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  4. TES Antibody
  • 货号：
    CSB-PA890679LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: 293 whole cell lysate, Hela whole cell lysate
      All lanes: TES antibody at 2.92µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 48, 47 kDa
      Observed band size: 48 kDa
    • IHC image of CSB-PA890679LA01HU diluted at 1:800 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA890679LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TES Polyclonal antibody
  • Uniprot No.：
    Q9UGI8
  • 基因名：
    TES
  • 别名：
    DKFZP586B2022 antibody; MGC1146 antibody; TES antibody; TES_HUMAN antibody; TESS 2 antibody; TESS antibody; TESS2 antibody; Testin antibody; Testis derived transcript (3 LIM domains) antibody; Testis derived transcript antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Testin protein (130-260AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TES Antibody (CSB-PA890679LA01HU)，的标记方式是Non-conjugated。对于TES Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA890679LB01HU TES Antibody, HRP conjugated ELISA
    FITC CSB-PA890679LC01HU TES Antibody, FITC conjugated
    Biotin CSB-PA890679LD01HU TES Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
    IF 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.
  • 基因功能参考文献：
    1. validated two new TES cocomplex partners: TGFB1I1 and a short form of the glucocorticoid receptor. TES and TGFB1I1 are shown to oppositely affect cell spreading providing biological validity for their copresence in complexes since they act in similar processes PMID: 28378594
    2. these data indicate that TES functions as a necessary suppressor of colorectal cancer progression by activating p38-MAPK signaling pathways. PMID: 27323777
    3. testin region (amino acids 52-233) harbouring the PET domain interacts with the C-terminal LIM1-2 domains PMID: 28542564
    4. Testin plays an important role in the development and progression of non-small cell lung cancer. Testin is a tumor suppressor. PMID: 28000866
    5. VASP, zyxin and TES are tension-dependent members of focal adherens junctions independent of the alpha-catenin-vinculin module. PMID: 26611125
    6. we confirm that the TES promoter is unmethylated in normal adult and fetal tissues. Re-expression of TESTIN protein in acute lymphoblastic leukemia cells using expression plasmid transfection results in rapid cell death or cell cycle arrest. PMID: 26985820
    7. Loss of TES gene expression is associated with nasopharyngeal carcinoma. PMID: 25824796
    8. findings suggest that the TES gene is a novel tumor suppressor gene PMID: 25498217
    9. TESTIN was hypermethylated in 43.7% endometrial cancer tissues (p < 0.001). Moreover, TESTIN hypermethylation was significantly correlated with advanced tumor stage, deep myometrial invasion and lymphatic node metastasis. PMID: 25720371
    10. Downregulation of TES was associated with breast cancer. PMID: 25119600
    11. TESTIN was commonly downregulated in human endometrial carcinoma and was associated with poor prognostic markers. PMID: 24929083
    12. A further significant correlation was observed between TES downregulation and the luminal B subtype independent of survivin expression. PMID: 23715752
    13. TES, as a valuable marker of breast cancer prognosis, plays an important role in the development and progression of breast cancer. TES may be an effective novel target in breast cancer prevention and treatment. PMID: 22957844
    14. Low TES gene expression is associated with coronary artery disease. PMID: 22156939
    15. Alterations of TES mRNA level may predict the location of metastasis. CAV1 possibly affect the cancer cell invasion PMID: 22201996
    16. These results suggest an interplay between the CaR and testin in the regulation of CaR-mediated Rho signalling with possible effects on the cytoskeleton. PMID: 21843504
    17. data implicate TES methylation in ALL and provide additional evidence for the involvement of LIM domain proteins in leukaemogenesis PMID: 20573277
    18. results support the role of TES as a TSG in gastric carcinogenesis and that TES is inactivated primarily by LOH and CpG island methylation PMID: 20626849
    19. The expression level of TES is significantly down-regulated in primary gastric cancer. PMID: 18799041
    20. TES gene functions as a tumor suppressor gene and is frequently silenced by hypermethylation and loss of heterozygosity in ovarian cancers. PMID: 20180808
    21. TES is best candidate tumor suppressor gene at 7q31 in prostate tumors PMID: 15252854
    22. Loss of TES from focal adhesions results in loss of actin stress fibres. PMID: 15662727
    23. Oservations identify Tes as an atypical binding partner of EVH1 domain of Mena and a regulator specific to a single Ena/VASP family member. PMID: 18158903
    24. Results suggest that testin has different conformational states in different cellular compartments, and a "closed" conformational state of TES may be involved in nucleolar localization. PMID: 18696217
    25. Inactivation of TESTIN is involved in head and neck carcinogenesis through its downregulation. PMID: 19289703

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  • 亚细胞定位：
    Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers.
  • 蛋白家族：
    Prickle / espinas / testin family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 14620

    OMIM: 606085

    KEGG: hsa:26136

    STRING: 9606.ENSP00000350937

    UniGene: Hs.592286