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  4. Recombinant Human YY1-associated protein 1 (YY1AP1)

Recombinant Human YY1-associated protein 1 (YY1AP1)

  • 中文名称：
    人YY1AP1重组蛋白
  • 货号：
    CSB-YP884488HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人YY1AP1重组蛋白
  • 货号：
    CSB-EP884488HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人YY1AP1重组蛋白
  • 货号：
    CSB-EP884488HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人YY1AP1重组蛋白
  • 货号：
    CSB-BP884488HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人YY1AP1重组蛋白
  • 货号：
    CSB-MP884488HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    YY1AP1
  • Uniprot No.：
  • 别名：
    FLJ10875; FLJ13914; GRNG; HCCA1; HCCA2; Hepatocellular carcinoma susceptibility protein; Hepatocellular carcinoma-associated protein 2; OTTHUMP00000033475; OTTHUMP00000033476; OTTHUMP00000200831; OTTHUMP00000200832; OTTHUMP00000200833; OTTHUMP00000200836; YAP; YY1-associated protein 1; YY1AP; YY1AP1; YYAP1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-796
  • 氨基酸序列
    MEEEASRSAA ATNPGSRLTR WPPPDKREGS AVDPGKRRSL AATPSSSLPC TLIALGLRHE KEANELMEDL FETFQDEMGF SNMEDDGPEE EERVAEPQAN FNTPQALRFE ELLANLLNEQ HQIAKELFEQ LKMKKPSAKQ QKEVEKVKPQ CKEVHQTLIL DPAQRKRLQQ QMQQHVQLLT QIHLLATCNP NLNPEASSTR ICLKELGTFA QSSIALHHQY NPKFQTLFQP CNLMGAMQLI EDFSTHVSID CSPHKTVKKT ANEFPCLPKQ VAWILATSKV FMYPELLPVC SLKAKNPQDK ILFTKAEDNK YLLTCKTARQ LTVRIKNLNM NRAPDNIIKF YKKTKQLPVL GKCCEEIQPH QWKPPIEREE HRLPFWLKAS LPSIQEELRH MADGAREVGN MTGTTEINSD QGLEKDNSEL GSETRYPLLL PKGVVLKLKP VADRFPKKAW RQKRSSVLKP LLIQPSPSLQ PSFNPGKTPA QSTHSEAPPS KMVLRIPHPI QPATVLQTVP GVPPLGVSGG ESFESPAALP AMPPEARTSF PLSESQTLLS SAPVPKVMMP SPASSMFRKP YVRRRPSKRR GARAFRCIKP APVIHPASVI FTVPATTVKI VSLGGGCNMI QPVNAAVAQS PQTIPIATLL VNPTSFPCPL NQPLVASSVS PLIVSGNSVN LPIPSTPEDK AHMNVDIACA VADGENAFQG LEPKLEPQEL SPLSATVFPK VEHSPGPPPV DKQCQEGLSE NSAYRWTVVK TEEGRQALEP LPQGIQESLN NSSPGDLEEV VKMEPEDATE EISGFL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation.
  • 基因功能参考文献：
    1. Data indicate WW-binding protein 2 (WBP2) as an important co-factor of YY1 associated protein 1 (YAP) that enhances YAP/TEAD-mediated gene transcription. PMID: 28332498
    2. Loss-of-Function Mutations in YY1AP1 Lead to Grange Syndrome and a Fibromuscular Dysplasia-Like Vascular Disease. PMID: 27939641
    3. YY1AP1 may serve as a key molecular target for EpCAM(+) AFP(+) HCC subtype PMID: 25597408
    4. human liver cancer associated gene PMID: 11856496
    5. YY1AP is a novel co-activator of YY1 PMID: 14744866
    6. HCCA2 may play a novel role in cell cycle regulation. PMID: 17541814

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  • 相关疾病：
    Grange syndrome (GRNG)
  • 亚细胞定位：
    Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus.
  • 组织特异性：
    Ubiquitous. Detected in small intestine, skeletal muscle, lung, pancreas, brain, stomach, spleen, colon and heart. Detected at very low levels in healthy liver. Highly expressed in most liver carcinomas.
  • 数据库链接：

    HGNC: 30935

    OMIM: 602531

    KEGG: hsa:55249

    STRING: 9606.ENSP00000357323

    UniGene: Hs.584927