Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 重组抗体
  4. TBR1 Recombinant Monoclonal Antibody

TBR1 Recombinant Monoclonal Antibody

  • 货号：
    CSB-RA618090A0HU
  • 规格：
    ￥1320
  • 其他：

产品详情

  • 产品描述：

    The recombinant TBR1 antibody is a monoclonal antibody made in vitro using the TBR1 antibody genes that are typically expressed from a plasmid in a stable mammalian cell line. The genes coding for the TBR1 antibody will ultimately assemble into a fully functional antibody after translation. The synthesized antibody is the recombinant antibody against TBR1. It underwent purification using affinity-chromatography. This recombinant TBR1 antibody is suitable for use in the ELISA to detect the TBR1 protein from Human.

    TBR1 is a neuron-specific T-box transcription factor that regulates the regional and laminar identity of the developing brain's neocortical regions, including layer 6. TBR1 is abundantly expressed in the deep layers of the cortex, where it takes part in the differentiation of subsets of projection neurons. In addition to controlling axonal projection, TBR1 also plays an essential role in neuronal activation. The TBR1 gene binds to the promoter of Grin2b and regulates Grin2b expression in response to neuronal activation. TBR1 has been linked to a variety of brain problems, including autism spectrum disorders (ASDs) and intellectual disability, due to its importance in both brain and cortical development.

  • Uniprot No.：
    Q16650
  • 基因名：
    TBR1
  • 别名：
    T box brain 1 antibody; T box brain protein 1 antibody; T brain 1 protein antibody; T-box brain protein 1 antibody; T-brain-1 antibody; TBR 1 antibody; TBR-1 antibody; Tbr1 antibody; TBR1_HUMAN antibody; TES 56 antibody; TES-56 antibody
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human TBR1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    2E10
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection. As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons.
  • 基因功能参考文献：
    1. TBR1 homodimerizes; it interacts with FOXP2, a transcription factor implicated in speech/language disorders, and this interaction is disrupted by pathogenic mutations affecting either protein PMID: 25232744
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Brain.
  • 数据库链接：

    HGNC: 11590

    OMIM: 604616

    KEGG: hsa:10716

    STRING: 9606.ENSP00000374205

    UniGene: Hs.210862