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  4. Recombinant Human Tripartite motif-containing protein 29 (TRIM29)

Recombinant Human Tripartite motif-containing protein 29 (TRIM29)

  • 货号：
    CSB-YP618875HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP618875HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP618875HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP618875HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP618875HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TRIM29
  • Uniprot No.：
  • 别名：
    Ataxia telangiectasia group D associated protein; Ataxia telangiectasia group D-associated protein; ATDC; FLJ36085; TRI29_HUMAN; TRIM 29; TRIM29; Tripartite motif containing 29; Tripartite motif containing protein 29; Tripartite motif protein 29; Tripartite motif protein TRIM29; Tripartite motif-containing protein 29
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-588
  • 氨基酸序列
    MEAADASRSN GSSPEARDAR SPSGPSGSLE NGTKADGKDA KTTNGHGGEA AEGKSLGSAL KPGEGRSALF AGNEWRRPII QFVESGDDKN SNYFSMDSME GKRSPYAGLQ LGAAKKPPVT FAEKGELRKS IFSESRKPTV SIMEPGETRR NSYPRADTGL FSRSKSGSEE VLCDSCIGNK QKAVKSCLVC QASFCELHLK PHLEGAAFRD HQLLEPIRDF EARKCPVHGK TMELFCQTDQ TCICYLCMFQ EHKNHSTVTV EEAKAEKETE LSLQKEQLQL KIIEIEDEAE KWQKEKDRIK SFTTNEKAIL EQNFRDLVRD LEKQKEEVRA ALEQREQDAV DQVKVIMDAL DERAKVLHED KQTREQLHSI SDSVLFLQEF GALMSNYSLP PPLPTYHVLL EGEGLGQSLG NFKDDLLNVC MRHVEKMCKA DLSRNFIERN HMENGGDHRY VNNYTNSFGG EWSAPDTMKR YSMYLTPKGG VRTSYQPSSP GRFTKETTQK NFNNLYGTKG NYTSRVWEYS SSIQNSDNDL PVVQGSSSFS LKGYPSLMRS QSPKAQPQTW KSGKQTMLSH YRPFYVNKGN GIGSNEAP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
  • 基因功能参考文献：
    1. decreased expression of miR-122 and increased expression of TRIM29 was significantly associated with poor prognosis in patients with NPC. PMID: 29693120
    2. Ectopic expression of TRIM29 potentially contributes to metastasis and poor prognosis in patients with osteosarcoma. PMID: 28731167
    3. Knockdown of tripartite motif-containing 29 protein (TRIM29) enhanced the production of type I interferon in human and mouse dendritic cells by up to fourfold in response to intracellular herpes simplex virus. PMID: 29038422
    4. the current study demonstrated that TRIM29 upregulates cyclin and Bcl family proteins level to facilitate malignant cell growth and inhibit drug-induced apoptosis in bladder cancer, possibly through PKC-NF-kappaB signaling pathways. PMID: 26987391
    5. High TRIM29 expression is associated with metastasis of nasopharyngeal carcinoma. PMID: 26872369
    6. Data show that TRIM29 promotes tumor progression by activating Wnt/beta-Catenin signaling. PMID: 27081037
    7. This study establishes TRIM29 as a hypoxia-induced tumor suppressor gene and provides a novel molecular mechanism for ATM-dependent breast cancer suppression. PMID: 27535224
    8. Upregulation of TRIM29 is associated with thyroid cancer. PMID: 28098872
    9. miR-761 acts as an oncogene in triple-negative breast cancer. This mode of action can, at least partially, be ascribed to the down-regulation of its target TRIM29. PMID: 28054302
    10. Silencing of TRIM29 significantly inhibited the migration and invasion ability of CRC cells. PMID: 27430345
    11. Findings established a role for ATDC/TRIM29 as a robust pathogenic driver of bladder cancer development, identified downstream effector pathways, and implicated ATDC as a candidate biomarker and therapeutic target. PMID: 26471361
    12. define a novel function for ATDC in the RNF8-mediated DNA damage response and implicate RNF8 binding as a key determinant of the radioprotective function of ATDC PMID: 26381412
    13. Results suggest that TRIM29 functions as an oncogene in gastric cancer and is regulated by miR-185. PMID: 26191199
    14. TRIM29 functions as a scaffold protein to assemble DNA repair proteins into chromatin followed by efficient activation of DNA damage response. PMID: 26095369
    15. These findings suggest that TRIM29 regulates the p63-mediated pathway and the behavior of cervical cancer cells. PMID: 26071105
    16. Down-regulation of ATDC inhibits the growth and proliferation of esophageal carcinoma cells. PMID: 25491629
    17. TRIM29 may be useful marker for distinguishing prostate cancers from benign tissues PMID: 24485335
    18. TWIST1 inhibited TRIM29 promoter activity. PMID: 24950909
    19. TRIM29 promotes tumor progression and may be a novel prognostic marker for pancreatic ductal adenocarcinoma. PMID: 24864129
    20. Down-regulation of TRIM29 inhibited tumor cell proliferation in vitro. PMID: 24078150
    21. ATDC mRNA and protein expression were significantly higher in esophageal squamous cell carcinoma tissue than in matched noncancerous tissues. PMID: 23020249
    22. Ataxia-telangiectasia group D-associated gene (ATDC) mediates resistance to ionizing radiation. PMID: 24469230
    23. The expressions of TrkB and TRIM29 are correlated with lymph node metastasis in gastric cancer. PMID: 22490895
    24. The interaction between TRIM29 and beta-catenin may participate in the development of lung squamous cell carcinoma. PMID: 22721621
    25. results suggest that loss of TRIM29 expression in normal breast luminal cells can contribute to malignant transformation and lead to progression of ER+ breast cancer in premenopausal women. PMID: 22138580
    26. Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein PMID: 20947501
    27. TRIM29 allows keratinocytes to enter a protective alternative differentiation process rather than die massively after stress. PMID: 20454669
    28. ATDC increases cell proliferation via inhibition of p53 nuclear activities. PMID: 20368352
    29. suppressed ATDC expression is associated with malignant phenotype. PMID: 16890201
    30. TRIM29 is upregulated after radical prostatectomy for prostatic neoplasms. PMID: 17448597
    31. ATDC was found to stabilize beta-catenin via ATDC-induced effects on the Disheveled-2 protein, a negative regulator of glycogen synthase kinase 3beta in the Wnt/beta-catenin signaling pathway. PMID: 19249679
    32. the percentage of lung carcinoma patients remaining unclassifiable by TTF-1/TP63 was twice that of the five-antibody (TRIM29, CEACAM5, SLC7A5, MUC1, and CK5/6) test PMID: 19430419

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  • 亚细胞定位：
    Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments.
  • 组织特异性：
    Expressed in placenta, prostate and thymus.
  • 数据库链接：

    HGNC: 17274

    OMIM: 610658

    KEGG: hsa:23650

    STRING: 9606.ENSP00000343129

    UniGene: Hs.504115