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TIE1 Antibody

  • 货号：
    CSB-PA050264
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P35590
  • 基因名：
    TIE1
  • 别名：
    JKT 14 antibody; JTK14 antibody; TIE antibody; Tie1 antibody; TIE1_HUMAN antibody; Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1 antibody; Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains antibody; Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 antibody; Tyrosine protein kinase receptor Tie 1 antibody; Tyrosine-protein kinase receptor Tie-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Tie-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
  • 基因功能参考文献：
    1. We identified colorectal cancer as a novel Tie1-expressing tumor, with Tie1-positive cells hardly detectable in the normal intestine. Tie1 expression did not influence cancer cell proliferation in regular in vitro cultures, but significantly affected malignant growth of transplanted tumors in vivo. PMID: 28464467
    2. T794A-expressing human umbilical vein endothelial cells formed significantly shorter tubes with fewer branches in three-dimensional Matrigel cultures, but did not alter Tie1 or Tie2 tyrosine phosphorylation or downstream signaling. PMID: 26436659
    3. The decreasing expression of Tie1 may play an important role in the pathogenesis of primary lower extremity varicose veins. PMID: 22987233
    4. Data propose that EndMT associated with Tie1 downregulation participates in the pathological development of stroma observed in tumours. PMID: 22421998
    5. The Tie-1 immunoreactivity was dominantly observed in the heamangiogenic cells and cells cords, whereas the matured villi showed immunoreactivity only in other components. PMID: 20164029
    6. A natural antisense transcript was identified for tyrosine kinase containing immunoglobulin and epidermal growth factor homology domain-1 (tie-1), tie-1AS long noncoding RNA in zebrafish, mouse, and humans. PMID: 19880500
    7. high expression independently associated with shorter survival in patients with early chronic phase CML PMID: 11920509
    8. Overexpression and activation of Tie1 is associated with breast and colonic neopalsms PMID: 17786322
    9. the trophoblastic shell of the very early human placenta, as well as endothelial cells and ACC exhibited strong staining intensity for Tie-1 PMID: 18675456
    10. Tie-1 has an inflammatory function in endothelial cells. PMID: 19236867

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Tie subfamily
  • 组织特异性：
    Specifically expressed in developing vascular endothelial cells.
  • 数据库链接：

    HGNC: 11809

    OMIM: 600222

    KEGG: hsa:7075

    STRING: 9606.ENSP00000361554

    UniGene: Hs.78824