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TCP10L Antibody

  • 货号：
    CSB-PA023322GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8TDR4
  • 基因名：
    TCP10L
  • 别名：
    TCP10L antibody; PRED77 antibody; T-complex protein 10A homolog 1 antibody; T-complex protein 10A-1 antibody; TCP10A-1 antibody; TCP10-like antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human TCP10L
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.
  • 基因功能参考文献：
    1. TCP10L stabilizes MAD1 protein level through direct interaction, and they cooperatively regulate cell cycle progression. PMID: 26698869
    2. Overexpression of TCP10L in hepatocellular carcinoma cells suppressed colony formation, inhibited cell cycle progression through G0/G1 phase, and attenuated cell growth in vivo. PMID: 24565846
    3. The result revealed that TCP10L expressed specifically in the human liver and testis PMID: 14586771
    4. Data suggest that the biological function of the interaction between T-complex protein 10-like and MAD4 may be to maintain the differentiation state in liver cells. PMID: 15469726
    5. The specific expression pattern of TCP10L and interaction with DAPK-3 implies that TCP10L might play crucially important roles in spermatogenesis through its interaction with DAPK-3. PMID: 15910542

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TCP10 family
  • 组织特异性：
    Expressed in liver and testis. Expressed in the seminiferous tubules (at protein level).
  • 数据库链接：

    HGNC: 11657

    OMIM: 608365

    KEGG: hsa:140290

    STRING: 9606.ENSP00000300258

    UniGene: Hs.728804