Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 重组抗体
  4. Histone H2A type 1-B/E Recombinant Monoclonal Antibody

Histone H2A type 1-B/E Recombinant Monoclonal Antibody

  • 货号：
    CSB-RA010385A0HU
  • 规格：
    ￥1320
  • 图片：
    • Western Blot
      Positive WB detected in HepG2 whole cell lysate
      All lanes Histone H2A type 1-B/E antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 13 KDa
      Observed band size: 13 KDa
    • Immunofluorescence staining of Hela cells with CSB-RA010385A0HU at 1:168,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
  • 其他：

产品详情

  • 产品描述：

    The recombinant monoclonal antibody against histone H2A type 1-B/E was prepared by transfecting the vector containing the DNA for the histone H2A type 1-B/Emonoclonal antibody into the cell lines for in vitro production. The product was purified using affinity chromatography to obtain the histone H2A type 1-B/E recombinant antibody. This antibody is a rabbit IgG and recognizes human histone H2A type 1-B/E. It has been tested and approved for use in ELISA, WB, and IF.

    Histone proteins are required for the shift between active and inactive chromatin states, both structurally and functionally. Histones have evolved to play a variety of roles in gene regulation and epigenetic silencing, despite their high conservation due to restrictions to maintain the overall shape of the nucleosomal octameric core. DMA replication, transcription, repair, and recombination are influenced by histone variations, post-translational modifications, and interactions with chromatin remodeling complexes.

  • Uniprot No.：
    P04908
  • 基因名：
    HIST1H2AB
  • 别名：
    H2a 615 antibody; H2A antibody; H2A GL101 antibody; H2A histone family member A antibody; H2A.1 antibody; H2A.2 antibody; H2A/a antibody; H2A/m antibody; H2A/O antibody; H2A/q antibody; H2A1B_HUMAN antibody; H2AFA antibody; H2AFE antibody; H2AFL antibody; H2AFM antibody; H2AFO antibody; H2AFQ antibody; HIST1H2AE antibody; HIST1H2AJ antibody; HIST2H2AA antibody; HIST2H2AA3 antibody; HIST2H2AB antibody; HIST2H2AC antibody; Histone 1 H2ae antibody; Histone 2 H2aa3 antibody; Histone 2 H2ab antibody; Histone 2 H2ac antibody; Histone H2A type 1 B antibody; Histone H2A type 1 C antibody; Histone H2A type 1 E antibody; Histone H2A type 1 J antibody; Histone H2A type 1-B/E antibody; Histone H2A.2 antibody; Histone H2A/a antibody; Histone H2A/m antibody; MGC74460 antibody
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    1H12
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:30-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Histone H2A family
  • 数据库链接：

    HGNC: 4734

    OMIM: 602786

    KEGG: hsa:3012

    STRING: 9606.ENSP00000303373

    UniGene: Hs.121017