WNT2 Antibody

1. Down-regulation of miR-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway through inhibition of Wnt2 and Fzd2. PMID: 29259372
2. The data suggest that Med19 expression correlates with aggressive characteristics of bladder cancer, and Med19 knockdown suppresses the proliferation and migration of cancer cells through down-regulating the Wnt/beta-catenin pathway. PMID: 28631286
3. The findings of this study have shown that molecular mechanisms, including aberrant activation of the WNT2 gene signaling pathway, may be involved in the pathogenesis of preeclampsia. PMID: 29109390
4. SNPs in WNT2 and FOXP2 are associated with clinical symptom severity of autism spectrum disorders. PMID: 28081867
5. WNT2 insufficiency might cause impaired trophoblast cell proliferation and migration via downregulation of Wnt/beta-catenin signaling pathway. PMID: 28627774
6. Three-dimensional organotypic co-culture assays revealed that WNT2-mediated fibroblast motility and extracellular matrix remodeling enhanced cancer cell invasion of cell lines even harboring mutations in the adenomatous polyposis coli/beta-catenin pathway. PMID: 28553956
7. Chondrogenic potential was higher and Wnt/beta-catenin signaling was more potently activated by a GSK-3beta inhibitor in the posterior than in the anterior part of the human infant sclera. PMID: 27336854
8. data enforced the evidence that knockdown of c-Fos inhibited cell proliferation, migration, and invasion, and promoted the apoptosis of OS cells accompanied by altered expression of Wnt2 and Fzd9 PMID: 28665975
9. High WNT2 expression is associated with Cervical Carcinoma Metastasis. PMID: 27513465
10. targeting beta-catenin with lipofection-delivered small interfering RNA oligonucleotide inhibited the proliferation and cell cycle arrest in G0/G1 phase and increased apoptosis of fibroblast cells, accompanied by downregulation of Wnt2 and cyclin D1 as well as the phosphorylation level of glycogen synthase kinase 3 beta in the keloid fibrosis PMID: 28656880
11. Genetic polymorphisms in the WNT2 and CTNNB1 genes were closely associated with hepatocellular carcinoma risk and progression in a Chinese Han population PMID: 28328801
12. The WNT2 rs39315 G allele was associated with advanced tumor stage in hepatocellular carcinoma. PMID: 26968103
13. Wnt2 complements Wnt/beta-catenin signaling in regulating colorectal cancer cell proliferation. PMID: 26484565
14. Wnt2/beta-catenin signaling was involved in stromal-epithelial cells interaction in endometriosis. PMID: 26116230
15. High expression of Wnt2 is associated with pancreatic cancer progression promoted by pancreatic stellate cells. PMID: 25731618
16. Hypermethylation of WNT2 is associated with colorectal cancer. PMID: 23694962
17. The study demonistrated that expressions of Wnt-2 in high-grade brainstem gliomas were significantly higher than that in low-grade brainstem gliomas and normal brain tissues and were positively correlated with the expression of Ki-67. PMID: 23603171
18. Decreased placental expression of Wnt2 and increased placental expression of sFRP4 may be associated with the pathogenesis of severe preeclampsia. PMID: 23322712
19. We demonstrated an activation of Wnt-2 signaling via the Frizzled-8 receptor in non-small cell lung cancer cells PMID: 23815780
20. The skin lesions of scleroderma patients showed obviously increased expression of cytoplasmic Wnt 2, nuclear Wnt 3a and beta-catenin, but markedly lowered cell membrane expression of beta-catenin than normal skin. PMID: 23268410
21. significant association with SNP rs4730775 locus on chromosome 7 with genetic susceptibility to Peyronie's disease PMID: 22489561
22. Pdgf signaling potentiates Wnt2-Wnt7b signaling to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper development of endoderm-derived organs, such as the lung PMID: 22949635
23. The WNT2 gene may play a suggestive role in language development in autistic disorder. PMID: 22522212
24. Expression of WNT2 in pancreatic cancer cells suppresses anoikis, enhances anchorage-independent sphere formation, and increases metastatic propensity in vivo. PMID: 22763454
25. Wnt/beta-catenin pathway forms a negative feedback loop during TGF-beta1 induced human normal skin fibroblast-to-myofibroblast transition PMID: 22041457
26. a haplotype of WNT2 (rs2896218-rs6950765: G-G) is significantly associated with ASDs. PMID: 21575668
27. DNA methylation within the WNT2 promoter in human placenta is associated with low birthweight. PMID: 21474991
28. findings provide evidence for a significant association between WNT2 and autism. PMID: 19895723
29. The present study does not support a major role for WNT2 in schizophrenia. PMID: 20492734
30. Wnt2/beta-catenin signaling pathway is constitutively activated in esophageal squamous cell carcinoma (ESCC) cells, indicating that Wnt2/beta-catenin pathway plays an essential role in carcinogenesis of the esophagus. PMID: 19857041
31. Wnt2 acts as an angiogenic factor for non-sinusoidal endothelium in vitro and in vivo. PMID: 19444628
32. Up-regulation of WNT2 mRNA by estrogen might play a key role in some cases of human breast cancer through activation of the beta-catenin - TCF signaling pathway. PMID: 11712082
33. Activating mutations of the WNT2 gene are not a major contributor to the development of autistic disorder. PMID: 11840514
34. REVIEW: role in human gastrointestinal cancer PMID: 14533014
35. Our interpretation of these findings is that it is unlikely that DNA variations in RELN and WNT2 play a significant role in the genetic predisposition to autism. PMID: 15048648
36. Target genes involved in tumor WNT pathways in response to TGF-beta1 were found in cervix cancer cells. PMID: 15878915
37. Wnt/beta-catenin signalling pathway is activated in most of gastric cancers, which may play pivotal roles either in gastric cancer formation or in tumour invasion and dissemination PMID: 15896469
38. Inhibition of Wnt2 by monoclonal antibodies is of therapeutic interest in the development of more effective treatments for malignnt pleueral mesothelioma. PMID: 15900580
39. The increased Wnt2 expression in gastric cancers is paralleled with reduction of membranous E-cadherin. PMID: 16132582
40. The WNT2 gene is upregulated along the progression from low-grade dysplasia to esophageal adenocarcioma. PMID: 16407829
41. Regulation of Fz4 expression by Wnt2. PMID: 17386109
42. inhibition of both Wnt-2 and Gal-3 had synergistic effects on suppressing canonical Wnt signaling and inducing apoptosis, suggesting that aberrant canonical Wnt/beta-catenin signaling in colorectal cancer can be regulated at multiple levels PMID: 17534895
43. potential coordinative effects of Wnt, NF-kappaB and/or Stat3 activation on gastric cancer formation presumably by promoting the transcription of their common target genes. PMID: 18184402
44. Persistent upregulation in colorectal carcinoma cases studied. PMID: 18600204
45. Wnt (Wnt2), Stat3, and Notch-1 and -2 signaling are correlated in human epidermal tumors. PMID: 18703315
46. Knockdown of Wnt2 by siRNA in human U251 glioma cells inhibited cell proliferation and invasive ability, and induced apoptotic cell death PMID: 18949017
47. The results suggest that WNT2 could act through its receptor FZD9 to regulate the beta-CATENIN pathway in cumulus cells, recruiting beta-CATENIN into plasma membranes and promoting the formation of adherens junctions involving CDH1. PMID: 19038973
48. up-regulation of the Wnt-2 protein might play a role in the development of colorectal cancers. PMID: 19239325
49. RNA samples from 21 neuroblastoma showed a highly significant FZD1 and/or MDR1 overexpression after treatment, underlining a role for FZD1-mediated Wnt/beta-catenin pathway in clinical chemoresistance. PMID: 19421142

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HGNC: 12780

OMIM: 147870

KEGG: hsa:7472

STRING: 9606.ENSP00000265441

UniGene: Hs.567356