛋白，可以深入了解HPV感染引发的宫颈癌等癌症的分子机制。E7蛋白与宿主细胞中的关键调控分子相互作用，影响细胞周期、凋亡等关键生物学过程。
  • Datasheet & COA：
    Please contact us to get it.

产品评价

问答及客户评论

■ 常见问题解答
Q:

Can you please provide the concentration of CSB-EP361948HMN; Recombinant Human papillomavirus type 18 Protein E7 (E7) to me?

A:
Thanks for your inquiry. According the the record, this protein is provdied as lyophilized form.
Lyophilized from a 0.2 μm filtered 10 mM Tris-HCl, 1 mM EDTA, pH 8.0.
The volume before lyophilization is 200ul/vial.

靶点详情

  • 功能：
    Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
  • 亚细胞定位：
    Host cytoplasm. Host nucleus.
  • 蛋白家族：
    Papillomaviridae E7 protein family