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WDR83 Antibody

  • 货号：
    CSB-PA005781
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of MCF7 cells using MAPK Organizer 1 Polyclonal Antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q9BRX9
  • 基因名：
    WDR83
  • 别名：
    MAPK organizer 1 antibody; MGC4238 antibody; Mitogen activated protein kinase organizer 1 antibody; Mitogen-activated protein kinase organizer 1 antibody; MORG 1 antibody; WD repeat domain-containing protein 83 antibody; wdr83 antibody; WDR83_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MAPK Organizer 1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator. May also be involved in pre-mRNA splicing.
  • 基因功能参考文献：
    1. Morg1 facilitates Par6-aPKC binding to Crb3 for definition of apical identity of epithelial cells. PMID: 23439680
    2. WDR83 and DHPS were capable of forming an RNA duplex at overlapping 3' untranslated regions and this duplex increased their mutual stability, which was required for the bidirectional regulation. PMID: 22491477
    3. Includes the identification of this protein in C complex spliceosomes. PMID: 11991638
    4. Functional characterization of the homologous rat gene. PMID: 16407229
    5. Component of a modular scaffold system that participates in the regulation of agonist-specific ERK signaling. PMID: 15118098
    6. Morg1 expression is reduced in human brain tissue with ischemic damage. Reactive astrocytes in the surrounding brain tissue showed strong Morg1 expression. PMID: 19429104

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    WD repeat MORG1 family
  • 数据库链接：

    HGNC: 32672

    KEGG: hsa:84292

    STRING: 9606.ENSP00000242796

    UniGene: Hs.657204