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  4. Recombinant Human Testin (TES)

Recombinant Human Testin (TES)

  • 货号：
    CSB-YP890679HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP890679HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP890679HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP890679HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP890679HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TES
  • Uniprot No.：
  • 别名：
    DKFZP586B2022; MGC1146; TES; TES_HUMAN; TESS 2; TESS; TESS2; Testin; Testis derived transcript (3 LIM domains); Testis derived transcript
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-421
  • 氨基酸序列
    MDLENKVKKM GLGHEQGFGA PCLKCKEKCE GFELHFWRKI CRNCKCGQEE HDVLLSNEED RKVGKLFEDT KYTTLIAKLK SDGIPMYKRN VMILTNPVAA KKNVSINTVT YEWAPPVQNQ ALARQYMQML PKEKQPVAGS EGAQYRKKQL AKQLPAHDQD PSKCHELSPR EVKEMEQFVK KYKSEALGVG DVKLPCEMDA QGPKQMNIPG GDRSTPAAVG AMEDKSAEHK RTQYSCYCCK LSMKEGDPAI YAERAGYDKL WHPACFVCST CHELLVDMIY FWKNEKLYCG RHYCDSEKPR CAGCDELIFS NEYTQAENQN WHLKHFCCFD CDSILAGEIY VMVNDKPVCK PCYVKNHAVV CQGCHNAIDP EVQRVTYNNF SWHASTECFL CSCCSKCLIG QKFMPVEGMV FCSVECKKRM S
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.
  • 基因功能参考文献：
    1. validated two new TES cocomplex partners: TGFB1I1 and a short form of the glucocorticoid receptor. TES and TGFB1I1 are shown to oppositely affect cell spreading providing biological validity for their copresence in complexes since they act in similar processes PMID: 28378594
    2. these data indicate that TES functions as a necessary suppressor of colorectal cancer progression by activating p38-MAPK signaling pathways. PMID: 27323777
    3. testin region (amino acids 52-233) harbouring the PET domain interacts with the C-terminal LIM1-2 domains PMID: 28542564
    4. Testin plays an important role in the development and progression of non-small cell lung cancer. Testin is a tumor suppressor. PMID: 28000866
    5. VASP, zyxin and TES are tension-dependent members of focal adherens junctions independent of the alpha-catenin-vinculin module. PMID: 26611125
    6. we confirm that the TES promoter is unmethylated in normal adult and fetal tissues. Re-expression of TESTIN protein in acute lymphoblastic leukemia cells using expression plasmid transfection results in rapid cell death or cell cycle arrest. PMID: 26985820
    7. Loss of TES gene expression is associated with nasopharyngeal carcinoma. PMID: 25824796
    8. findings suggest that the TES gene is a novel tumor suppressor gene PMID: 25498217
    9. TESTIN was hypermethylated in 43.7% endometrial cancer tissues (p < 0.001). Moreover, TESTIN hypermethylation was significantly correlated with advanced tumor stage, deep myometrial invasion and lymphatic node metastasis. PMID: 25720371
    10. Downregulation of TES was associated with breast cancer. PMID: 25119600
    11. TESTIN was commonly downregulated in human endometrial carcinoma and was associated with poor prognostic markers. PMID: 24929083
    12. A further significant correlation was observed between TES downregulation and the luminal B subtype independent of survivin expression. PMID: 23715752
    13. TES, as a valuable marker of breast cancer prognosis, plays an important role in the development and progression of breast cancer. TES may be an effective novel target in breast cancer prevention and treatment. PMID: 22957844
    14. Low TES gene expression is associated with coronary artery disease. PMID: 22156939
    15. Alterations of TES mRNA level may predict the location of metastasis. CAV1 possibly affect the cancer cell invasion PMID: 22201996
    16. These results suggest an interplay between the CaR and testin in the regulation of CaR-mediated Rho signalling with possible effects on the cytoskeleton. PMID: 21843504
    17. data implicate TES methylation in ALL and provide additional evidence for the involvement of LIM domain proteins in leukaemogenesis PMID: 20573277
    18. results support the role of TES as a TSG in gastric carcinogenesis and that TES is inactivated primarily by LOH and CpG island methylation PMID: 20626849
    19. The expression level of TES is significantly down-regulated in primary gastric cancer. PMID: 18799041
    20. TES gene functions as a tumor suppressor gene and is frequently silenced by hypermethylation and loss of heterozygosity in ovarian cancers. PMID: 20180808
    21. TES is best candidate tumor suppressor gene at 7q31 in prostate tumors PMID: 15252854
    22. Loss of TES from focal adhesions results in loss of actin stress fibres. PMID: 15662727
    23. Oservations identify Tes as an atypical binding partner of EVH1 domain of Mena and a regulator specific to a single Ena/VASP family member. PMID: 18158903
    24. Results suggest that testin has different conformational states in different cellular compartments, and a "closed" conformational state of TES may be involved in nucleolar localization. PMID: 18696217
    25. Inactivation of TESTIN is involved in head and neck carcinogenesis through its downregulation. PMID: 19289703

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  • 亚细胞定位：
    Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers.
  • 蛋白家族：
    Prickle / espinas / testin family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 14620

    OMIM: 606085

    KEGG: hsa:26136

    STRING: 9606.ENSP00000350937

    UniGene: Hs.592286