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Tf Antibody

  • 货号：
    CSB-PA856363LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA856363LA01MO diluted at 1:400 and staining in paraffin-embedded mouse liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Tf Polyclonal antibody
  • Uniprot No.：
    Q921I1
  • 基因名：
  • 别名：
    Tf antibody; Trf antibody; Serotransferrin antibody; Transferrin antibody; Beta-1 metal-binding globulin antibody; Siderophilin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse
  • 免疫原：
    Recombinant Mouse Serotransferrin protein (401-697AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Tf Antibody (CSB-PA856363LA01MO)，的标记方式是Non-conjugated。对于Tf Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA856363LB01MO Tf Antibody, HRP conjugated ELISA
    FITC CSB-PA856363LC01MO Tf Antibody, FITC conjugated
    Biotin CSB-PA856363LD01MO Tf Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
  • 基因功能参考文献：
    1. the value of transferrin receptors (TfRs)/cell reveals a 100-fold increase in the number of TfRs per bEnd3 cells compared to human umbilical vein cells. PMID: 27100851
    2. Identification of multiple transferrin species in the spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: The role of CD38. PMID: 26639305
    3. Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor. PMID: 23650374
    4. Together, these data indicate that Lcn2, in combination with transferrin, confines Klebsiella pneumoniae to the airways and prevents invasion into tissue containing the pulmonary vasculature. PMID: 23169997
    5. Transferrin(hpx/hpx) Hemojuvelin(+/+) and Transferrin(hpx/hpx) Hemojuvelin(-/-) phenotypes did not differ markedly, but RBC transfusions increased hepcidin levels in Transferrin(hpx/hpx) Hemojuvelin(+/+) but not Transferrin(hpx/hpx) Hemojuvelin(-/-)mice. PMID: 21993681
    6. These results indicate that CALM is required for erythroid maturation and transferrin internalization in mice. PMID: 22363754
    7. Neurodegenerative conditions involving iron-mediated toxicity may be due to a failure of iron transport or storage mechanisms, rather than to the presence of high levels of non-transferrin-bound iron. PMID: 20431983
    8. Apotransferrin mitigates the neurotoxicity of hemoglobin in a cell culture model of intracerebral hemorrhage. PMID: 21034753
    9. Descibed is the 2.4 A structure of inhibitor of carbonic anhydrase from a pseudomerohedral twinned crystal: a member of the transferrin superfamily. PMID: 20572014
    10. transferrin receptor 2 and HFE are involved in holotransferrin-dependent signaling for the regulation of furin which involved Erk phosphorylation. Furin in turn may control hepcidin expression. PMID: 20634490
    11. hepcidin expression in hypotransferrinemic mice is regulated both by transferrin-restricted erythropoiesis and by transferrin through a mechanism independent of its role in erythropoiesis PMID: 20956801
    12. These data show that mycobacteria reside in the Rab11(+) endocytic recycling pathway, thereby retaining access to metabolizing transferrin and avoiding endocytosed immunoproteins like Lcn2. PMID: 20121435
    13. during later times postinfection (1.5 to 3 h), the virus meets up with transferrin in the Rab11-positive recycling endosome PMID: 16611921
    14. Transsferrin overexpression has negative effects on testicular function and that transfserrin levels require strict regulation in the testis. PMID: 16998850
    15. developing erythroid cells, which are taking up vast amounts of Fe, deliver the metal directly from transferrin-containing endosomes to mitochondria PMID: 17376890
    16. The role of transferrin in glial protection was investigated. PMID: 18509548
    17. Data show that the transferrin receptor TfR1 provided transferrin to the ureteric bud, but not to the capsule or the stroma, and that Scara5 bound serum ferritin and then stimulated its endocytosis from the cell surface with consequent iron delivery. PMID: 19154717

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Transferrin family
  • 组织特异性：
    Expressed by the liver and secreted in plasma.
  • 数据库链接：

    KEGG: mmu:22041

    STRING: 10090.ENSMUSP00000035158

    UniGene: Mm.37214