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  4. Recombinant Human Vacuolar protein sorting-associated protein 45 (VPS45)

Recombinant Human Vacuolar protein sorting-associated protein 45 (VPS45)

  • 中文名称：
    人VPS45重组蛋白
  • 货号：
    CSB-YP882092HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人VPS45重组蛋白
  • 货号：
    CSB-EP882092HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人VPS45重组蛋白
  • 货号：
    CSB-EP882092HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人VPS45重组蛋白
  • 货号：
    CSB-BP882092HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人VPS45重组蛋白
  • 货号：
    CSB-MP882092HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    h-VPS45; H1; H1VPS45; HGNC:14579; hlVps45; Leucocyte vacuolar protein sorting 45; OTTHUMP00000014482; Vacuolar protein sorting 45 homolog (S. cerevisiae); Vacuolar protein sorting 45A (yeast homolog); Vacuolar protein sorting 45A; Vacuolar protein sorting 45B (yeast); Vacuolar protein sorting-associated protein 45; Vps45; VPS45_HUMAN; VPS45A; VPS45B; VPS54A; VSP45; VSP45A
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-570
  • 氨基酸序列
    MNVVFAVKQY ISKMIEDSGP GMKVLLMDKE TTGIVSMVYT QSEILQKEVY LFERIDSQNR EIMKHLKAIC FLRPTKENVD YIIQELRRPK YTIYFIYFSN VISKSDVKSL AEADEQEVVA EVQEFYGDYI AVNPHLFSLN ILGCCQGRNW DPAQLSRTTQ GLTALLLSLK KCPMIRYQLS SEAAKRLAEC VKQVITKEYE LFEFRRTEVP PLLLILDRCD DAITPLLNQW TYQAMVHELL GINNNRIDLS RVPGISKDLR EVVLSAENDE FYANNMYLNF AEIGSNIKNL MEDFQKKKPK EQQKLESIAD MKAFVENYPQ FKKMSGTVSK HVTVVGELSR LVSERNLLEV SEVEQELACQ NDHSSALQNI KRLLQNPKVT EFDAARLVML YALHYERHSS NSLPGLMMDL RNKGVSEKYR KLVSAVVEYG GKRVRGSDLF SPKDAVAITK QFLKGLKGVE NVYTQHQPFL HETLDHLIKG RLKENLYPYL GPSTLRDRPQ DIIVFVIGGA TYEEALTVYN LNRTTPGVRI VLGGTTVHNT KSFLEEVLAS GLHSRSKESS QVTSRSASRR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.
  • 基因功能参考文献：
    1. A homozygous VPS45 p.E238K mutation is associated with severe congenital neutropenia with neurological impairment. PMID: 26358756
    2. we identified a Thr224Asn mutation in the VPS45 gene in infants from consanguineous families who suffered from life-threatening neutropenia. PMID: 23599270
    3. Defective endosomal intracellular protein trafficking due to biallelic mutations in VPS45 underlies a new immunodeficiency syndrome involving impaired neutrophil function. PMID: 23738510
    4. Data implicate hVps45 and Rabenosyn-5 in post early endosome transport, and suggest that their interaction serves as a nexus to promote bidirectional transport along the endosome-to-recycling compartment and endosome-to-Golgi axes. PMID: 19931244
  • 相关疾病：
    Neutropenia, severe congenital 5, autosomal recessive (SCN5)
  • 亚细胞定位：
    Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
  • 蛋白家族：
    STXBP/unc-18/SEC1 family
  • 组织特异性：
    Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver.
  • 数据库链接：

    HGNC: 14579

    OMIM: 610035

    KEGG: hsa:11311

    STRING: 9606.ENSP00000358126

    UniGene: Hs.443750