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hly Antibody

  • 货号：
    CSB-PA639324HA01FLF
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Staphylococcus aureus hly Polyclonal antibody
  • Uniprot No.：
    Q2G1X0
  • 基因名：
    hly
  • 别名：
    hly antibody; hla antibody; SAOUHSC_01121Alpha-hemolysin antibody; Alpha-HL antibody; Alpha-toxin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Staphylococcus aureus
  • 免疫原：
    Recombinant Staphylococcus aureus Alpha-hemolysin protein (27-319AA)
  • 免疫原种属：
    Staphylococcus aureus
  • 标记方式：
    Non-conjugated

    本页面中的产品，hly Antibody (CSB-PA639324HA01FLF)，的标记方式是Non-conjugated。对于hly Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA639324HB01FLF hly Antibody, HRP conjugated ELISA
    FITC CSB-PA639324HC01FLF hly Antibody, FITC conjugated
    Biotin CSB-PA639324HD01FLF hly Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity.
  • 基因功能参考文献：
    1. We now show that ADAM10 is critical for alpha-hemolysin-mediated activation of the NLRP3 inflammasome in human monocytes as siRNA knockdown or chemical blockade of ADAM10-alpha-hemolysin interaction leads to diminished inflammasome activation and cell death by reducing the available ADAM10 on the cell surface. PMID: 27043625
    2. Staphylococcus aureus hemolysin A disrupts cell-matrix adhesions in human airway epithelial cells. PMID: 24918472
    3. Succeeded in preparing crystals of the heptameric form of alpha-hemolysin without any detergent but with 2-methyl-2,4-pentanediol (MPD), and determined its structure. PMID: 21280135
    4. Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells PMID: 19826485
    5. The wide vestibule leading into the alpha-hemolysin pore helps to orient negatively charged synthetic alpha-helical peptides for translocation. PMID: 16866363

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Aerolysin family
  • 数据库链接：

    KEGG: sao:SAOUHSC_01121

    STRING: 93061.SAOUHSC_01121