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ZG16 Antibody

  • 货号：
    CSB-PA026478GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O60844
  • 基因名：
    ZG16
  • 别名：
    hZG16 antibody; Jacalin like lectin domain containing antibody; JCLN antibody; JCLN1 antibody; Secretory lectin ZG16 antibody; Zg16 antibody; ZG16_HUMAN antibody; ZG16A antibody; Zymogen granule membrane protein 16 antibody; Zymogen granule protein 16 antibody; Zymogen granule protein 16 homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ZG16
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.
  • 基因功能参考文献：
    1. our study demonstrated that ZG16 expression was sequentially reduced from normal, adenoma, to carcinoma. Association with multiple clinicopathological features indicates that ZG16 may play an important role in cancer initiation and progression. ZG16 may serve as a potential biomarker for diagnosis and prognosis of colorectal cancer PMID: 29661177
    2. Data show that an upstream regulator of zymogen granule protein 16 (ZG16), miR-196a, which was significantly overexpressed in colorectal cancer (CRC) and promotes cell growth and stemness. PMID: 27880730
    3. Pathogen-related glycan microarray analysis identified phosphatidylinositol mono- and di-mannosides (PIM1 and PIM2) as novel ligand candidates of ZG16p. PMID: 25919894
    4. Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system. PMID: 21893569
    5. the sugar-binding site and the adjacent basic patch of ZG16p and ZG16b cooperatively form a functional glycosaminoglycan-binding site. PMID: 21110947
    6. hZG16 was markedly down-regulated in hepatocellular carcinoma (HCC) as indicated by RT-PCR. PMID: 17307141

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix. Zymogen granule lumen. Golgi apparatus lumen.
  • 蛋白家族：
    Jacalin lectin family
  • 组织特异性：
    Highly expressed in liver. Detected at lower levels in colon, ileum and jejunum.
  • 数据库链接：

    HGNC: 30961

    KEGG: hsa:653808

    STRING: 9606.ENSP00000383563

    UniGene: Hs.632195