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  4. Recombinant Human Thrombospondin type-1 domain-containing protein 1 (THSD1), partial

Recombinant Human Thrombospondin type-1 domain-containing protein 1 (THSD1), partial

  • 中文名称：
    人THSD1重组蛋白
  • 货号：
    CSB-YP873644HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人THSD1重组蛋白
  • 货号：
    CSB-EP873644HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人THSD1重组蛋白
  • 货号：
    CSB-EP873644HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人THSD1重组蛋白
  • 货号：
    CSB-BP873644HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人THSD1重组蛋白
  • 货号：
    CSB-MP873644HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    THSD1
  • Uniprot No.：
  • 别名：
    4833423O18Rik; MGC74971; Thrombospondin type 1 domain containing protein 1; Thrombospondin type I domain 1; Thrombospondin type-1 domain-containing protein 1; Thrombospondin, type I, domain containing 1; THSD1; THSD1_HUMAN; TMTSP; Transmembrane molecule with thrombospondin module; UNQ3010
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix.
  • 基因功能参考文献：
    1. THSD1 forms a multimeric protein complex with FAK/talin/vinculin, wherein THSD1 promotes talin binding to FAK but not to vinculin, a key step in nascent adhesion assembly. PMID: 29069646
    2. THSD1 mutation associated with Intracranial Aneurysm and Subarachnoid Hemorrhage. PMID: 27895300
    3. thrombospondin type I domain 1 is a new regulator of endothelial barrier function during vascular development and protects intraplaque microvessels against haemorrhaging in advanced atherosclerotic lesions PMID: 26822228
    4. The THSD1 gene may play a role in the tumorigenesis of colorectal cancer PMID: 22664866
    5. Thrombospondin has a role in inducing RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly PMID: 15371459
    6. The strong immunolocalization of thrombospondin (TSP) in the outer anulus of the intervertebral disc indicates a role for TSP in the avascular status of the adult human disc. PMID: 17047544
    7. These findings suggest that THSD1 is a good candidate tumor suppressor gene. PMID: 18403638

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  • 亚细胞定位：
    [Isoform 1]: Endosome membrane; Single-pass type I membrane protein. Cell junction, focal adhesion.; [Isoform 2]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
  • 数据库链接：

    HGNC: 17754

    KEGG: hsa:55901

    STRING: 9606.ENSP00000258613

    UniGene: Hs.325667