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  4. Recombinant Human Cdc42-interacting protein 4 (TRIP10)

Recombinant Human Cdc42-interacting protein 4 (TRIP10)

  • 货号：
    CSB-YP624029HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP624029HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP624029HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP624029HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP624029HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cdc42 interacting protein 4; Cdc42 interaction protein 4 long isoform; Cdc42-interacting protein 4; CG11341; CG15015 PA; Cip 4; CIP4; CIP4_HUMAN; DCIP4; hSTP; Protein Felic; Salt tolerant protein; Salt tolerator; STOT; STP; Thyroid hormone receptor interactor 10; Thyroid receptor interacting protein 10; Thyroid receptor-interacting protein 10; TR-interacting protein 10; TRIP 10; TRIP-10; trip10; Truncated Cdc42 interaction protein 4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-601
  • 氨基酸序列
    MDWGTELWDQ FEVLERHTQW GLDLLDRYVK FVKERTEVEQ AYAKQLRSLV KKYLPKRPAK DDPESKFSQQ QSFVQILQEV NDFAGQRELV AENLSVRVCL ELTKYSQEMK QERKMHFQEG RRAQQQLENG FKQLENSKRK FERDCREAEK AAQTAERLDQ DINATKADVE KAKQQAHLRS HMAEESKNEY AAQLQRFNRD QAHFYFSQMP QIFDKLQDMD ERRATRLGAG YGLLSEAELE VVPIIAKCLE GMKVAANAVD PKNDSHVLIE LHKSGFARPG DVEFEDFSQP MNRAPSDSSL GTPSDGRPEL RGPGRSRTKR WPFGKKNKPR PPPLSPLGGP VPSALPNGPP SPRSGRDPLA ILSEISKSVK PRLASFRSLR GSRGTVVTED FSHLPPEQQR KRLQQQLEER SRELQKEVDQ REALKKMKDV YEKTPQMGDP ASLEPQIAET LSNIERLKLE VQKYEAWLAE AESRVLSNRG DSLSRHARPP DPPASAPPDS SSNSASQDTK ESSEEPPSEE SQDTPIYTEF DEDFEEEPTS PIGHCVAIYH FEGSSEGTIS MAEGEDLSLM EEDKGDGWTR VRRKEGGEGY VPTSYLRVTL N
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
  • 基因功能参考文献：
    1. Data show that CIP4 is highly expressed in nasopharyngeal carcinoma (NPC) tissues and is associated with poor prognosis. Also, the study provides evidence that CIP4 plays an important role in the promotion of NPC metastasis by mediating invadopodia formation and activating the EGFR pathway. PMID: 28129778
    2. results support a model in which AKAP350 recruits CIP4 to the centrosome, providing a centrosomal scaffold to integrate microtubule and actin dynamics, thus enabling centrosome polarization and ensuring cell migration directionality. PMID: 26208639
    3. CIP4 promotes metastasis in Triple negative breast cancer and is associated with poor prognosis. PMID: 25823823
    4. CIP4 is a positive regulator of non small lung carcinoma metastasis and a potential poor prognostic biomarker in lung adenocarcinoma. PMID: 25174397
    5. CIP4 controls cell-cell cohesion and is required for the acquisition of an invasive phenotype in breast tumors PMID: 25203208
    6. CIP4 plays a significant role in the intracellular hypertrophic signal transduction network that controls the growth of cardiac myocytes in heart disease. PMID: 23915320
    7. Study reveals a critical role of CIP4 in mediating chemotaxis of CLL cells by controlling the dynamics of microspike-containing protrusions and cell steering. PMID: 23644527
    8. Trip10 regulates cancer cell growth and death in a cancer type-specific manner. Differential DNA methylation of Trip10 can either promote cell survival or cell death in a cell type-dependent manner. PMID: 21299869
    9. CIP4 overexpression is associated with breast cancer. PMID: 20940394
    10. Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms PMID: 12054674
    11. CIP4 accumulation and cellular toxicity may have a role in Huntington's disease pathogenesis PMID: 12604778
    12. These results indicate that CIP4 is critical for beta-catenin-mediated cell-cell adhesion. PMID: 16343437
    13. Data showed the SH3 domain of CIP4 was bound to DAAM1 in vivo. PMID: 16630611
    14. CIP4 is an important cytoskeletal adaptor that functions after filamentous actin accumulation and Cdc42 activation to enable microtubule organizing center polarization and NK cell cytotoxicity PMID: 17785506
    15. Cdc42-Interacting Protein-4 and FNBP1L protein potentially regulate later events in Epidermal Growth Factor Receptor endocytic trafficking that limits compartmentalized EGFR signaling. PMID: 19632321
    16. FNBP1 family proteins (FNBP1 and TRIP10) consist of FCH, FBH and SH3 domains. PMID: 12736724

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup.; [Isoform 5]: Cytoplasm, perinuclear region.
  • 蛋白家族：
    FNBP1 family
  • 组织特异性：
    Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.
  • 数据库链接：

    HGNC: 12304

    OMIM: 604504

    KEGG: hsa:9322

    UniGene: Hs.515094