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TRIM29 Antibody

  • 货号：
    CSB-PA289988
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA289988(TRIM29 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA289988(TRIM29 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HT29 cells, Primary antibody: CSB-PA289988(TRIM29 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q14134
  • 基因名：
    TRIM29
  • 别名：
    Ataxia telangiectasia group D associated protein antibody; Ataxia telangiectasia group D-associated protein antibody; ATDC antibody; FLJ36085 antibody; TRI29_HUMAN antibody; TRIM 29 antibody; TRIM29 antibody; Tripartite motif containing 29 antibody; Tripartite motif containing protein 29 antibody; Tripartite motif protein 29 antibody; Tripartite motif protein TRIM29 antibody; Tripartite motif-containing protein 29 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human TRIM29
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
  • 基因功能参考文献：
    1. decreased expression of miR-122 and increased expression of TRIM29 was significantly associated with poor prognosis in patients with NPC. PMID: 29693120
    2. Ectopic expression of TRIM29 potentially contributes to metastasis and poor prognosis in patients with osteosarcoma. PMID: 28731167
    3. Knockdown of tripartite motif-containing 29 protein (TRIM29) enhanced the production of type I interferon in human and mouse dendritic cells by up to fourfold in response to intracellular herpes simplex virus. PMID: 29038422
    4. the current study demonstrated that TRIM29 upregulates cyclin and Bcl family proteins level to facilitate malignant cell growth and inhibit drug-induced apoptosis in bladder cancer, possibly through PKC-NF-kappaB signaling pathways. PMID: 26987391
    5. High TRIM29 expression is associated with metastasis of nasopharyngeal carcinoma. PMID: 26872369
    6. Data show that TRIM29 promotes tumor progression by activating Wnt/beta-Catenin signaling. PMID: 27081037
    7. This study establishes TRIM29 as a hypoxia-induced tumor suppressor gene and provides a novel molecular mechanism for ATM-dependent breast cancer suppression. PMID: 27535224
    8. Upregulation of TRIM29 is associated with thyroid cancer. PMID: 28098872
    9. miR-761 acts as an oncogene in triple-negative breast cancer. This mode of action can, at least partially, be ascribed to the down-regulation of its target TRIM29. PMID: 28054302
    10. Silencing of TRIM29 significantly inhibited the migration and invasion ability of CRC cells. PMID: 27430345
    11. Findings established a role for ATDC/TRIM29 as a robust pathogenic driver of bladder cancer development, identified downstream effector pathways, and implicated ATDC as a candidate biomarker and therapeutic target. PMID: 26471361
    12. define a novel function for ATDC in the RNF8-mediated DNA damage response and implicate RNF8 binding as a key determinant of the radioprotective function of ATDC PMID: 26381412
    13. Results suggest that TRIM29 functions as an oncogene in gastric cancer and is regulated by miR-185. PMID: 26191199
    14. TRIM29 functions as a scaffold protein to assemble DNA repair proteins into chromatin followed by efficient activation of DNA damage response. PMID: 26095369
    15. These findings suggest that TRIM29 regulates the p63-mediated pathway and the behavior of cervical cancer cells. PMID: 26071105
    16. Down-regulation of ATDC inhibits the growth and proliferation of esophageal carcinoma cells. PMID: 25491629
    17. TRIM29 may be useful marker for distinguishing prostate cancers from benign tissues PMID: 24485335
    18. TWIST1 inhibited TRIM29 promoter activity. PMID: 24950909
    19. TRIM29 promotes tumor progression and may be a novel prognostic marker for pancreatic ductal adenocarcinoma. PMID: 24864129
    20. Down-regulation of TRIM29 inhibited tumor cell proliferation in vitro. PMID: 24078150
    21. ATDC mRNA and protein expression were significantly higher in esophageal squamous cell carcinoma tissue than in matched noncancerous tissues. PMID: 23020249
    22. Ataxia-telangiectasia group D-associated gene (ATDC) mediates resistance to ionizing radiation. PMID: 24469230
    23. The expressions of TrkB and TRIM29 are correlated with lymph node metastasis in gastric cancer. PMID: 22490895
    24. The interaction between TRIM29 and beta-catenin may participate in the development of lung squamous cell carcinoma. PMID: 22721621
    25. results suggest that loss of TRIM29 expression in normal breast luminal cells can contribute to malignant transformation and lead to progression of ER+ breast cancer in premenopausal women. PMID: 22138580
    26. Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein PMID: 20947501
    27. TRIM29 allows keratinocytes to enter a protective alternative differentiation process rather than die massively after stress. PMID: 20454669
    28. ATDC increases cell proliferation via inhibition of p53 nuclear activities. PMID: 20368352
    29. suppressed ATDC expression is associated with malignant phenotype. PMID: 16890201
    30. TRIM29 is upregulated after radical prostatectomy for prostatic neoplasms. PMID: 17448597
    31. ATDC was found to stabilize beta-catenin via ATDC-induced effects on the Disheveled-2 protein, a negative regulator of glycogen synthase kinase 3beta in the Wnt/beta-catenin signaling pathway. PMID: 19249679
    32. the percentage of lung carcinoma patients remaining unclassifiable by TTF-1/TP63 was twice that of the five-antibody (TRIM29, CEACAM5, SLC7A5, MUC1, and CK5/6) test PMID: 19430419

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  • 亚细胞定位：
    Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments.
  • 组织特异性：
    Expressed in placenta, prostate and thymus.
  • 数据库链接：

    HGNC: 17274

    OMIM: 610658

    KEGG: hsa:23650

    STRING: 9606.ENSP00000343129

    UniGene: Hs.504115