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  4. TRIP10 Antibody

TRIP10 Antibody

  • 货号：
    CSB-PA024523GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q15642
  • 基因名：
  • 别名：
    Cdc42 interacting protein 4 antibody; Cdc42 interaction protein 4 long isoform antibody; Cdc42-interacting protein 4 antibody; CG11341 antibody; CG15015 PA antibody; Cip 4 antibody; CIP4 antibody; CIP4_HUMAN antibody; DCIP4 antibody; hSTP antibody; Protein Felic antibody; Salt tolerant protein antibody; Salt tolerator antibody; STOT antibody; STP antibody; Thyroid hormone receptor interactor 10 antibody; Thyroid receptor interacting protein 10 antibody; Thyroid receptor-interacting protein 10 antibody; TR-interacting protein 10 antibody; TRIP 10 antibody; TRIP-10 antibody; trip10 antibody; Truncated Cdc42 interaction protein 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TRIP10
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
  • 基因功能参考文献：
    1. Data show that CIP4 is highly expressed in nasopharyngeal carcinoma (NPC) tissues and is associated with poor prognosis. Also, the study provides evidence that CIP4 plays an important role in the promotion of NPC metastasis by mediating invadopodia formation and activating the EGFR pathway. PMID: 28129778
    2. results support a model in which AKAP350 recruits CIP4 to the centrosome, providing a centrosomal scaffold to integrate microtubule and actin dynamics, thus enabling centrosome polarization and ensuring cell migration directionality. PMID: 26208639
    3. CIP4 promotes metastasis in Triple negative breast cancer and is associated with poor prognosis. PMID: 25823823
    4. CIP4 is a positive regulator of non small lung carcinoma metastasis and a potential poor prognostic biomarker in lung adenocarcinoma. PMID: 25174397
    5. CIP4 controls cell-cell cohesion and is required for the acquisition of an invasive phenotype in breast tumors PMID: 25203208
    6. CIP4 plays a significant role in the intracellular hypertrophic signal transduction network that controls the growth of cardiac myocytes in heart disease. PMID: 23915320
    7. Study reveals a critical role of CIP4 in mediating chemotaxis of CLL cells by controlling the dynamics of microspike-containing protrusions and cell steering. PMID: 23644527
    8. Trip10 regulates cancer cell growth and death in a cancer type-specific manner. Differential DNA methylation of Trip10 can either promote cell survival or cell death in a cell type-dependent manner. PMID: 21299869
    9. CIP4 overexpression is associated with breast cancer. PMID: 20940394
    10. Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms PMID: 12054674
    11. CIP4 accumulation and cellular toxicity may have a role in Huntington's disease pathogenesis PMID: 12604778
    12. These results indicate that CIP4 is critical for beta-catenin-mediated cell-cell adhesion. PMID: 16343437
    13. Data showed the SH3 domain of CIP4 was bound to DAAM1 in vivo. PMID: 16630611
    14. CIP4 is an important cytoskeletal adaptor that functions after filamentous actin accumulation and Cdc42 activation to enable microtubule organizing center polarization and NK cell cytotoxicity PMID: 17785506
    15. Cdc42-Interacting Protein-4 and FNBP1L protein potentially regulate later events in Epidermal Growth Factor Receptor endocytic trafficking that limits compartmentalized EGFR signaling. PMID: 19632321
    16. FNBP1 family proteins (FNBP1 and TRIP10) consist of FCH, FBH and SH3 domains. PMID: 12736724

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup.; [Isoform 5]: Cytoplasm, perinuclear region.
  • 蛋白家族：
    FNBP1 family
  • 组织特异性：
    Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.
  • 数据库链接：

    HGNC: 12304

    OMIM: 604504

    KEGG: hsa:9322

    UniGene: Hs.515094