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VPS45 Antibody

  • 货号：
    CSB-PA025912GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NRW7
  • 基因名：
  • 别名：
    h-VPS45 antibody; H1 antibody; H1VPS45 antibody; HGNC:14579 antibody; hlVps45 antibody; Leucocyte vacuolar protein sorting 45 antibody; OTTHUMP00000014482 antibody; Vacuolar protein sorting 45 homolog (S. cerevisiae) antibody; Vacuolar protein sorting 45A (yeast homolog) antibody; Vacuolar protein sorting 45A antibody; Vacuolar protein sorting 45B (yeast) antibody; Vacuolar protein sorting-associated protein 45 antibody; Vps45 antibody; VPS45_HUMAN antibody; VPS45A antibody; VPS45B antibody; VPS54A antibody; VSP45 antibody; VSP45A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human VPS45
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.
  • 基因功能参考文献：
    1. A homozygous VPS45 p.E238K mutation is associated with severe congenital neutropenia with neurological impairment. PMID: 26358756
    2. we identified a Thr224Asn mutation in the VPS45 gene in infants from consanguineous families who suffered from life-threatening neutropenia. PMID: 23599270
    3. Defective endosomal intracellular protein trafficking due to biallelic mutations in VPS45 underlies a new immunodeficiency syndrome involving impaired neutrophil function. PMID: 23738510
    4. Data implicate hVps45 and Rabenosyn-5 in post early endosome transport, and suggest that their interaction serves as a nexus to promote bidirectional transport along the endosome-to-recycling compartment and endosome-to-Golgi axes. PMID: 19931244
  • 相关疾病：
    Neutropenia, severe congenital 5, autosomal recessive (SCN5)
  • 亚细胞定位：
    Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
  • 蛋白家族：
    STXBP/unc-18/SEC1 family
  • 组织特异性：
    Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver.
  • 数据库链接：

    HGNC: 14579

    OMIM: 610035

    KEGG: hsa:11311

    STRING: 9606.ENSP00000358126

    UniGene: Hs.443750