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tal1 Antibody

  • 货号：
    CSB-PA20969A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Zebrafish tissue 20μg, 10μg
      All lanes: tal1 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 36, 23 kDa
      Observed band size: 36 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) tal1 Polyclonal antibody
  • Uniprot No.：
    O93507
  • 基因名：
    tal1
  • 别名：
    tal1 antibody; scl antibody; tal-1 antibody; si:ch211-135j1.3 antibody; T-cell acute lymphocytic leukemia protein 1 homolog antibody; TAL-1 antibody; Stem cell protein antibody; zSCL antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Zebrafish
  • 免疫原：
    Recombinant Zebrafish T-cell acute lymphocytic leukemia protein 1 homolog protein (1-324AA)
  • 免疫原种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 标记方式：
    Non-conjugated

    本页面中的产品，tal1 Antibody (CSB-PA20969A0Rb)，的标记方式是Non-conjugated。对于tal1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA20969B0Rb tal1 Antibody, HRP conjugated ELISA
    FITC CSB-PA20969C0Rb tal1 Antibody, FITC conjugated
    Biotin CSB-PA20969D0Rb tal1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the regulation of primitive erythroid differentiation and definitive hemopoietic stem cell specification, most likely due to differences in expression levels. Specification of definitive hemopoietic stem cells requires isoform beta. DNA binding is required for erythroid maturation, but not for its other hemopoietic functions. Endothelial roles include development of the dorsal aorta, the site of definitive hemopoiesis in the embryo. Required for angiogenesis but not angioblast specification. Has an additional role in endocardium formation during heart development. May play a role in central nervous system development.
  • 基因功能参考文献：
    1. The latter data suggest that Stil play a role in retina cell proliferation through the Shh signal transduction pathway. PMID: 24469449
    2. Tal1 has distinct roles in regulating the formation of endocardial intercellular junctions. PMID: 24075907
    3. Data suggest that a defined hemogenic endothelial population preset by scl-beta supports the deterministic emergence of HSCs, and unravel the cellular mechanisms by which scl isoforms regulate HSC development. PMID: 24046317
    4. Our studies establish a new connection between RA and scl during development that may participate in stem cell self-renewal and hematopoietic differentiation PMID: 20410509
    5. Ets1-related protein plays a critical role in the initiation of definitive hematopoiesis by controlling the expression of 2 stem cell leukemia (scl) isoforms (scl-alpha and scl-beta) in angioblasts. PMID: 20185582
    6. in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2-induced haemangioblasts differentiate into endothelial cells PMID: 14602685
    7. Zebrafish scl has a role in hematopoietic and endothelial development, downstream of hemangioblast development. PMID: 15617691
    8. scl is especially critical for the development of arteries where adult hematopoietic stem cells emerge, implicating scl in the formation of hemogenic endothelium PMID: 15644413
    9. Scl participates in multiple processes requiring different levels and functions PMID: 16210319
    10. While scl-alpha and -beta are redundant for the initiation of primitive hematopoiesis, these two isoforms exert distinct functions in the regulation of primitive erythroid differentiation and definitive hematopoietic stem cell specification. PMID: 17472439
    11. In germline-transgenic zebrafish generated by inserting GFP into the first coding exon of scl, GFP expression completely recapitulates the endogenous expression of scl in blood, endothelium and CNS. PMID: 17559829
    12. Scl/Tal1 is an indispensable component of the molecular hierarchy that controls endocardium morphogenesis. PMID: 17722983
    13. These results demonstrate that scl is an important mediator of the ability of AML1-ETO to reprogram hematopoietic cell fate decisions, suggesting that scl may be an important contributor to AML1-ETO-associated leukemia. PMID: 18156164

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in hemopoietic and endothelial lineages. Isoform beta emerges first, expressing in the entire anterior and posterior lateral mesoderm (ALM and PLM respectively), and in the ventral wall of the dorsal aorta, where definitive hemopoiesis begins. I
  • 数据库链接：

    KEGG: dre:30766

    STRING: 7955.ENSDARP00000077498

    UniGene: Dr.75812