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  4. Recombinant Human Zymogen granule membrane protein 16 (ZG16)

Recombinant Human Zymogen granule membrane protein 16 (ZG16)

  • 货号：
    CSB-YP528909HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP528909HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP528909HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP528909HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP528909HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZG16
  • Uniprot No.：
  • 别名：
    hZG16; Jacalin like lectin domain containing; JCLN; JCLN1; Secretory lectin ZG16; Zg16; ZG16_HUMAN; ZG16A; Zymogen granule membrane protein 16; Zymogen granule protein 16; Zymogen granule protein 16 homolog
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    17-167
  • 氨基酸序列
    NAIQARSSSYSGEYGGGGGKRFSHSGNQLDGPITALRVRVNTYYIVGLQVRYGKVWSDYVGGRNGDLEEIFLHPGESVIQVSGKYKWYLKKLVFVTDKGRYLSFGKDSGTSFNAVPLHPNTVLRFISGRSGSLIDAIGLHWDVYPSSCSRC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.
  • 基因功能参考文献：
    1. our study demonstrated that ZG16 expression was sequentially reduced from normal, adenoma, to carcinoma. Association with multiple clinicopathological features indicates that ZG16 may play an important role in cancer initiation and progression. ZG16 may serve as a potential biomarker for diagnosis and prognosis of colorectal cancer PMID: 29661177
    2. Data show that an upstream regulator of zymogen granule protein 16 (ZG16), miR-196a, which was significantly overexpressed in colorectal cancer (CRC) and promotes cell growth and stemness. PMID: 27880730
    3. Pathogen-related glycan microarray analysis identified phosphatidylinositol mono- and di-mannosides (PIM1 and PIM2) as novel ligand candidates of ZG16p. PMID: 25919894
    4. Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system. PMID: 21893569
    5. the sugar-binding site and the adjacent basic patch of ZG16p and ZG16b cooperatively form a functional glycosaminoglycan-binding site. PMID: 21110947
    6. hZG16 was markedly down-regulated in hepatocellular carcinoma (HCC) as indicated by RT-PCR. PMID: 17307141

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix. Zymogen granule lumen. Golgi apparatus lumen.
  • 蛋白家族：
    Jacalin lectin family
  • 组织特异性：
    Highly expressed in liver. Detected at lower levels in colon, ileum and jejunum.
  • 数据库链接：

    HGNC: 30961

    KEGG: hsa:653808

    STRING: 9606.ENSP00000383563

    UniGene: Hs.632195