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YY1AP1 Antibody

  • 货号：
    CSB-PA884488LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA884488LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA884488LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Western Blot
      Positive WB detected in: SH-SY5Y whole cell lysate, Hela whole cell lysate, K562 whole cell lysate, Jurkat whole cell lysate, HL60 whole cell lysate, 293 whole cell lysate
      All lanes: YY1AP1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 88, 84, 82, 81, 76, 80, 51, 96, 98 kDa
      Observed band size: 88 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) YY1AP1 Polyclonal antibody
  • Uniprot No.：
    Q9H869
  • 基因名：
    YY1AP1
  • 别名：
    FLJ10875 antibody; FLJ13914 antibody; GRNG antibody; HCCA1 antibody; HCCA2 antibody; Hepatocellular carcinoma susceptibility protein antibody; Hepatocellular carcinoma-associated protein 2 antibody; OTTHUMP00000033475 antibody; OTTHUMP00000033476 antibody; OTTHUMP00000200831 antibody; OTTHUMP00000200832 antibody; OTTHUMP00000200833 antibody; OTTHUMP00000200836 antibody; YAP antibody; YY1-associated protein 1 antibody; YY1AP antibody; YY1AP1 antibody; YYAP1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human YY1-associated protein 1 protein (335-466AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，YY1AP1 Antibody (CSB-PA884488LA01HU)，的标记方式是Non-conjugated。对于YY1AP1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA884488LB01HU YY1AP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA884488LC01HU YY1AP1 Antibody, FITC conjugated
    Biotin CSB-PA884488LD01HU YY1AP1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation.
  • 基因功能参考文献：
    1. Data indicate WW-binding protein 2 (WBP2) as an important co-factor of YY1 associated protein 1 (YAP) that enhances YAP/TEAD-mediated gene transcription. PMID: 28332498
    2. Loss-of-Function Mutations in YY1AP1 Lead to Grange Syndrome and a Fibromuscular Dysplasia-Like Vascular Disease. PMID: 27939641
    3. YY1AP1 may serve as a key molecular target for EpCAM(+) AFP(+) HCC subtype PMID: 25597408
    4. human liver cancer associated gene PMID: 11856496
    5. YY1AP is a novel co-activator of YY1 PMID: 14744866
    6. HCCA2 may play a novel role in cell cycle regulation. PMID: 17541814

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  • 相关疾病：
    Grange syndrome (GRNG)
  • 亚细胞定位：
    Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus.
  • 组织特异性：
    Ubiquitous. Detected in small intestine, skeletal muscle, lung, pancreas, brain, stomach, spleen, colon and heart. Detected at very low levels in healthy liver. Highly expressed in most liver carcinomas.
  • 数据库链接：

    HGNC: 30935

    OMIM: 602531

    KEGG: hsa:55249

    STRING: 9606.ENSP00000357323

    UniGene: Hs.584927