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WDR83 Antibody

  • 货号：
    CSB-PA863110LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA863110LA01HU diluted at 1:300 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA863110LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) WDR83 Polyclonal antibody
  • Uniprot No.：
    Q9BRX9
  • 基因名：
    WDR83
  • 别名：
    MAPK organizer 1 antibody; MGC4238 antibody; Mitogen activated protein kinase organizer 1 antibody; Mitogen-activated protein kinase organizer 1 antibody; MORG 1 antibody; WD repeat domain-containing protein 83 antibody; wdr83 antibody; WDR83_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human WD repeat domain-containing protein 83 protein (64-315AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，WDR83 Antibody (CSB-PA863110LA01HU)，的标记方式是Non-conjugated。对于WDR83 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA863110LB01HU WDR83 Antibody, HRP conjugated ELISA
    FITC CSB-PA863110LC01HU WDR83 Antibody, FITC conjugated
    Biotin CSB-PA863110LD01HU WDR83 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator. May also be involved in pre-mRNA splicing.
  • 基因功能参考文献：
    1. Morg1 facilitates Par6-aPKC binding to Crb3 for definition of apical identity of epithelial cells. PMID: 23439680
    2. WDR83 and DHPS were capable of forming an RNA duplex at overlapping 3' untranslated regions and this duplex increased their mutual stability, which was required for the bidirectional regulation. PMID: 22491477
    3. Includes the identification of this protein in C complex spliceosomes. PMID: 11991638
    4. Functional characterization of the homologous rat gene. PMID: 16407229
    5. Component of a modular scaffold system that participates in the regulation of agonist-specific ERK signaling. PMID: 15118098
    6. Morg1 expression is reduced in human brain tissue with ischemic damage. Reactive astrocytes in the surrounding brain tissue showed strong Morg1 expression. PMID: 19429104

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    WD repeat MORG1 family
  • 数据库链接：

    HGNC: 32672

    KEGG: hsa:84292

    STRING: 9606.ENSP00000242796

    UniGene: Hs.657204