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THSD1 Antibody

  • 货号：
    CSB-PA776650
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA776650(THSD1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9NS62
  • 基因名：
    THSD1
  • 别名：
    4833423O18Rik antibody; MGC74971 antibody; Thrombospondin type 1 domain containing protein 1 antibody; Thrombospondin type I domain 1 antibody; Thrombospondin type-1 domain-containing protein 1 antibody; Thrombospondin, type I, domain containing 1 antibody; THSD1 antibody; THSD1_HUMAN antibody; TMTSP antibody; Transmembrane molecule with thrombospondin module antibody; UNQ3010 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human THSD1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix.
  • 基因功能参考文献：
    1. THSD1 forms a multimeric protein complex with FAK/talin/vinculin, wherein THSD1 promotes talin binding to FAK but not to vinculin, a key step in nascent adhesion assembly. PMID: 29069646
    2. THSD1 mutation associated with Intracranial Aneurysm and Subarachnoid Hemorrhage. PMID: 27895300
    3. thrombospondin type I domain 1 is a new regulator of endothelial barrier function during vascular development and protects intraplaque microvessels against haemorrhaging in advanced atherosclerotic lesions PMID: 26822228
    4. The THSD1 gene may play a role in the tumorigenesis of colorectal cancer PMID: 22664866
    5. Thrombospondin has a role in inducing RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly PMID: 15371459
    6. The strong immunolocalization of thrombospondin (TSP) in the outer anulus of the intervertebral disc indicates a role for TSP in the avascular status of the adult human disc. PMID: 17047544
    7. These findings suggest that THSD1 is a good candidate tumor suppressor gene. PMID: 18403638

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  • 亚细胞定位：
    [Isoform 1]: Endosome membrane; Single-pass type I membrane protein. Cell junction, focal adhesion.; [Isoform 2]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
  • 数据库链接：

    HGNC: 17754

    KEGG: hsa:55901

    STRING: 9606.ENSP00000258613

    UniGene: Hs.325667